MLS002206612 (CID 42601260) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(27)
 
 
Inactive(333)
 
 
Inconclusive(16)
 
 
Unspecified(5)
 
 
Top Targets:
7TM GPCR Srx(14)
 
 
ABCC CFTR1(9)
 
 
 
 
7TM GPCR Srsx(6)
 
 
Peptidase C48(4)
 
 
alkPPc(4)
 
 
BioAssay Types:
Screening(258)
 
 
 
Confirmatory(113)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(79)
 
 
 
 
 
IC50(17)
 
 
 
 
EC50(5)
 
 
AC50(4)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 375    Data Row: 381   Total Pages: 8   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID74373943]
Potency 0.8275Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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2
[SID74373943]
Potency 1.0418Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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3
[SID74373943]
IC50 4.14Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344, Type: confirmatory]CFTR gene product [Homo sapiens] [gi:90421313]
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4
[SID74373943]
IC50 4.14Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344, Type: confirmatory]CFTR gene product [Homo sapiens] [gi:90421313]
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5
[SID74373943]
AC50 7.34Inhibitors of Epstein-Barr LMP1 inducible NF-kappaB luciferase reporter Measured in Cell-Based System Using Plate Reader - 2122-01_Inhibitor_Dose_CherryPick_Activity [AID588343, Type: confirmatory]
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6
[SID131404686]
AbsAC35_uM 7.88Inhibitors of Epstein-Barr LMP1 inducible NF-kappaB luciferase reporter Measured in Cell-Based System Using Plate Reader - 2122-05_Inhibitor_Dose_DryPowder_Activity [AID624359, Type: confirmatory]
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7
[SID74373943]
IC50 8Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a PAF-induced IL8 counterscreen [AID624343, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
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8
[SID74373943]
IC50 8Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a PAF-induced IL8 counterscreen [AID624343, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
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9
[SID74373943]
IC50 8Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a PAF-induced IL8 counterscreen [AID624343, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
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10
[SID131404686]
AbsAC35_uM 8.17Inhibitors of Epstein-Barr LMP1 inducible NF-kappaB luciferase reporter Measured in Cell-Based System Using Plate Reader - 2122-06_Inhibitor_Dose_DryPowder_Activity [AID624360, Type: confirmatory]
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11
[SID74373943]
AC50 16.69Lymphoblastoid Cells (LCL) Cytotoxicity Secondary Assay Measured in Cell-Based System Using Plate Reader - 2122-03_Inhibitor_Dose_CherryPick_Activity_Set2 [AID504882, Type: confirmatory]LMP1 [Human herpesvirus 4] [gi:23893668]
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12
[SID74373943]
Potency 20.5878qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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13
[SID74373943]
IC50 24.3Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a TNFa-induced IL8 counterscreen [AID624347, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
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14
[SID74373943]
IC50 24.3Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a TNFa-induced IL8 counterscreen [AID624347, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
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15
[SID74373943]
IC50 24.3Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a TNFa-induced IL8 counterscreen [AID624347, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
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16
[SID74373943]
Potency 25.929qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]
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17
[SID74373943]
AC50 26.437Viability counterscreen of potential LMP-1 inhibitors in HEK293 cell background Measured in Cell-Based System Using Plate Reader - 2122-02_Inhibitor_Dose_CherryPick_Activity [AID504861, Type: confirmatory]LMP1 [Human herpesvirus 4] [gi:23893668]
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18
[SID74373943]
 Single concentration confirmation of small molecule inhibitors of tim10 yeast via a luminescent assay [AID463215, Type: screening]TPA: Tim10p [Saccharomyces cerevisiae S288c] [gi:285809906]
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19
[SID74373943]
 Inhibitors of Epstein-Barr LMP1 inducible NF-kappaB luciferase reporter Measured in Cell-Based System Using Plate Reader - 2122-01_Inhibitor_SinglePoint_HTS_Activity [AID504558, Type: screening]LMP1 [Human herpesvirus 4] [gi:23893668]
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20
[SID74373943]
 uHTS identification of small molecule inhibitors of tim10 yeast via a luminescent assay [AID463195, Type: screening]TPA: Tim10p [Saccharomyces cerevisiae S288c] [gi:285809906]
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21
[SID74373943]
 HTS Assay for Peg3 Promoter Inhibitors [AID588405, Type: screening]Ppp1r15a gene product [Rattus norvegicus] [gi:78486550]
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22
[SID74373943]
