nitazoxanide (CID 41684) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(228)
 
 
Inactive(508)
 
 
Inconclusive(86)
 
 
Unspecified(188)
 
 
Top Targets:
NR LBD PPAR(11)
 
 
 
7TM GPCR Srx(10)
 
 
 
Bcl-2 like(10)
 
 
alkPPc(6)
 
 
NR LBD TR(6)
 
 
 
BioAssay Types:
Confirmatory(329)
 
 
 
 
Literature(319)
 
 
 
 
 
Screening(181)
 
 
 
 
BioActivity Types:
Potency(188)
 
 
 
 
IC50(43)
 
 
 
 
EC50(17)
 
 
 
Ki(5)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 754    Data Row: 1010   Total Pages: 21   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103479736]
IC50 0.068Antiprotozoan activity against Trichomonas vaginalis GT3 trophozoites after 48 hrs [AID598282, Type: Literature]
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2
[SID103479736]
EC50 0.12Antiviral activity against Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as decrease in extracellular viral DNA measured 24 hrs after last dose [AID606883, Type: Literature]
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3
[SID103479736]
EC50 0.13Antiviral activity against HCV genotype 1a in replicon system [AID533311, Type: Literature]
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4
[SID103479736]
EC50 0.16Antiviral activity against HCV genotype 1b in RP7 replicon cell after 4 days by blot hybridization analysis [AID533313, Type: Literature]
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5
[SID103479736]
EC50 0.21Antiviral activity against HCV genotype 1b infected in Ava5 cells assessed as inhibition of viral replication after 3 days by blot hybridization analysis [AID642456, Type: Literature]
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6
[SID103479736]
Ki 0.3Inhibition of Giardia lamblia recombinant nitroreductase 1 (EAA43030.1) expressed in Escherichia coli [AID325504, Type: Literature]
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7
[SID103479736]
EC50 0.33Antiviral activity against HCV genotype 1a infected in Huh7.5 cells assessed as inhibition of viral replication after 3 days by blot hybridization analysis [AID642459, Type: Literature]
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8
[SID26719875]
Potency 0.5012qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]NPC1 gene product [Homo sapiens] [gi:255652944]
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9
[SID103479736]
IC50 0.504Antiprotozoan activity against Entamoeba histolytica HM1-IMSS trophozoites after 48 hrs [AID598283, Type: Literature]
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10
[SID103479736]
EC50 0.59Antiviral activity against Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as decrease in intracellular viral DNA measured 24 hrs after last dose [AID606884, Type: Literature]
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11
[SID17388853]
Potency 0.7079qHTS assay for environmental chemicals that activate the Aryl hydrocarbon Receptor (AhR) signaling pathway [AID651777, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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12
[SID17388853]
Potency 0.7079qHTS assay for environmental chemicals that activate the Aryl hydrocarbon Receptor (AhR) signaling pathway [AID651777, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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13
[SID17388853]
Potency 0.7079qHTS assay for environmental chemicals that activate the Aryl hydrocarbon Receptor (AhR) signaling pathway [AID651777, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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14
[SID17388853]
Potency 0.7208Biochemical firefly luciferase enzyme assay for NPC [AID624030, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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15
[SID103479736]
MIC 0.8Antimicrobial activity against Campylobacter jejuni [AID484859, Type: Literature]
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16
[SID103479736]
EC50 1.2Antiviral activity against HCV genotype 1b in NTZ-11 replicon cell after 4 days by blot hybridization analysis [AID533314, Type: Literature]
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17
[SID103479736]
IC50 1.214Antiprotozoan activity against Giardia intestinalis IMSS:0696:1 trophozoites after 48 hrs [AID598281, Type: Literature]
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18
[SID17388853]
Potency 1.2589qHTS Assay for Anthrax Lethal Toxin Internalization [AID912, Type: confirmatory]lethal factor [Bacillus anthracis str. A2012] [gi:21392848]
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19
[SID103479736]
EC50 1.5Antiviral activity against HCV genotype 1b in TIZ-9 replicon cell after 4 days by blot hybridization analysis [AID533315, Type: Literature]
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20
[SID103479736]
Ki 2.2Inhibition of PFOR Trichomonas vaginalis [AID283185, Type: Literature]
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21
[SID26719875]
Potency 3.1623qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction [AID1461, Type: confirmatory]NPSR1 gene product [Homo sapiens] [gi:46395496]
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22
[SID26719875]
