NSC 23766 (CID 409805) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(2)
 
 
Inactive(18)
 
 
Unspecified(2)
 
 
Top Targets:
Rac1 like(3)
 
 
 
HLH(1)
 
 
HpcH HpaI(1)
 
 
MSH6 like(1)
 
 
Myc N(1)
 
 
BioAssay Types:
Confirmatory(9)
 
 
Screening(8)
 
 
Literature(5)
 
 
 
 
BioActivity Types:
Potency(9)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 22    Data Row: 22   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103562674]
 Inhibition of Rac1 binding to Pak1 in human aortic smooth muscle cells at 100 uM by SDS-PAGE based chemiluminescence [AID421043, Type: Literature]Ras-related C3 botulinum toxin substrate 1 [gi:51702787]
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2
[SID103562674]
 Inhibition of Rac1 binding to Pak1 in human aortic smooth muscle cells at 100 uM by SDS-PAGE based chemiluminescence [AID421043, Type: Literature]Ras-related C3 botulinum toxin substrate 1 [gi:51702787]
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3
[SID103562674]
 Inhibition of Rac1 binding to Pak1 in human aortic smooth muscle cells at 50 uM by SDS-PAGE based chemiluminescence [AID421042, Type: Literature]Ras-related C3 botulinum toxin substrate 1 [gi:51702787]
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4
[SID103562674]
 Inhibition of Rac1 binding to Pak1 in human aortic smooth muscle cells at 50 uM by SDS-PAGE based chemiluminescence [AID421042, Type: Literature]Ras-related C3 botulinum toxin substrate 1 [gi:51702787]
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5
[SID103562674]
 Inhibition of PDGF-BB-stimulated Rac1 activity in human aortic smooth muscle cells assessed as reduction of Rac1GTP level at 50 uM after 4 hrs by G-LISA relative to control [AID421035, Type: Literature]Ras-related C3 botulinum toxin substrate 1 [gi:51702787]
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6
[SID103562674]
 Inhibition of PDGF-BB-stimulated Rac1 activity in human aortic smooth muscle cells assessed as reduction of Rac1GTP level at 50 uM after 4 hrs by G-LISA relative to control [AID421035, Type: Literature]Ras-related C3 botulinum toxin substrate 1 [gi:51702787]
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7
[SID103562674]
 Binding affinity to Rac [AID318579, Type: Literature]
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8
[SID124891583]
Potency 29.5659Cell Proliferation Assay against a hMSC Cell Line [AID651696, Type: confirmatory]
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9
[SID124891583]
Potency 37.2212Cell Proliferation Assay against the HBL1 Cell Line [AID651646, Type: confirmatory]
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10
[SID124891583]
Potency 41.7629Cell Proliferation Assay against the TMD8 Cell Line [AID651645, Type: confirmatory]
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11
[SID124891583]
Potency qHTS of Trypanosoma Brucei Inhibitors [AID624173, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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12
[SID85788688]
 SMM ID4 Measured in Biochemical System Using Small Molecule MicroArray - 2128-01_Other_SinglePoint_HTS_Activity [AID624137, Type: screening]Id4 [Homo sapiens] [gi:881546]
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13
[SID85788688]
 Development of IDH1/2 inhibitors (CTD2project) Measured in Biochemical System Using Plate Reader - 2107-01_Inhibitor_SinglePoint_HTS_Activity [AID624101, Type: screening]Isocitrate dehydrogenase 1 (NADP+), soluble [Homo sapiens] [gi:62203298]
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14
[SID85788688]
 Development of IDH1/2 inhibitors (CTD2project) Measured in Biochemical System Using Plate Reader - 2107-01_Inhibitor_SinglePoint_HTS_Activity [AID624101, Type: screening]Isocitrate dehydrogenase 1 (NADP+), soluble [Homo sapiens] [gi:62203298]
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15
[SID85788688]
 Development of IDH1/2 inhibitors (CTD2project) Measured in Biochemical System Using Plate Reader - 2107-01_Inhibitor_SinglePoint_HTS_Activity [AID624101, Type: screening]Isocitrate dehydrogenase 1 (NADP+), soluble [Homo sapiens] [gi:62203298]
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16
[SID85788688]
 SMM c-myc Measured in Biochemical System Using Small Molecule MicroArray - 2081-01_Other_SinglePoint_HTS_Activity [AID624141, Type: screening]MYC gene product [Homo sapiens] [gi:71774083]
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17
[SID85788688]
