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nitazoxanide (CID 41684) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(278)
 
 
Inactive(598)
 
 
Inconclusive(175)
 
 
Unspecified(192)
 
 
Top Targets:
NR LBD PPAR(27)
 
 
 
NR LBD ER(16)
 
 
 
 
NR LBD AR(16)
 
 
 
 
NR LBD TR(12)
 
 
 
 
Bcl-2 like(11)
 
 
BioAssay Types:
Confirmatory(477)
 
 
 
 
Literature(329)
 
 
 
 
 
Screening(200)
 
 
 
 
Summary(48)
 
 
 
 
BioActivity Types:
Potency(366)
 
 
 
 
IC50(47)
 
 
 
 
EC50(17)
 
 
 
Ki(5)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 868    Data Row: 1243   Total Pages: 25   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103479736]
IC50 0.068Antiprotozoan activity against Trichomonas vaginalis GT3 trophozoites after 48 hrs [AID598282, Type: Literature]
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2
[SID103479736]
EC50 0.12Antiviral activity against Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as decrease in extracellular viral DNA measured 24 hrs after last dose [AID606883, Type: Literature]
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3
[SID103479736]
EC50 0.13Antiviral activity against HCV genotype 1a in replicon system [AID533311, Type: Literature]
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4
[SID103479736]
EC50 0.16Antiviral activity against HCV genotype 1b in RP7 replicon cell after 4 days by blot hybridization analysis [AID533313, Type: Literature]
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5
[SID103479736]
EC50 0.21Antiviral activity against HCV genotype 1b infected in Ava5 cells assessed as inhibition of viral replication after 3 days by blot hybridization analysis [AID642456, Type: Literature]
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6
[SID103479736]
Ki 0.3Inhibition of Giardia lamblia recombinant nitroreductase 1 (EAA43030.1) expressed in Escherichia coli [AID325504, Type: Literature]
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7
[SID103479736]
EC50 0.33Antiviral activity against HCV genotype 1a infected in Huh7.5 cells assessed as inhibition of viral replication after 3 days by blot hybridization analysis [AID642459, Type: Literature]
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8
[SID144208424]
Potency-Replicate_1 0.3507qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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9
[SID26719875]
Potency 0.5012qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]Niemann-Pick C1 protein precursor [Homo sapiens] [gi:255652944]
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10
[SID103479736]
IC50 0.504Antiprotozoan activity against Entamoeba histolytica HM1-IMSS trophozoites after 48 hrs [AID598283, Type: Literature]
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11
[SID144208424]
Ratio Potency (uM) 0.555791qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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12
[SID144208424]
Potency-Replicate_1 0.5558qHTS assay for small molecule disruptors of the mitochondrial membrane potential - cell viability [AID720634, Type: confirmatory]
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13
[SID103479736]
EC50 0.59Antiviral activity against Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as decrease in intracellular viral DNA measured 24 hrs after last dose [AID606884, Type: Literature]
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14
[SID144204569]
Potency-Replicate_1 0.6682qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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15
[SID17388853]
Potency 0.7079qHTS assay for environmental chemicals that activate the Aryl hydrocarbon Receptor (AhR) signaling pathway [AID651777, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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16
[SID17388853]
Potency 0.7208Biochemical firefly luciferase enzyme assay for NPC [AID624030, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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17
[SID103479736]
MIC 0.8Antimicrobial activity against Campylobacter jejuni [AID484859, Type: Literature]
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18
[SID144204569]
ATAD5 Potency (uM) 1.18832qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5: Summary [AID720516, Type: summary]ATPase family AAA domain-containing protein 5 [gi:296439460]
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19
[SID103479736]
EC50 1.2Antiviral activity against HCV genotype 1b in NTZ-11 replicon cell after 4 days by blot hybridization analysis [AID533314, Type: Literature]
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20
[SID103479736]
IC50 1.214Antiprotozoan activity against Giardia intestinalis IMSS:0696:1 trophozoites after 48 hrs [AID598281, Type: Literature]
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21
[SID17388853]
Potency 1.2589qHTS Assay for Anthrax Lethal Toxin Internalization [AID912, Type: confirmatory]lethal factor [Bacillus anthracis str. A2012] [gi:21392848]
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22
[SID144204569]
Potency-Replicate_1 1.3333qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 [AID651632, Type: confirmatory]ATPase family AAA domain-containing protein 5 [gi:296439460]
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23
[SID144204569]
