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Idarubicin (CID 42890) - Compound BioActivity Data
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BioActivity Outcomes:
Active(144)
 
 
Inactive(89)
 
 
Inconclusive(56)
 
 
Unspecified(171)
 
 
Top Targets:
7TM GPCR Srx(22)
 
 
 
 
 
7TM GPCR Srsx(16)
 
 
 
p450(8)
 
 
HELICc(7)
 
 
 
Bromo ALL-1(6)
 
 
BioAssay Types:
Confirmatory(177)
 
 
 
 
Literature(116)
 
 
 
 
 
Screening(11)
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(175)
 
 
 
 
IC50(141)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 370    Data Row: 460   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103311042]
IC50 0.00071Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
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2
[SID103311042]
IC50 0.001Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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3
[SID103311042]
IC50 0.00105Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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4
[SID103311042]
IC50 0.00105Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay [AID524794, Type: Literature]
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5
[SID103311042]
IC50 0.00117Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay [AID524795, Type: Literature]
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6
[SID103311042]
IC50 0.00126Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay [AID524792, Type: Literature]
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7
[SID103311042]
IC50 0.00141Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay [AID524793, Type: Literature]
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8
[SID103311042]
IC50 0.002Cytotoxic activity against K562 erythroleukemic cells [AID95000, Type: Literature]
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9
[SID103311042]
IC50 0.012Cytotoxicity against human K562 cells after 5 days by XTT assay [AID312292, Type: Literature]
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10
[SID50106402]
Potency 0.0398qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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11
[SID50106403]
Potency 0.0398qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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12
[SID50106404]
Potency 0.0398qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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13
[SID50106404]
Potency 0.0999S16 Schwann cell PMP22 intronic element beta-lactamase assay [AID624044, Type: confirmatory]peripheral myelin protein 22 [Rattus norvegicus] [gi:8393992]
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14
[SID90340569]
Potency 0.4108qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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15
[SID90340569]
Potency 0.414High Content Imaging Cell-Based qHTS for Inhibitors of the mTORC1 Signaling Pathway in MEF Cells [AID2667, Type: confirmatory]serine/threonine-protein kinase mTOR [Homo sapiens] [gi:4826730]
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16
[SID50106402]
Potency 0.5623Counterscreen for RECQ1 Inhibitors: ADP Fluorescence Polarization Displacement Assay [AID2711, Type: confirmatory]
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17
[SID50106402]
Potency 0.5623Counterscreen for BLMA Inhibitors: ADP Fluorescence Polarization Displacement Assay [AID2712, Type: confirmatory]
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18
[SID90340569]
Potency 0.5802Validation screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID493106, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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19
[SID50106404]
Potency 0.631qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP) [AID1688, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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20
[SID50106402]
Potency 0.7079qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 3D7 [AID1876, Type: confirmatory]
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21
[SID103311042]
IC50 0.89Displacement of SYBR from phage lambda DNA by FID assay [AID731876, Type: other]
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22
[SID50106402]
Potency 1qHTS for differential inhibitors of proliferation of Plasmodium falciparum line W2 [AID1883, Type: confirmatory]
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23
[SID90340569]
Potency 1.0621qHTS Validation Assay for the Inhibitors of DNA Replication in Gram-Positive Bacteria [AID485295, Type: confirmatory]DNA polymerase III [Bacillus subtilis] [gi:30027657]
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24
[SID50106402]
Potency 1.122qHTS for differential inhibitors of proliferation of Plasmodium falciparum line HB3 [AID1886, Type: confirmatory]
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25
[SID50106402]
Potency 1.122qHTS for differential inhibitors of proliferation of Plasmodium falciparum line GB4 [AID1816, Type: confirmatory]
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26
[SID50106402]
Potency 1.2589qHTS for differential inhibitors of proliferation of Plasmodium falciparum line D10 [AID1877, Type: confirmatory]
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27
[SID50106402]
Potency 1.2589qHTS for differential inhibitors of proliferation of Plasmodium falciparum line Dd2 [AID1882, Type: confirmatory]
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28
[SID50106402]
Potency 1.5849qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 7G8 [AID1815, Type: confirmatory]
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29
[SID103311042]
IC50 1.97Displacement of YOYO1 from phage lambda DNA by FID assay [AID731877, Type: other]
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30
[SID50106404]
Potency 2.0031qHTS Fluorescence Polarization (FP) Assay for Inhibitors of MLL CXXC domain - DNA interaction: Fluorescein FP [AID624160, Type: confirmatory]
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31
[SID103311042]
IC50 2.3Cytotoxicity against mouse DA-3 cells after 24 hrs by XTT assay [AID731883, Type: other]
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32
[SID90340569]
Potency 2.3281High Content Imaging Cell-Based qHTS for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells [AID2666, Type: confirmatory]serine/threonine-protein kinase mTOR [Homo sapiens] [gi:4826730]
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33
[SID50106404]
Potency 2.6855Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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34
[SID50106402]
Potency 2.8184qHTS FP-Based Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2573, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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35
[SID90340569]
Potency 2.9091HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Potentiators [AID488982, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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36
[SID103311042]
IC50 3.2Cytotoxicity against human ES2 cells after 24 hrs by XTT assay [AID731882, Type: other]
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37
[SID50106402]
Potency 3.2944Quantitative high throughput screen for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID488745, Type: confirmatory]
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38
[SID50106402]
Potency 3.5481qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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39
[SID103311042]
IC50 3.61Antimycobacterial activity against Mycobacterium smegmatis grown in Luria-Bertani broth medium assessed as growth inhibition in mid-logarithmic phase by GFP-based fluorescence assay [AID562243, Type: Literature]
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40
[SID103311042]
IC50 3.61Antimycobacterial activity against Mycobacterium smegmatis grown in Luria-Bertani broth medium assessed as growth inhibition in mid-logarithmic phase by spectrophotometry [AID562240, Type: Literature]
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41
[SID50106402]
Potency 3.6964Quantitative high throughput screen for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID488752, Type: confirmatory]
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42
[SID50106404]
Potency 3.7933Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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43
[SID103311042]
IC50 4.5Cytotoxicity against human SKOV3 cells after 24 hrs by XTT assay [AID731884, Type: other]
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44
[SID103311042]
IC50 5.13Antimycobacterial activity against Mycobacterium smegmatis grown in nitrogen -limited broth medium assessed as growth inhibition in mid-logarithmic phase by spectrophotometry [AID562242, Type: Literature]
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45
[SID103311042]
IC50 5.13Antimycobacterial activity against Mycobacterium smegmatis grown in nitrogen -limited broth medium assessed as growth inhibition in mid-logarithmic phase by GFP-based fluorescence assay [AID562245, Type: Literature]
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46
[SID90340569]
Potency 5.8024Validation screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID493107, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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47
[SID103311042]
IC50 6.62HARVARD: Inhibition of liver stage Plasmodium berghei infection in HepG2 cells [AID685501, Type: other]
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48
[SID103311042]
IC50 6.68Antimycobacterial activity against Mycobacterium smegmatis grown in carbon-limited broth medium assessed as growth inhibition in mid-logarithmic phase by spectrophotometry [AID562241, Type: Literature]
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49
[SID103311042]
IC50 6.68Antimycobacterial activity against Mycobacterium smegmatis grown in carbon-limited broth medium assessed as growth inhibition in mid-logarithmic phase by GFP-based fluorescence assay [AID562244, Type: Literature]
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50
[SID103311042]
IC50 7.3Cytotoxicity against human MCF7 cells after 24 hrs by XTT assay [AID731885, Type: other]
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