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Methylphenidate (CID 4158) - Compound BioActivity Data
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BioActivity Outcomes:
Active(14)
 
 
Inactive(2)
 
 
Inconclusive(16)
 
 
Unspecified(54)
 
 
Top Targets:
SLC6sbd DAT1(6)
 
 
 
SLC6sbd NET(3)
 
 
 
NAD binding 8(2)
 
 
p450(1)
 
 
BioAssay Types:
Literature(83)
 
 
 
 
 
BioActivity Types:
IC50(24)
 
 
 
 
Ki(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 84    Data Row: 86   Total Pages: 5   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103209574]
IC50 0.017Inhibition of [3H]WIN-35428 Binding to the Dopamine Transporter in Rhesus (Macaca mulatta) orCynomolgus Monkey (Macaca fascicularis) Caudate-Putamen [AID64208, Type: Literature]
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2
[SID103209574]
IC50 0.061Inhibition of [3H]NE uptake into human NET expressing HEK293 cells [AID275446, Type: Literature]
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3
[SID103209574]
IC50 0.079Inhibition of [3H]DA uptake at human DAT expressing HEK293 cells [AID275442, Type: Literature]Sodium-dependent dopamine transporter [gi:266667]
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4
[SID103209574]
IC50 0.083Tested for the ability to bind stereoselectively and enantioselectively to the dopamine transporter (DAT); Value ranges from 34 - 83 nM [AID65807, Type: Literature]
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5
[SID103209574]
Ki 0.11Displacement of [125I]RTI-55 from human DAT expressing HEK293 cells [AID275441, Type: Literature]Sodium-dependent dopamine transporter [gi:266667]
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6
[SID103209574]
IC50 0.171Ability to inhibit the uptake of norepinephrine [3H]-NE in to rat brain synaptosomes [AID195888, Type: Literature]
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7
[SID103209574]
IC50 0.438Ability to inhibit the uptake of dopamine [3H]DA in to rat brain synaptosomes [AID195887, Type: Literature]
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8
[SID103209574]
Ki 0.66Displacement of [125I]RTI-55 from human NET expressing HEK293 cells [AID275445, Type: Literature]
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9
[SID103209574]
IC50 5.1Inhibition of [3H]5-HT uptake into human SERT expressing HEK293 cells [AID275444, Type: Literature]
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10
[SID103209574]
Norepinephrine transporter inhibitor [AID742957, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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11
[SID103858000]
Wombat Data for BeliefDocking [AID493017, Type: Literature] [geneid:6531]
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12
[SID103209574]
Dopamine transporter inhibitor [AID742915, Type: Literature]Sodium-dependent dopamine transporter [gi:266667]
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13
[SID48416258]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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14
[SID85209963]
Ligands of bioamine (Class A) GPCRs [AID2062, Type: other]
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15
[SID103209574]
Ki 65Displacement of [125I]RTI-55 from human SERT expressing HEK293 cells [AID275443, Type: Literature]
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16
[SID103209574]
IC50 100Inhibition of [3H]citalopram Binding to the Serotonin Transporter in Rhesus (Macaca mulatta) or Cynomolgus Monkey (Macaca fascicularis) Caudate-Putamen [AID203945, Type: Literature]
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17
[SID103209574]
Total body clearance in human [AID425652, Type: Literature]
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18
[SID103209574]
Renal clearance in human [AID425653, Type: Literature]
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19
[SID103209574]
Solubility of the compound in 0.1 M phosphate buffer at 600 uM at pH 7.4 after 24 hrs by LC/MS/MS analysis [AID539464, Type: Literature]
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20
[SID103209574]
Volume of distribution at steady state in human after iv administration [AID540209, Type: Literature]
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