Potency-Replicate_1 1.496qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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24
[SID103479736]
EC50 1.5Antiviral activity against HCV genotype 1b in TIZ-9 replicon cell after 4 days by blot hybridization analysis [AID533315, Type: Literature]
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25
[SID144208424]
Potency-Replicate_1 1.5807qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway - cell viability counter screen [AID743194, Type: confirmatory]
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26
[SID144204569]
Ratio Potency (uM) 1.95704qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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27
[SID144208424]
Potency-Replicate_1 1.972qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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28
[SID103479736]
Ki 2.2Inhibition of PFOR Trichomonas vaginalis [AID283185, Type: Literature]
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29
[SID26719875]
Potency 3.1623qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction [AID1461, Type: confirmatory]neuropeptide S receptor isoform A [Homo sapiens] [gi:46395496]
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30
[SID103479736]
IC50 3.25Antiparasitic activity against Cryptosporidium parvum in HCT8 cells [AID260527, Type: Literature]
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31
[SID144208424]
Potency-Replicate_1 3.5387qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway - cell viability counter screen [AID720693, Type: confirmatory]
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32
[SID103479736]
IC50 3.8Antimicrobial activity against Cryptosporidium parvum infected in human HCT-8 cells [AID572366, Type: Literature]
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33
[SID103479736]
IC50 3.89Antimalarial activity against Plasmodium berghei schizonts isolated from parasitized erythrocytes infected Wistar rat measured 16 hrs post compound exposure [AID598286, Type: Literature]
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34
[SID103479736]
Ki 4.5Inhibition of PFOR Helicobacter pylori [AID283187, Type: Literature]
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35
[SID170465090]
Potency-Replicate_1 5.3076qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway - cell viability counter screen [AID743194, Type: confirmatory]
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36
[SID170465090]
Potency-Replicate_1 5.9553qHTS assay for small molecule activators of the heat shock response signaling pathway - cell viability counter screen [AID743209, Type: confirmatory]
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37
[SID17388853]
Potency-Replicate_1 5.9557qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway - cell viability counter screen [AID720652, Type: confirmatory]
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38
[SID144204569]
Potency-Replicate_1 5.9557qHTS assay for small molecule agonists of the p53 signaling pathway [AID651631, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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39
[SID103479736]
IC50 6.18Antileishmanial activity against Leishmania mexicana MHOM/MX/ISETGS promastigotes after 72 hrs by neubauer chamber [AID598284, Type: Literature]
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40
[SID17388853]
Potency 6.6824qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 5 hr assay [AID651755, Type: confirmatory]
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41
[SID144204569]
Potency-Replicate_1 6.74qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway - cell viability counter screen [AID720693, Type: confirmatory]
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42
[SID26719875]
Potency 6.7456qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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43
[SID144208424]
Potency-Replicate_1 7.0606qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway - cell viability counter screen [AID743033, Type: confirmatory]
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44
[SID17388853]
Potency 7.4978qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 1 hr assay [AID651754, Type: confirmatory]
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45
[SID144204569]
Potency-Replicate_1 7.5624qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway - cell viability counter screen [AID743074, Type: confirmatory]
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46
[SID144208424]
Potency-Replicate_1 7.8508qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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47
[SID144204569]
Potency 7.9433qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID720533, Type: confirmatory]
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48
[SID17388853]
Potency 7.9433qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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49
[SID170465090]
Potency-Replicate_1 9.4384qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743211, Type: confirmatory]
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50
[SID144204569]
Potency-Replicate_1 9.4392qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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