trimethylenediamine (CID 428) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(1)
 
 
Inactive(1)
 
 
Unspecified(13)
 
 
Top Targets:
PBP1 iGluR NM..(1)
 
 
BioAssay Types:
Literature(14)
 
 
 
SAR
Target summary
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 15    Data Row: 15   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID48415098]
 DSSTox (EPAFHM) EPA Fathead Minnow Acute Toxicity [AID1188, Type: other]
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2
[SID103436106]
 Cytotoxicity against Mycobacterium bovis Bacillus Calmette-Guerin infected mouse J774 macrophage assessed as cell viability at 100 ug/mL after 48 hrs by MTT assay [AID448534, Type: Literature]
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3
[SID103436106]
 Partition coefficient (logP) [AID22299, Type: Literature]
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4
[SID103436106]
 Dissociation constant (pK1) [AID25056, Type: Literature]
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5
[SID103436106]
 Dissociation constant (pK2) [AID25063, Type: Literature]
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6
[SID103436106]
 Enhanced binding of [3H]MK-801 to N-methyl-D-aspartate glutamate receptor in presence of spermine [AID143006, Type: Literature]Glutamate receptor ionotropic, NMDA 2B [gi:548372]
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7
[SID103436106]
 Enhanced binding of [3H]MK-801 to N-methyl-D-aspartate glutamate receptor in presence of spermine [AID143006, Type: Literature]Glutamate receptor ionotropic, NMDA 2B [gi:548372]
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8
[SID103436106]
 Cytotoxicity against mouse J774 macrophage assessed as cell viability at 1 ug/mL after 48 hrs by MTT assay [AID448381, Type: Literature]
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9
[SID103436106]
 Cytotoxicity against mouse J774 macrophage assessed as cell viability at 10 ug/mL after 48 hrs by MTT assay [AID448530, Type: Literature]
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10
[SID103436106]
 Cytotoxicity against mouse J774 macrophage assessed as cell viability at 100 ug/mL after 48 hrs by MTT assay [AID448531, Type: Literature]
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11
[SID103436106]
 Cytotoxicity against Mycobacterium bovis Bacillus Calmette-Guerin infected mouse J774 macrophage assessed as cell viability at 1 ug/mL after 48 hrs by MTT assay [AID448532, Type: Literature]
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12
[SID103436106]
 Cytotoxicity against Mycobacterium bovis Bacillus Calmette-Guerin infected mouse J774 macrophage assessed as cell viability at 10 ug/mL after 48 hrs by MTT assay [AID448533, Type: Literature]
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13
[SID103436106]
 Calculated partition coefficient (clogP) [AID15721, Type: Literature]
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14
[SID103436106]
 Percentage of the diamine which is monoprotonated at pH 7.4 [AID15290, Type: Literature]
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15
[SID103436106]
 Percent [3H]MK-801 bound to N-methyl-D-aspartate glutamate receptor in the presence of 20 uM spermine assuming 100% in the absence of added diamine. [AID143007, Type: Literature]
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16
[SID103436106]
 Antimicrobial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 assessed as minimum inhibitory concentration after 24 hrs by micro plate Alamar blue assay [AID448380, Type: Literature]
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