 uHTS identification of small molecule inhibitors of tim23-1 yeast via a luminescent assay [AID463212, Type: screening]TPA: Tim23p [Saccharomyces cerevisiae S288c] [gi:285814664]
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23
[SID74373943]
 Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Full-Length Luciferase Counterscreen assay [AID504607, Type: screening]
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24
[SID74373943]
 Luminescence Microorganism Primary HTS to Identify Inhibitors of the SUMOylation Pathway Using a Temperature Sensitive Growth Reversal Mutant Mot1-301 [AID2716, Type: screening]
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25
[SID74373943]
 Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ LAP4_MLPCN. [AID2023, Type: screening]LAP4 [Saccharomyces cerevisiae] [gi:486173]
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26
[SID74373943]
 Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]Breast cancer type 1 susceptibility protein [gi:728984]
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27
[SID74373943]
 Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]Breast cancer type 1 susceptibility protein [gi:728984]
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28
[SID74373943]
 Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 Second Cherry Pick Compounds [AID2621, Type: screening]LAP4 [Saccharomyces cerevisiae] [gi:486173]
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29
[SID74373943]
 uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay [AID588850, Type: screening]CFTR gene product [Homo sapiens] [gi:90421313]
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30
[SID74373943]
 uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay [AID588850, Type: screening]CFTR gene product [Homo sapiens] [gi:90421313]
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31
[SID74373943]
 Single concentration confirmation of uHTS hits for cystic fibrosis induced NFkb Inhibitors in a fluoresence assay [AID602472, Type: screening]CFTR gene product [Homo sapiens] [gi:90421313]
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32
[SID74373943]
 Single concentration confirmation of uHTS hits for cystic fibrosis induced NFkb Inhibitors in a fluoresence assay [AID602472, Type: screening]CFTR gene product [Homo sapiens] [gi:90421313]
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33
[SID74373943]
IC50 Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_1, Type: confirmatory]CFTR gene product [Homo sapiens] [gi:90421313]
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34
[SID74373943]
IC50 Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_1, Type: confirmatory]CFTR gene product [Homo sapiens] [gi:90421313]
View
35
[SID74373943]
 uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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36
[SID74373943]
 uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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37
[SID74373943]
 Single concentration confirmation of uHTS for Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID489028, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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38
[SID74373943]
 Single concentration confirmation of uHTS for Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID489028, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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39
[SID74373943]
IC50 Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_2, Type: confirmatory]CFTR gene product [Homo sapiens] [gi:90421313]
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40
[SID74373943]
IC50 Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_2, Type: confirmatory]CFTR gene product [Homo sapiens] [gi:90421313]
View
41
[SID74373943]
IC50 Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_3, Type: confirmatory]CFTR gene product [Homo sapiens] [gi:90421313]
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42
[SID74373943]
IC50 Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_3, Type: confirmatory]CFTR gene product [Homo sapiens] [gi:90421313]
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43
[SID74373943]
IC50 Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_5, Type: confirmatory]CFTR gene product [Homo sapiens] [gi:90421313]
View
44
[SID74373943]
IC50 Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_5, Type: confirmatory]CFTR gene product [Homo sapiens] [gi:90421313]
View
45
[SID74373943]
IC50 Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_6, Type: confirmatory]CFTR gene product [Homo sapiens] [gi:90421313]
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46
[SID74373943]
IC50 Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_6, Type: confirmatory]CFTR gene product [Homo sapiens] [gi:90421313]
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47
[SID74373943]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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48
[SID74373943]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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49
[SID74373943]
Potency 3.1623qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
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50
[SID74373943]
Potency 50.1187qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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