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MLS002630903 (CID 42608819) - Compound BioActivity Data
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BioActivity Outcomes:
Active(6)
 
 
Inactive(349)
 
 
Inconclusive(10)
 
 
Unspecified(1)
 
 
Top Targets:
7tm 4(26)
 
 
Troponin(4)
 
 
alkPPc(4)
 
 
RasGEF(4)
 
 
ABCC CFTR1(4)
 
 
BioAssay Types:
Screening(250)
 
 
 
Confirmatory(102)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(87)
 
 
 
 
EC50(8)
 
 
 
IC50(5)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 327    Data Row: 366   Total Pages: 19   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID81040323]
EC50_MICROM 2.495Oxadiazole SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac1 wildtype [AID2027, Type: confirmatory]Rac1 protein [Homo sapiens] [gi:8574038]
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2
[SID81040323]
EC50_MICROM 2.673Oxadiazole SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant [AID2009, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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3
[SID81040323]
EC50_MICROM 3.381Oxadiazole SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac1 activated mutant [AID2051, Type: confirmatory]Rac1 protein [Homo sapiens] [gi:8574038]
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4
[SID87349022]
Luminescence-based cell-based primary high throughput screening assay to identify activators of the DAF-12 from the parasite H. contortus (hcDAF-12) [AID652067, Type: screening]Protein DAF-12, isoform a [Caenorhabditis elegans] [gi:71987181]
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5
[SID87349022]
Screen for inhibitors of the SWI/SNF chromatin remodeling complex (esBAF) in mouse embryonic stem cells with Luciferase reporter assay Measured in Cell-Based System Using Plate Reader - 2141-01_Inhibitor_SinglePoint_HTS_Activity [AID602393, Type: screening]transcription activator BRG1 isoform 1 [Mus musculus] [gi:291463269]
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6
[SID87349022]
AbsAC40_uM Screen for inhibitors of the SWI/SNF chromatin remodeling complex (esBAF) in mouse embryonic stem cells with Luciferase reporter assay Measured in Cell-Based System Using Plate Reader - 2141-01_Inhibitor_Dose_CherryPick_Activity [AID651717, Type: confirmatory]
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7
[SID87349022]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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8
[SID81040323]
EC50_MICROM 0.708Oxadiazole SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype [AID2031, Type: confirmatory]GTP-binding protein (rab7) [Canis lupus familiaris] [gi:164058]
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9
[SID81040323]
EC50_MICROM 30Oxadiazole SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras activated mutant [AID2042, Type: confirmatory]ras protein, partial [Homo sapiens] [gi:190938]
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10
[SID81040323]
EC50_MICROM 30Oxadiazole SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype [AID2053, Type: confirmatory]ras protein, partial [Homo sapiens] [gi:190938]
View
11
[SID81040323]
EC50_MICROM 30Oxadiazole SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype [AID2033, Type: confirmatory]Ras-related protein Rab-2A [gi:46577642]
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12
[SID81040323]
EC50_MICROM 30Oxadiazole SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype [AID2037, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
View
13
[SID87349022]
HTS Assay for Inhibitors of Akt Phophorylation: Primary Screen [AID651550, Type: screening]RAC-alpha serine/threonine-protein kinase [gi:60391226]
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14
[SID87349022]
Potency qHTS of Trypanosoma Brucei Inhibitors [AID624173, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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15
[SID87349022]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1, non-receptor tyrosine kinase (Abl) [AID588664, Type: screening]tyrosine-protein kinase ABL1 isoform a [Homo sapiens] [gi:62362414]
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16
[SID87349022]
Fluorescence Polarization with CAL-PDZ Measured in Biochemical System Using Plate Reader - 2109-02_Inhibitor_SinglePoint_HTS_Activity [AID602252, Type: screening]Golgi-associated PDZ and coiled-coil motif-containing protein isoform b [Homo sapiens] [gi:62868213]
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17
[SID87349022]
Potency Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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18
[SID87349022]
Luminescence-based cell-based primary high throughput screening assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504326, Type: screening]delta-type opioid receptor [Homo sapiens] [gi:63477962]
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19
[SID87349022]
Luminescence-based cell-based primary high throughput screening assay to identify inverse agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504357, Type: screening]delta-type opioid receptor [Homo sapiens] [gi:63477962]
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20
[SID87349022]
Rtt109/Vps75 Measured in Biochemical System Using Plate Reader - 2106-01_Inhibitor_SinglePoint_HTS_Activity [AID540336, Type: screening]hypothetical protein CaO19.7491 [Candida albicans SC5314] [gi:68474550]
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