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Mitoxantrone (CID 4212) - Compound BioActivity Data
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BioActivity Outcomes:
Active(506)
 
 
Inactive(461)
 
 
Inconclusive(104)
 
 
Unspecified(622)
 
 
Top Targets:
7TM GPCR Srx(35)
 
 
 
 
 
7TM GPCR Srsx(27)
 
 
 
 
p450(22)
 
 
 
 
 
ABCG EPDR(15)
 
 
ABC MTABC3 MD..(12)
 
 
BioAssay Types:
Literature(637)
 
 
 
 
 
Confirmatory(544)
 
 
 
 
 
Screening(239)
 
 
 
 
 
BioActivity Types:
IC50(336)
 
 
 
 
 
Potency(291)
 
 
 
 
 
EC50(15)
 
 
 
 
AC50(12)
 
 
 
Ki(2)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1487    Data Row: 1693   Total Pages: 85   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103167833]
IC50 4e-05Cytotoxic potency required to inhibit L1210 cell growth by 50% after cell drug contact for 48 hrs [AID98563, Type: Literature]
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2
[SID103167833]
GI50 0.00033Cytotoxicity against human HL60 cells after 48 hrs by MTT assay [AID320437, Type: Literature]
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3
[SID103167833]
IC50 0.00035Antiproliferative activity against MDA435/LCC6 cells by ELISA [AID272492, Type: Literature]
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4
[SID103167833]
IC50 0.00055Concentration required to inhibit A2780-cell growth by 50% [AID10003, Type: Literature]
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5
[SID103167833]
IC50 0.00055Cytotoxic potency required to inhibit A2780 cell growth by 50% after cell drug contact for 96 hrs [AID10007, Type: Literature]
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6
[SID103167833]
IC50 0.00059Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
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7
[SID103167833]
IC50 0.00065Cytotoxic potency required to inhibit G-361 cell growth by 50% [AID72412, Type: Literature]
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8
[SID103167833]
IC50 0.00075Cytotoxicity against human H460M cancer cell line was determined after 144 hr [AID248039, Type: Literature]
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9
[SID103167833]
IC50 0.00081Compound was tested in vitro for cytotoxicity against HL60 human leukemia cell line (72 hr exposure to compound) [AID81308, Type: Literature]
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10
[SID103167833]
IC50 0.00083Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay [AID524795, Type: Literature]
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11
[SID103167833]
IC50 0.00085Cytotoxicity against human H460M cancer cell line was determined after 1 hr [AID253343, Type: Literature]
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12
[SID103167833]
IC50 0.00093Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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13
[SID103167833]
IC50 0.001Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay [AID524793, Type: Literature]
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14
[SID103167833]
IC50 0.001Tested for the cytotoxicity against the repair deficient xrs-6 chinese hamster ovary cell line [AID51931, Type: Literature]
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15
[SID103167833]
IC50 0.00112Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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16
[SID103167833]
IC50 0.00141Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay [AID524794, Type: Literature]
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17
[SID103167833]
IC50 0.00148Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay [AID524792, Type: Literature]
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18
[SID103167833]
IC50 0.0016Tested in vitro against murine L1210 leukemia. [AID98403, Type: Literature]
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19
[SID103167833]
IC50 0.0016In vitro for its inhibitory activity against murine L1210 leukemia [AID132862, Type: Literature]
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20
[SID103167833]
IC50 0.002In vitro extracellular concentration required to reduce cell population to 50% against L1210 leukemia cells [AID101065, Type: Literature]
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