Mitoxantrone (CID 4212) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(447)
 
 
Inactive(370)
 
 
Inconclusive(96)
 
 
Unspecified(403)
 
 
Top Targets:
7TM GPCR Srx(27)
 
 
 
 
 
p450(23)
 
 
 
 
 
7TM GPCR Srsx(16)
 
 
 
ABCG EPDR(12)
 
 
ABC MTABC3 MD..(12)
 
 
BioAssay Types:
Literature(545)
 
 
 
 
 
Confirmatory(364)
 
 
 
 
 
Screening(185)
 
 
 
 
 
BioActivity Types:
IC50(317)
 
 
 
 
 
Potency(238)
 
 
 
 
 
AC50(7)
 
 
 
EC50(6)
 
 
 
Ki(2)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1164    Data Row: 1316   Total Pages: 27   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103167833]
IC50 4e-05Cytotoxic potency required to inhibit L1210 cell growth by 50% after cell drug contact for 48 hrs [AID98563, Type: Literature]
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2
[SID103167833]
GI50 0.00033Cytotoxicity against human HL60 cells after 48 hrs by MTT assay [AID320437, Type: Literature]
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3
[SID103167833]
IC50 0.00035Antiproliferative activity against MDA435/LCC6 cells by ELISA [AID272492, Type: Literature]
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4
[SID103167833]
IC50 0.00055Concentration required to inhibit A2780-cell growth by 50% [AID10003, Type: Literature]
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5
[SID103167833]
IC50 0.00055Cytotoxic potency required to inhibit A2780 cell growth by 50% after cell drug contact for 96 hrs [AID10007, Type: Literature]
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6
[SID103167833]
IC50 0.00059Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
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7
[SID103167833]
IC50 0.00065Cytotoxic potency required to inhibit G-361 cell growth by 50% [AID72412, Type: Literature]
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8
[SID103167833]
IC50 0.00075Cytotoxicity against human H460M cancer cell line was determined after 144 hr [AID248039, Type: Literature]
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9
[SID103167833]
IC50 0.00081Compound was tested in vitro for cytotoxicity against HL60 human leukemia cell line (72 hr exposure to compound) [AID81308, Type: Literature]
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10
[SID103167833]
IC50 0.00083Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay [AID524795, Type: Literature]
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11
[SID103167833]
IC50 0.00085Cytotoxicity against human H460M cancer cell line was determined after 1 hr [AID253343, Type: Literature]
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12
[SID103167833]
IC50 0.00093Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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13
[SID103167833]
IC50 0.001Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay [AID524793, Type: Literature]
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14
[SID103167833]
IC50 0.001Tested for the cytotoxicity against the repair deficient xrs-6 chinese hamster ovary cell line [AID51931, Type: Literature]
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15
[SID103167833]
IC50 0.00112Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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16
[SID103167833]
IC50 0.00141Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay [AID524794, Type: Literature]
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17
[SID103167833]
IC50 0.00148Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay [AID524792, Type: Literature]
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18
[SID103167833]
IC50 0.0016Tested in vitro against murine L1210 leukemia. [AID98403, Type: Literature]
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19
[SID103167833]
IC50 0.0016In vitro for its inhibitory activity against murine L1210 leukemia [AID132862, Type: Literature]
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20
[SID103167833]
IC50 0.002In vitro extracellular concentration required to reduce cell population to 50% against L1210 leukemia cells [AID101065, Type: Literature]
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21
[SID103167833]
IC50 0.0025Antiproliferative activity against human HL60 cells after 72 hrs by SRB assay [AID683860, Type: Literature]
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22
[SID103167833]
IC50 0.0026Cytotoxicity against human K562 cells after 5 days by XTT assay [AID312292, Type: Literature]
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23
[SID103167833]
IC50 0.00265Cytotoxic potency required to inhibit CH1 cell growth by 50% [AID47499, Type: Literature]
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24
[SID103167833]
IC50 0.00265Concentration required to inhibit CH1-cell growth by 50% [AID47668, Type: Literature]
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25
[SID103167833]
