Metoclopramide (CID 4168) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(55)
 
 
Inactive(350)
 
 
Inconclusive(41)
 
 
Unspecified(301)
 
 
Top Targets:
p450(29)
 
 
 
 
 
7TM GPCR Srx(16)
 
 
 
 
 
7TM GPCR Srsx(14)
 
 
 
 
PLN02808(6)
 
 
STKc ERK1 2 l..(5)
 
 
 
BioAssay Types:
Literature(277)
 
 
 
 
 
Confirmatory(256)
 
 
 
 
Screening(24)
 
 
BioActivity Types:
Potency(209)
 
 
 
IC50(149)
 
 
 
 
Ki(21)
 
 
 
Kd(4)
 
 
EC50(2)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 568    Data Row: 747   Total Pages: 15   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103170845]
EC50 0.00575-hydroxytryptamine 4 receptor agonist activity, concentration which gave 50% increase in the response to electrically-stimulated myenteric plexus and longitudinal muscle of the guinea pig ileum [AID6142, Type: Literature]
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2
[SID103170845]
Ki 0.027Displacement of [125I]iodosulpiride from human Dopamine receptor D3 expressed in CHO cells [AID65133, Type: Literature]D(3) dopamine receptor [gi:1169206]
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3
[SID103170845]
Ki 0.027Displacement of [125I]iodosulpiride from human Dopamine receptor D3 expressed in CHO cells [AID65133, Type: Literature]D(3) dopamine receptor [gi:1169206]
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4
[SID103170845]
Ki 0.027Displacement of [125I]iodosulpiride from human Dopamine receptor D3 expressed in CHO cells [AID65133, Type: Literature]D(3) dopamine receptor [gi:1169206]
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5
[SID103170845]
Ki 0.027Displacement of [125I]iodosulpiride from human Dopamine receptor D3 expressed in CHO cells [AID65133, Type: Literature]D(3) dopamine receptor [gi:1169206]
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6
[SID103170845]
Kd 0.05012Potency at neuronal 5-hydroxytryptamine 3 receptors in the rabbit heart [AID6028, Type: Literature]
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7
[SID103170845]
Kd 0.05012Antagonistic activity against Serotonin 5-hydroxytryptamine 3 receptor in isolated rabbit vagus nerve (RVN) [AID6034, Type: other]
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8
[SID103170845]
IC50 0.0613Concentration of compound required to inhibit the binding of radioligand [3H](R)-7-OH-DPAT to Dopamine receptor D3 in rat striatum [AID65470, Type: Literature]
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9
[SID103170845]
Kd 0.07943Evaluated for the antagonistic activity against Serotonin 5-hydroxytryptamine 3 receptor in isolated perfused rabbit heart (RH) [AID6033, Type: other]
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10
[SID103170845]
Ki 0.08Compound was evaluated for the binding affinity at Dopamine receptor D2 [AID62332, Type: Literature]
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11
[SID103170845]
Ki 0.104Compound was evaluated for binding affinity towards DA D-2 receptor using radioligand [3H]SPI [AID65260, Type: Literature]
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12
[SID103170845]
Ki 0.113Binding affinity to dopamine receptor D2 [AID65098, Type: Literature]
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13
[SID103170845]
IC50 0.127DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) [AID625253, Type: other]D(2) dopamine receptor [gi:118206]
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14
[SID103170845]
IC50 0.127DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) [AID625253, Type: other]D(2) dopamine receptor [gi:118206]
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15
[SID103170845]
IC50 0.127DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) [AID625253, Type: other]D(2) dopamine receptor [gi:118206]
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16
[SID103170845]
IC50 0.127DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) [AID625253, Type: other]D(2) dopamine receptor [gi:118206]
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17
[SID103170845]
IC50 0.127DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) [AID625253, Type: other]D(2) dopamine receptor [gi:118206]
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18
[SID103170845]
IC50 0.2DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) [AID625254, Type: other]D(3) dopamine receptor [gi:1169206]
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19
[SID103170845]
IC50 0.2DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) [AID625254, Type: other]D(3) dopamine receptor [gi:1169206]
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20
[SID103170845]
IC50 0.2DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) [AID625254, Type: other]D(3) dopamine receptor [gi:1169206]
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21
[SID103170845]
IC50 0.2DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) [AID625254, Type: other]D(3) dopamine receptor [gi:1169206]
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22
[SID103170845]
Ki 0.2Compound was evaluated for the binding affinity at 5- HT3 receptor subtype [AID6006, Type: Literature]
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23
[SID103170845]
Ki 0.21Inhibition of [3H]GR-65630 binding to rat cortical membrane serotonin 5-hydroxytryptamine 3 receptor [AID6133, Type: Literature]5-hydroxytryptamine receptor 3A [gi:1168223]
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24
[SID103170845]
IC50 0.228Concentration required to inhibit the binding of radioligand [3H]GR-65630 to serotonin 5-hydroxytryptamine-3 receptor (5-HT 3 receptor)in rat brain cortical membrane [AID6066, Type: Literature]
