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Metoclopramide (CID 4168) - Compound BioActivity Data
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BioActivity Outcomes:
Active(60)
 
 
Inactive(465)
 
 
Inconclusive(44)
 
 
Unspecified(352)
 
 
Top Targets:
7tm 4(44)
 
 
 
 
 
p450(29)
 
 
 
 
 
TAS2R(13)
 
 
 
 
Neur chan LBD(10)
 
 
 
NR LBD ER(9)
 
 
 
BioAssay Types:
Confirmatory(478)
 
 
 
 
 
Literature(307)
 
 
 
 
 
Summary(24)
 
 
Screening(23)
 
 
BioActivity Types:
Potency(317)
 
 
 
IC50(151)
 
 
 
 
 
Ki(24)
 
 
 
Kd(4)
 
 
EC50(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 717    Data Row: 921   Total Pages: 47   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103170845]
EC50 0.00575-hydroxytryptamine 4 receptor agonist activity, concentration which gave 50% increase in the response to electrically-stimulated myenteric plexus and longitudinal muscle of the guinea pig ileum [AID6142, Type: Literature]5-hydroxytryptamine receptor 4 [gi:6224984]
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2
[SID103170845]
Ki 0.027Displacement of [125I]iodosulpiride from human Dopamine receptor D3 expressed in CHO cells [AID65133, Type: Literature]D(3) dopamine receptor [gi:1169206]
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3
[SID103170845]
Kd 0.05012Antagonistic activity against Serotonin 5-hydroxytryptamine 3 receptor in isolated rabbit vagus nerve (RVN) [AID6034, Type: confirmatory]
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4
[SID103170845]
Kd 0.05012Potency at neuronal 5-hydroxytryptamine 3 receptors in the rabbit heart [AID6028, Type: Literature]
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5
[SID103170845]
IC50 0.0613Concentration of compound required to inhibit the binding of radioligand [3H](R)-7-OH-DPAT to Dopamine receptor D3 in rat striatum [AID65470, Type: Literature]
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6
[SID103170845]
Kd 0.07943Evaluated for the antagonistic activity against Serotonin 5-hydroxytryptamine 3 receptor in isolated perfused rabbit heart (RH) [AID6033, Type: confirmatory]
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7
[SID103170845]
Ki 0.08Compound was evaluated for the binding affinity at Dopamine receptor D2 [AID62332, Type: Literature]
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8
[SID103170845]
Ki 0.104Compound was evaluated for binding affinity towards DA D-2 receptor using radioligand [3H]SPI [AID65260, Type: Literature]
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9
[SID103170845]
Ki 0.113Binding affinity to dopamine receptor D2 [AID65098, Type: Literature]
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10
[SID103170845]
IC50 0.127DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) [AID625253, Type: confirmatory]D(2) dopamine receptor [gi:118206]
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11
[SID103170845]
IC50 0.2DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) [AID625254, Type: confirmatory]D(3) dopamine receptor [gi:1169206]
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12
[SID103170845]
Ki 0.2Compound was evaluated for the binding affinity at 5- HT3 receptor subtype [AID6006, Type: Literature]
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13
[SID103170845]
Ki 0.21Inhibition of [3H]GR-65630 binding to rat cortical membrane serotonin 5-hydroxytryptamine 3 receptor [AID6133, Type: Literature]5-hydroxytryptamine receptor 3A [gi:1168223]
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14
[SID103170845]
Ki 0.21Inhibition of [3H]GR-65630 binding to rat cortical membrane serotonin 5-hydroxytryptamine 3 receptor [AID6133, Type: Literature]5-hydroxytryptamine receptor 3B [gi:81868595]
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15
[SID103170845]
IC50 0.228Concentration required to inhibit the binding of radioligand [3H]GR-65630 to serotonin 5-hydroxytryptamine-3 receptor (5-HT 3 receptor)in rat brain cortical membrane [AID6066, Type: Literature]
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16
[SID103170845]
Ki 0.24Inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor [AID5903, Type: Literature]5-hydroxytryptamine receptor 3A [gi:1168223]
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17
[SID103170845]
Ki 0.24Inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor [AID5903, Type: Literature]5-hydroxytryptamine receptor 3B [gi:81868595]
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18
[SID103170845]
Ki 0.285Binding affinity against Dopamine receptor D2 using [3H]spiperone as radioligand in rat striatum [AID65106, Type: confirmatory]
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19
[SID103170845]
Ki 0.303Affinity towards Dopamine receptor D2 in rat striatum using [3H]spiperone as radioligand [AID64938, Type: Literature]D(2) dopamine receptor [gi:47117674]
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20
[SID103170845]
Ki 0.348Compound was evaluated for its binding affinity for 5-hydroxytryptamine 3 receptor by measuring displacement [3H]GR-65630 in rat cerebral cortex [AID5891, Type: Literature]
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