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MLS002630909 (CID 42628039) - Compound BioActivity Data
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BioActivity Outcomes:
Active(7)
 
 
Inactive(342)
 
 
Inconclusive(16)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(14)
 
 
7TM GPCR Srsx(12)
 
 
Troponin(4)
 
 
RasGEF(4)
 
 
CAP ED(4)
 
 
BioAssay Types:
Screening(251)
 
 
 
Confirmatory(100)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(86)
 
 
 
 
 
EC50(8)
 
 
 
IC50(5)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 327    Data Row: 366   Total Pages: 19   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID81065445]
EC50_MICROM 3.357Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype protein [AID2019, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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2
[SID87349028]
Potency 3.6626A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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3
[SID87349028]
Potency 11.2202qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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4
[SID87349028]
Potency 12.5893qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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5
[SID87349028]
Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis: Fluroescence-based biochemical high throughput Glycerophosphate Dehydrogenase-Triosephosphate Isomerase (GDH-TPI) assay to identify assay artifacts [AID652141, Type: screening]
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6
[SID87349028]
Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID588726, Type: screening]fructose-bisphosphate aldolase [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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7
[SID87349028]
Fluorescence-based biochemical high throughput confirmation assay for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID651616, Type: screening]fructose-bisphosphate aldolase [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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8
[SID87349028]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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9
[SID81065445]
EC50_MICROM 0.449Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac1 activated mutant [AID2048, Type: confirmatory]Rac1 protein [Homo sapiens] [gi:8574038]
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10
[SID87349028]
Potency 2.8184HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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11
[SID81065445]
EC50_MICROM 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac1 wildtype [AID2055, Type: confirmatory]Rac1 protein [Homo sapiens] [gi:8574038]
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12
[SID81065445]
EC50_MICROM 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype [AID2041, Type: confirmatory]GTP-binding protein (rab7) [Canis lupus familiaris] [gi:164058]
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13
[SID81065445]
EC50_MICROM 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype [AID2047, Type: confirmatory]ras protein, partial [Homo sapiens] [gi:190938]
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14
[SID81065445]
EC50_MICROM 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras activated mutant [AID2050, Type: confirmatory]ras protein, partial [Homo sapiens] [gi:190938]
View
15
[SID81065445]
EC50_MICROM 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype [AID2045, Type: confirmatory]Ras-related protein Rab-2A [gi:46577642]
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16
[SID81065445]
EC50_MICROM 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant [AID2020, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
View
17
[SID87349028]
Potency 79.4328qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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18
[SID87349028]
Identification of VIF Inhibitors Measured in Cell-Based System Using Imaging - 2108-01_Inhibitor_SinglePoint_HTS_Activity [AID602346, Type: screening]Vif [Human immunodeficiency virus 1] [gi:9629361]
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19
[SID87349028]
TRFRET-based biochemical primary high throughput screening assay to identify small molecules that bind to the HIV-1-gp120 binding antibody, PG9 [AID624416, Type: screening]Envelope surface glycoprotein gp160, precursor [Human immunodeficiency virus 1] [gi:9629363]
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20
[SID87349028]
Flow Cytometric HTS Screen for inhibitors of the ABC transporter ABCB6 for MLPCN Compound Set [AID602162, Type: screening]ATP-binding cassette sub-family B member 6, mitochondrial [Homo sapiens] [gi:9955963]
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