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NSC 23766 (CID 409805) - Compound BioActivity Data
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BioActivity Outcomes:
Active(2)
 
 
Inactive(26)
 
 
Unspecified(2)
 
 
Top Targets:
Rac1 like(3)
 
 
 
Myc N(1)
 
 
MSH6 like(1)
 
 
STAT bind(1)
 
 
P53(1)
 
 
BioAssay Types:
Confirmatory(16)
 
 
Screening(8)
 
 
Literature(6)
 
 
 
 
BioActivity Types:
Potency(17)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 30    Data Row: 30   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103562674]
Inhibition of Rac1 binding to Pak1 in human aortic smooth muscle cells at 50 uM by SDS-PAGE based chemiluminescence [AID421042, Type: Literature]Ras-related C3 botulinum toxin substrate 1 [gi:51702787]
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2
[SID103562674]
Inhibition of Rac1 binding to Pak1 in human aortic smooth muscle cells at 100 uM by SDS-PAGE based chemiluminescence [AID421043, Type: Literature]Ras-related C3 botulinum toxin substrate 1 [gi:51702787]
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3
[SID103562674]
Binding affinity to Rac [AID318579, Type: Literature]
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4
[SID103562674]
Inhibition of PDGF-BB-stimulated Rac1 activity in human aortic smooth muscle cells assessed as reduction of Rac1GTP level at 50 uM after 4 hrs by G-LISA relative to control [AID421035, Type: Literature]Ras-related C3 botulinum toxin substrate 1 [gi:51702787]
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5
[SID124891583]
Potency 29.5659Cell Proliferation Assay against a hMSC Cell Line [AID651696, Type: confirmatory]
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6
[SID124891583]
Potency 37.2212Cell Proliferation Assay against the HBL1 Cell Line [AID651646, Type: confirmatory]
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7
[SID124891583]
Potency 41.7629Cell Proliferation Assay against the TMD8 Cell Line [AID651645, Type: confirmatory]
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8
[SID124891583]
Potency Cell Proliferation Assay against the TMD8 Cell Line (Caspase readout at 16 hrs) [AID651712, Type: confirmatory]
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9
[SID124891583]
Potency Cell Proliferation Assay against the TMD8 Cell Line (Caspase readout at 8 hrs) [AID651713, Type: confirmatory]
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10
[SID124891583]
Potency qHTS profiling for inhibitors of Plasmodium falciparum (3D7) proliferation [AID743322, Type: confirmatory]
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11
[SID124891583]
Potency qHTS profiling for inhibitors of Plasmodium falciparum (DD2) proliferation [AID743323, Type: confirmatory]
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12
[SID124891583]
Potency qHTS profiling for inhibitors of Plasmodium falciparum (HB3) proliferation [AID743324, Type: confirmatory]
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13
[SID124891583]
Potency qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (3D7) proliferation [AID743344, Type: confirmatory]
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14
[SID124891583]
Potency qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (DD2) proliferation [AID743345, Type: confirmatory]
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15
[SID124891583]
Potency qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (DD2) proliferation (Rep 2) [AID743346, Type: confirmatory]
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16
[SID124891583]
Potency qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (HB3) proliferation [AID743347, Type: confirmatory]
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17
[SID85788688]
Luminescence Cell-Based Primary HTS to Identify Re-Activators of the P53 Mutant Pathway Measured in Cell-Based System Using Plate Reader - 2071-01_Activator_SinglePoint_HTS_Activity [AID624151, Type: screening]
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18
[SID85788688]
SMM ID4 Measured in Biochemical System Using Small Molecule MicroArray - 2128-01_Other_SinglePoint_HTS_Activity [AID624137, Type: screening]Id4 [Homo sapiens] [gi:881546]
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19
[SID124891583]
Potency qHTS for small molecule inhibitors of Yes1 kinase: Primary Screen [AID686947, Type: Literature]tyrosine-protein kinase Yes [Homo sapiens] [gi:4885661]
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20
[SID85788688]
SMM STAT-3 Measured in Biochemical System Using Small Molecule MicroArray - 2076-01_Other_SinglePoint_HTS_Activity_Set2 [AID624138, Type: screening]signal transducer and activator of transcription 3 isoform 1 [Homo sapiens] [gi:21618340]
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21
[SID85788688]
NF-KappaB Measured in Biochemical System Using Small Molecule MicroArray - 2080-01_Other_SinglePoint_HTS_Activity [AID624139, Type: screening]nuclear factor NF-kappa-B p105 subunit isoform 1 [Homo sapiens] [gi:34577122]
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22
[SID103562674]
Inhibition of Rac1 61L mutant-induced cellular transformation in mouse NIH3T3 cells at 5 uM after 3 to 5 weeks [AID385659, Type: Literature]
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23
[SID124891583]
Potency Cytotoxicity counterscreen for NFkB agonists and antagonists [AID624476, Type: confirmatory]
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24
[SID124891583]
Potency qHTS Assay for Identification of Small Molecule Agonists for NFkB Signaling Pathway. [AID624478, Type: confirmatory]
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25
[SID124891583]
Potency qHTS Assay for Identification of Small Molecule Antagonists for NFkB Signaling Pathway. [AID624479, Type: confirmatory]
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26
[SID85788688]
Development of IDH1/2 inhibitors (CTD2project) Measured in Biochemical System Using Plate Reader - 2107-01_Inhibitor_SinglePoint_HTS_Activity [AID624101, Type: screening]Isocitrate dehydrogenase 1 (NADP+), soluble [Homo sapiens] [gi:62203298]
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27
[SID124891583]
Potency qHTS of Trypanosoma Brucei Inhibitors [AID624173, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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28
[SID85788688]
SMM c-myc Measured in Biochemical System Using Small Molecule MicroArray - 2081-01_Other_SinglePoint_HTS_Activity [AID624141, Type: screening]myc proto-oncogene protein [Homo sapiens] [gi:71774083]
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29
[SID85788688]
NSD2 Inhibitors Measured in Biochemical System Using Plate Reader - 2115-01_Inhibitor_SinglePoint_HTS_Activity [AID624260, Type: screening]histone-lysine N-methyltransferase NSD2 isoform 1 [Homo sapiens] [gi:109633019]
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30
[SID85788688]
mutant P53 Measured in Biochemical System Using Small Molecule MicroArray - 2077-01_Other_SinglePoint_HTS_Activity [AID624136, Type: screening]mutant p53 [Homo sapiens] [gi:208342286]
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