Potency 3.1623qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction [AID1461, Type: confirmatory]NPSR1 gene product [Homo sapiens] [gi:46395496]
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23
[SID103479736]
IC50 3.25Antiparasitic activity against Cryptosporidium parvum in HCT8 cells [AID260527, Type: Literature]
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24
[SID103479736]
IC50 3.8Antimicrobial activity against Cryptosporidium parvum infected in human HCT-8 cells [AID572366, Type: Literature]
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25
[SID103479736]
IC50 3.89Antimalarial activity against Plasmodium berghei schizonts isolated from parasitized erythrocytes infected Wistar rat measured 16 hrs post compound exposure [AID598286, Type: Literature]
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26
[SID103479736]
Ki 4.5Inhibition of PFOR Helicobacter pylori [AID283187, Type: Literature]
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27
[SID103479736]
IC50 6.18Antileishmanial activity against Leishmania mexicana MHOM/MX/ISETGS promastigotes after 72 hrs by neubauer chamber [AID598284, Type: Literature]
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28
[SID17388853]
Potency 6.6824qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 5 hr assay [AID651755, Type: confirmatory]
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29
[SID26719875]
Potency 6.7456qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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30
[SID17388853]
Potency 7.4978qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 1 hr assay [AID651754, Type: confirmatory]
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31
[SID17388853]
Potency 7.9433qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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32
[SID17388853]
Potency 7.9433qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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33
[SID17388853]
Potency 7.9433qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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34
[SID103479736]
Ki 10Inhibition of PFOR Entamoeba histolytica [AID283186, Type: Literature]
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35
[SID103479736]
Ki 10.5Inhibition of PFOR Campylobacter jejuni [AID283188, Type: Literature]
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36
[SID26719875]
Potency 11.2202qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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37
[SID26719875]
Potency 11.2202qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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38
[SID26719875]
Potency 12.5893qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK) [AID1721, Type: confirmatory]pyruvate kinase [Leishmania mexicana mexicana] [gi:290753097]
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39
[SID17388853]
Potency 12.5893qHTS assay for small molecule activators of the p53 signaling pathway [AID651743, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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40
[SID17388853]
Potency 12.5893qHTS assay for small molecule activators of the p53 signaling pathway [AID651743, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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41
[SID17388853]
Potency 12.5893qHTS assay for small molecule activators of the p53 signaling pathway [AID651743, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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42
[SID17388853]
Potency 12.5893qHTS assay for small molecule activators of the p53 signaling pathway [AID651743, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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43
[SID17388853]
Potency 12.5893qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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44
[SID17388853]
Potency 12.5893qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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45
[SID17388853]
Potency 12.5893Cell Viability - LYMP1-003 - Assay at 40 hr [AID964, Type: confirmatory]
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46
[SID103479736]
MIC 13Antimicrobial activity against Helicobacter pylori [AID484858, Type: Literature]
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47
[SID26719875]
Potency 14.1254qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase [AID1634, Type: confirmatory]PKM gene product [Homo sapiens] [gi:33286418]
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48
[SID26719875]
Potency 14.1254qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase [AID1634, Type: confirmatory]PKM gene product [Homo sapiens] [gi:33286418]
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49
[SID26719875]
Potency 14.1254qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase [AID1634, Type: confirmatory]PKM gene product [Homo sapiens] [gi:33286418]
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50
[SID103479736]
IC50 18.73Antitrypanosomal activity against Trypanosoma cruzi MHOM/MX/1994/Ninoa epimastigotes after 72 hrs by neubauer chamber [AID598285, Type: Literature]
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