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AK-968/11369213 (CID 4183496) - Compound BioActivity Data
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BioActivity Outcomes:
Active(43)
 
 
Inactive(332)
 
 
Inconclusive(13)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(14)
 
 
 
7TM GPCR Srsx(9)
 
 
 
CD36(8)
 
 
 
CAP ED(5)
 
 
TRP 2(5)
 
 
BioAssay Types:
Screening(281)
 
 
 
 
Confirmatory(94)
 
 
 
 
 
Literature(9)
 
 
BioActivity Types:
Potency(70)
 
 
 
 
 
AC50(10)
 
 
 
IC50(10)
 
 
EC50(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 347    Data Row: 389   Total Pages: 20   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID47194389]
Potency 1.122qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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2
[SID115950075]
AC50_uM 1.965HTS using DiI-HDL to assay lipid transfer in ldlA[SR-BI] cells Measured in Cell-Based System Using Plate Reader - 2085-01_Inhibitor_Dose_DryPowder_Activity [AID540354, Type: confirmatory]
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3
[SID47194389]
AC50_uM 3.73Luminescence Cell-Based Counter Screen to Identify Inhibitors of Cytokine Induced Apoptosis [AID463206, Type: confirmatory]
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4
[SID47194389]
Potency 3.9811qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode) [AID624417, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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5
[SID115950075]
AC50_uM 5.11HDL Orthogonal Assay: Alexa 488-HDL Measured in Cell-Based System Using Plate Reader - 2085-03_Inhibitor_Dose_DryPowder_Activity [AID588777, Type: confirmatory]scavenger receptor class B member 1 isoform 1 [Mus musculus] [gi:14389423]
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6
[SID47194389]
AC50_uM 6.403Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
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7
[SID47194389]
Potency 6.5131A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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8
[SID47194389]
Potency 7.3078qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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9
[SID47194389]
EC50 8.345Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of of 5'UTR Stem-Loop Driven Alpha-Synuclein mRNA Translation in H4 Neuroglioblastoma Cells [AID1988, Type: confirmatory]
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10
[SID47194389]
Potency 8.9125qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase-type plasminogen activator precursor [Mus musculus] [gi:6679377]
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11
[SID47194389]
Potency 8.9125qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase plasminogen activator surface receptor precursor [Mus musculus] [gi:7242179]
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12
[SID47194389]
Potency 8.9125qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]plasminogen precursor [Mus musculus] [gi:257471003]
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13
[SID47194389]
Potency 9.2qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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14
[SID47194389]
Potency 11.5821qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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15
[SID47194389]
AC50_uM 14.78ATP-based Luminescence in the Absence of Cytokines Measured in Cell-Based System Using Plate Reader - 2061-06_Inhibitor_Dose_CherryPick [AID463229, Type: confirmatory]
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16
[SID47194389]
EC50 15.324Luminescence Cell-Based Dose Response HTS to Identify Inhibitors of Luciferase Translation or Activity in H4 Neuroglioblastoma Cells [AID1990, Type: confirmatory]
View
17
[SID47194389]
AC50_uM 20.209HTS using DiI-HDL to assay lipid transfer in ldlA[SR-BI] cells Measured in Cell-Based System Using Plate Reader - 2085-01_Inhibitor_Dose_CherryPick_Activity [AID493194, Type: confirmatory]scavenger receptor class B member 1 isoform 1 [Mus musculus] [gi:14389423]
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18
[SID47194389]
Potency 20.5962qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation [AID540263, Type: confirmatory]importin subunit beta-1 isoform 1 [Homo sapiens] [gi:19923142]
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19
[SID47194389]
Potency 20.5962qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation [AID540263, Type: confirmatory]snurportin-1 [Homo sapiens] [gi:5031833]
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20
[SID115950075]
AC50_uM 21.87HDL Counter Assay: 3/24 Cytotox Measured in Cell-Based System Using Plate Reader - 2085-02_Inhibitor_Dose_DryPowder_Activity_Set5 [AID602126, Type: confirmatory]
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