 NF-KappaB Measured in Biochemical System Using Small Molecule MicroArray - 2080-01_Other_SinglePoint_HTS_Activity [AID624139, Type: screening]NFKB1 gene product [Homo sapiens] [gi:34577122]
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18
[SID85788688]
 NF-KappaB Measured in Biochemical System Using Small Molecule MicroArray - 2080-01_Other_SinglePoint_HTS_Activity [AID624139, Type: screening]NFKB1 gene product [Homo sapiens] [gi:34577122]
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19
[SID85788688]
 NF-KappaB Measured in Biochemical System Using Small Molecule MicroArray - 2080-01_Other_SinglePoint_HTS_Activity [AID624139, Type: screening]NFKB1 gene product [Homo sapiens] [gi:34577122]
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20
[SID85788688]
 NF-KappaB Measured in Biochemical System Using Small Molecule MicroArray - 2080-01_Other_SinglePoint_HTS_Activity [AID624139, Type: screening]NFKB1 gene product [Homo sapiens] [gi:34577122]
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21
[SID85788688]
 SMM STAT-3 Measured in Biochemical System Using Small Molecule MicroArray - 2076-01_Other_SinglePoint_HTS_Activity_Set2 [AID624138, Type: screening]STAT3 gene product [Homo sapiens] [gi:21618340]
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22
[SID85788688]
 SMM STAT-3 Measured in Biochemical System Using Small Molecule MicroArray - 2076-01_Other_SinglePoint_HTS_Activity_Set2 [AID624138, Type: screening]STAT3 gene product [Homo sapiens] [gi:21618340]
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23
[SID85788688]
 SMM STAT-3 Measured in Biochemical System Using Small Molecule MicroArray - 2076-01_Other_SinglePoint_HTS_Activity_Set2 [AID624138, Type: screening]STAT3 gene product [Homo sapiens] [gi:21618340]
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24
[SID85788688]
 mutant P53 Measured in Biochemical System Using Small Molecule MicroArray - 2077-01_Other_SinglePoint_HTS_Activity [AID624136, Type: screening]mutant p53 [Homo sapiens] [gi:208342286]
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25
[SID85788688]
 mutant P53 Measured in Biochemical System Using Small Molecule MicroArray - 2077-01_Other_SinglePoint_HTS_Activity [AID624136, Type: screening]mutant p53 [Homo sapiens] [gi:208342286]
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26
[SID85788688]
 mutant P53 Measured in Biochemical System Using Small Molecule MicroArray - 2077-01_Other_SinglePoint_HTS_Activity [AID624136, Type: screening]mutant p53 [Homo sapiens] [gi:208342286]
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27
[SID85788688]
 mutant P53 Measured in Biochemical System Using Small Molecule MicroArray - 2077-01_Other_SinglePoint_HTS_Activity [AID624136, Type: screening]mutant p53 [Homo sapiens] [gi:208342286]
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28
[SID85788688]
 NSD2 Inhibitors Measured in Biochemical System Using Plate Reader - 2115-01_Inhibitor_SinglePoint_HTS_Activity [AID624260, Type: screening]WHSC1 gene product [Homo sapiens] [gi:109633019]
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29
[SID85788688]
 Luminescence Cell-Based Primary HTS to Identify Re-Activators of the P53 Mutant Pathway Measured in Cell-Based System Using Plate Reader - 2071-01_Activator_SinglePoint_HTS_Activity [AID624151, Type: screening]
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30
[SID124891583]
Potency Cytotoxicity counterscreen for NFkB agonists and antagonists [AID624476, Type: confirmatory]
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31
[SID124891583]
Potency qHTS Assay for Identification of Small Molecule Agonists for NFkB Signaling Pathway. [AID624478, Type: confirmatory]
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32
[SID124891583]
Potency qHTS Assay for Identification of Small Molecule Antagonists for NFkB Signaling Pathway. [AID624479, Type: confirmatory]
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33
[SID124891583]
Potency Cell Proliferation Assay against the TMD8 Cell Line (Caspase readout at 16 hrs) [AID651712, Type: confirmatory]
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34
[SID124891583]
Potency Cell Proliferation Assay against the TMD8 Cell Line (Caspase readout at 8 hrs) [AID651713, Type: confirmatory]
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35
[SID103562674]
 Inhibition of Rac1 61L mutant-induced cellular transformation in mouse NIH3T3 cells at 5 uM after 3 to 5 weeks [AID385659, Type: Literature]
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