GNF-PF-835 (CID 4329551) - BioAssay Data Summary for Compound
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BioActivity Outcomes:
Probe(1)
 
 
Active(1)
 
 
Inactive(1)
 
 
Unspecified(7)
 
 
Top Targets:
NR LBD SF-1(1)
 
 
BioAssay Types:
Literature(4)
 
 
 
 
Summary(1)
 
 
BioActivity Types:
EC50(2)
 
 
IC50(2)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 10    Data Row: 10   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID46499828]
 Summary of probe development efforts to identify inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1). [AID1844, Type: summary]steroidogenic factor-1 [Homo sapiens] [gi:216409744]
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2
[SID46499828]
 Summary of probe development efforts to identify inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1). [AID1844, Type: summary]steroidogenic factor-1 [Homo sapiens] [gi:216409744]
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3
[SID46499828]
 Summary of probe development efforts to identify inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1). [AID1844, Type: summary]steroidogenic factor-1 [Homo sapiens] [gi:216409744]
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4
[SID103565112]
IC50 0.2Inhibition of GAL4-tagged NR5A1 by luciferase assay [AID329653, Type: Literature]
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5
[SID103565112]
EC50 1.218NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay [AID449704, Type: other]
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6
[SID103565112]
EC50 1.25NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay [AID449703, Type: other]
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7
[SID103565112]
CC50 10NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) [AID449705, Type: other]
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8
[SID103565112]
 NOVARTIS: Inhibition Frequency Index (IFI) - the number of HTS assays where a compound showed > 50% inhibition/induction, expressed as a percentage of the number of assays in which the compound was tested. [AID449706, Type: other]
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9
[SID103565112]
 Inhibition of GAL4-tagged RORalpha at 100 uM by luciferase assay [AID329656, Type: Literature]
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10
[SID103565112]
 Inhibition of HSV1 GAL4-tagged VP16 at 100 uM by luciferase assay [AID329658, Type: Literature]
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11
[SID103565112]
 NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence. [AID602118, Type: other]
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12
[SID131332494]
IC50 Novartis GNF Liver Stage Dataset: Malariabox Annotation [AID602156, Type: Literature]
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