IC50 0.003Antiproliferative activity against MES-SA cells by MTT assay after 72 hrs [AID270854, Type: Literature]
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26
[SID103167833]
IC50 0.003In vitro cytotoxicity against uterine sarcoma MES-SA cells [AID255789, Type: Literature]
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27
[SID103167833]
IC50 0.003Tested for inhibitory activity against human tumor cell line A549 (a non small, drug resistant cell line that does not produce P-glycoprotein) of lung carcinoma using sulforhodamine B assay. [AID221330, Type: Literature]
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28
[SID103167833]
IC50 0.0031Tested against A549 lung carcinoma in the sulforhodamine B assay. [AID8485, Type: Literature]
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29
[SID103167833]
IC50 0.0031Activity against A549 cancer cell line. [AID8690, Type: Literature]
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30
[SID103167833]
IC50 0.0033Cytotoxicity against human LoVo cancer cell line was determined after 144 hr [AID248024, Type: Literature]
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31
[SID103167833]
IC50 0.0043Antiproliferative activity against P388 cells by ELISA [AID272494, Type: Literature]
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32
[SID103167833]
IC50 0.005In vitro inhibition of tumor cell growth in the human mammary tumor MCF-7 system [AID102597, Type: Literature]
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33
[SID103167833]
IC50 0.005Anti-tumor activity against murine L1210 sensitive cell line by using MTT assay [AID98203, Type: Literature]
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34
[SID103167833]
IC50 0.0053Cytotoxic potency required to inhibit SKOV-3 cell growth 50% [AID202961, Type: Literature]
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35
[SID103167833]
IC50 0.0053Compound was evaluated for cytotoxicity against SCOV-3 cell lines. [AID200757, Type: other]
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36
[SID103167833]
IC50 0.0053Concentration required to inhibit SKOV-3-cell growth by 50% [AID202844, Type: Literature]
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37
[SID103167833]
IC50 0.0056In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line DU145 [AID55805, Type: Literature]
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38
[SID103167833]
IC50 0.0058Anti-tumor activity against human OVCAR-3 ovarian cancer cell lines by using MTT assay [AID145432, Type: Literature]
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39
[SID103167833]
IC50 0.0058Antitumor activity against human ovarian OVCAR-3 cell lines. [AID145436, Type: Literature]
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40
[SID103167833]
IC50 0.0058Inhibitory activity against OVCAR-3 cell line [AID145445, Type: Literature]
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41
[SID103167833]
IC50 0.0058Cytotoxicity against human HCT116 cancer cell line was determined after 144 hr [AID248060, Type: Literature]
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42
[SID103167833]
IC50 0.006Tested for inhibitory activity against human tumor cell line OVCAR-3, a resistant ovarian carcinoma using sulforhodamine B assay. [AID223628, Type: Literature]
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43
[SID103167833]
IC50 0.00611In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line A2780 [AID10019, Type: Literature]
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44
[SID103167833]
IC50 0.0068Cytotoxicity against human MKN45 cancer cell line was determined after 1 hr [AID253344, Type: Literature]
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45
[SID103167833]
IC50 0.007Cytotoxicity against human PC3 cancer cell line was determined after 144 hr [AID248010, Type: Literature]
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46
[SID103167833]
ID50 0.007In vitro inhibitory activity against L1210 leukemia cell line [AID130603, Type: Literature]
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47
[SID103167833]
LD50 0.007In vitro cytotoxicity against L1210 leukemia cell line [AID134572, Type: Literature]
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48
[SID103167833]
IC50 0.00706Compound was tested in vitro for cytotoxicity against MDR cell line K562R (72 hr exposure to compound) [AID95160, Type: Literature]
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49
[SID103167833]
IC50 0.0071In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line PC3 [AID156652, Type: Literature]
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50
[SID103167833]
IC50 0.008Tested for inhibitory activity against a sensitive strain of human colon carcinoma WiDr using sulforhodamine B assay (it is MRP positive but non-P-glycoprotein). [AID216435, Type: Literature]
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