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CHEMBL262079 (CID 4131581) - Compound BioActivity Data
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BioActivity Outcomes:
Probe(1)
 
 
Active(5)
 
 
Inactive(193)
 
 
Unspecified(2)
 
 
Top Targets:
7tm 4(17)
 
 
RasGEF(4)
 
 
Anthrax-tox M(3)
 
 
NR DBD CAR(3)
 
 
Toxin trans(3)
 
 
BioAssay Types:
Screening(148)
 
 
 
Confirmatory(34)
 
 
Literature(15)
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(34)
 
 
IC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 187    Data Row: 201   Total Pages: 11   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID46499821]
Summary of probe development efforts to identify inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1). [AID1844, Type: summary]steroidogenic factor-1 [Homo sapiens] [gi:216409744]
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2
[SID103565115]
IC50 0.2Inhibition of GAL4-tagged NR5A1 by luciferase assay [AID329653, Type: Literature]
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3
[SID103565115]
IC50 0.2Inverse agonist activity at SF-1 [AID593523, Type: Literature]
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4
[SID103565115]
Antiproliferative activity against SF-1 negative human SW13 cells [AID593524, Type: Literature]
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5
[SID103565115]
Inhibition of doxycycline induced proliferation in human NCI-H295RR cells [AID593525, Type: Literature]
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6
[SID99495561]
qHTS for Inhibitors of Inflammasome Signaling: IL-1-beta AlphaLISA Primary Screen [AID743279, Type: screening]interleukin-1 beta proprotein [Homo sapiens] [gi:10835145]
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7
[SID103565115]
Inhibition of GAL4-tagged RORalpha at 100 uM by luciferase assay [AID329656, Type: Literature]
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8
[SID103565115]
Inhibition of HSV1 GAL4-tagged VP16 at 100 uM by luciferase assay [AID329658, Type: Literature]
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9
[SID99495561]
Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis: Absorbance-based biochemical high throughput Glycerophosphate Dehydrogenase-Triosephosphate Isomerase (GDH-TPI) full deck assay to identify assay artifacts [AID588335, Type: screening]
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10
[SID99495561]
Cholera Quorum: HTS for inducers of light production in the absence ofautoinducers using BH1578 (luxS deficient, cqsA deficient) Measured in Microorganism System Using Plate Reader - 2132-01_Agonist_SinglePoint_HTS_Activity [AID588436, Type: screening]
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11
[SID99495561]
uHTS identification of small molecule modulators of myocardial damage [AID588492, Type: screening]
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12
[SID99495561]
Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID588674, Type: screening]
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13
[SID99495561]
Luciferase Reporter Cell Based HTS to identify inhibitors of N-linked Glycosylation Measured in Cell-Based System Using Plate Reader - 2146-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID588692, Type: screening]
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14
[SID99495561]
Potency qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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15
[SID99495561]
Identification of inhibitors of RAD54 Measured in Biochemical System Using Plate Reader - 2159-01_Inhibitor_SinglePoint_HTS_Activity [AID602329, Type: screening]DNA repair and recombination protein RAD54-like [Homo sapiens] [gi:216548193]
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16
[SID99495561]
Fluorescence-based biochemical high throughput primary assay to identify inhibitors of phospholipase C isozymes (PLC-gamma1). [AID720700, Type: screening]Phospholipase C, gamma 1 [Homo sapiens] [gi:223459640]
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17
[SID99495561]
uHTS identification of Caspase-8 TRAIL sensitizers in a luminesence assay [AID624354, Type: screening]tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens] [gi:224494019]
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18
[SID99495561]
uHTS Fluorescent Assay Using Nedd8 Protein Substrate for Identification of Inhibitors of Sentrin-Specific Protease 8 (SENP8) [AID602440, Type: screening]sentrin-specific protease 8 [Homo sapiens] [gi:262118306]
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19
[SID99495561]
Screen for inhibitors of the SWI/SNF chromatin remodeling complex (esBAF) in mouse embryonic stem cells with Luciferase reporter assay Measured in Cell-Based System Using Plate Reader - 2141-01_Inhibitor_SinglePoint_HTS_Activity [AID602393, Type: screening]transcription activator BRG1 isoform 1 [Mus musculus] [gi:291463269]
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20
[SID99495561]
Potency qHTS of PTHR Inhibitors: Primary Screen [AID743266, Type: confirmatory]parathyroid hormone/parathyroid hormone-related peptide receptor precursor [Homo sapiens] [gi:296080761]
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