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25
[SID103170845]
Ki 0.24Inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor [AID5903, Type: Literature]5-hydroxytryptamine receptor 3A [gi:1168223]
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26
[SID103170845]
Ki 0.285Binding affinity against Dopamine receptor D2 using [3H]spiperone as radioligand in rat striatum [AID65106, Type: other]
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27
[SID103170845]
Ki 0.303Affinity towards Dopamine receptor D2 in rat striatum using [3H]spiperone as radioligand [AID64938, Type: Literature]D(2) dopamine receptor [gi:47117674]
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28
[SID103170845]
Ki 0.348Compound was evaluated for its binding affinity for 5-hydroxytryptamine 3 receptor by measuring displacement [3H]GR-65630 in rat cerebral cortex [AID5891, Type: Literature]
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29
[SID103170845]
Ki 0.443Binding affinity against 5-hydroxytryptamine 3 receptor using [3H]BRL-43694 as radioligand in rat posterior cortex [AID5876, Type: other]
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30
[SID103170845]
Ki 0.443Binding affinity against 5-hydroxytryptamine 3 receptor using [3H]BRL-43694 in rat posterior cortex [AID5875, Type: other]5-hydroxytryptamine receptor 3A [gi:1168223]
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31
[SID103170845]
IC50 0.444Concentration of compound required to inhibit the binding of radioligand [3H]spiperone to Dopamine receptor D2 in rat brain synaptic membrane [AID64274, Type: Literature]
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32
[SID103170845]
IC50 0.48Binding affinity against dopamine D2 receptor in rat brain synaptic membrane using [3H]-spiperone as radioligand [AID61325, Type: Literature]
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33
[SID103170845]
IC50 0.48Inhibition of [3H]- spiperone binding to rat brain Dopamine receptor D2 [AID61539, Type: Literature]D(2) dopamine receptor [gi:47117674]
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34
[SID103170845]
Ki 0.49Binding affinity at 5-hydroxytryptamine 3 receptor in rat entorhinal cortex by [3H]BRL-43694 displacement. [AID5888, Type: other]
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35
[SID103170845]
Ki 0.502Inhibitory activity against 5-hydroxytryptamine 3 receptor in rat cortical membranes using [3H]- 1-Methyl-1H-indazole-3-carboxylic acid (8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-amide as a radioligand [AID5898, Type: Literature]
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36
[SID103170845]
Ki 0.546Inhibition of [3H]GR-113808 binding to guinea pig striatum 5-hydroxytryptamine 4 receptor [AID6174, Type: Literature]
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37
[SID103170845]
IC50 0.565In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding [AID64290, Type: Literature]
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38
[SID103170845]
IC50 0.63Inhibitory activity against dopamine receptor D2 by 3H ligand binding experiments. [AID64457, Type: Literature]
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39
[SID103170845]
IC50 0.63DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625217, Type: other]5-hydroxytryptamine receptor 2B [gi:1168220]
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40
[SID103170845]
IC50 0.63DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625217, Type: other]5-hydroxytryptamine receptor 2B [gi:1168220]
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41
[SID103170845]
IC50 0.63DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625217, Type: other]5-hydroxytryptamine receptor 2B [gi:1168220]
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42
[SID103170845]
IC50 0.708DRUGMATRIX: Imidazoline I2, Central radioligand binding (ligand: [3H] Idazoxan) [AID625272, Type: other]
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43
[SID103170845]
IC50 0.8DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625249, Type: other]Cytochrome P450 2D6 [gi:84028191]
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44
[SID103170845]
IC50 0.8DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625249, Type: other]Cytochrome P450 2D6 [gi:84028191]
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45
[SID103170845]
IC50 0.82Inhibitory concentration required for displacing radioligand [3H]SPI from DA D-2 receptor [AID64596, Type: Literature]
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46
[SID103170845]
IC50 0.88Binding affinity against 5-hydroxytryptamine 3 receptor in rat cortical membrane using [3H]GR-65630 as radioligand [AID6063, Type: Literature]
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47
[SID103170845]
IC50 0.88Inhibition of [3H]GR-65630 binding to rat cortical membrane 5-hydroxytryptamine 3 receptor [AID6059, Type: Literature]5-hydroxytryptamine receptor 3A [gi:1168223]
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48
[SID103170845]
Ki 0.9Binding affinity at 5-hydroxytryptamine 4 receptor in rat striatum by [3H]GR-113808 displacement. [AID6243, Type: other]
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49
[SID103170845]
IC50 0.912Concentration of compound required to inhibit the binding of radioligand [3H]GR-113808 to serotonin 5-hydroxytryptamine 4 receptor in guinea-pig striatum [AID6164, Type: Literature]
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50
[SID103170845]
Ki 0.974Binding affinity against 5-hydroxytryptamine 4 receptor using [3H]GR-113808 as radioligand in rat striatum [AID6241, Type: other]
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