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BioActivity Data for Compound NSC 23766 (CID 409805)

BioActivity Outcomes:
Active(4)
 
 
Inactive(27)
 
 
Inconclusive(1)
 
 
Unspecified(2)
 
 
Top Targets:
Rac1 like(3)
 
 
 
HLH(1)
 
 
MSH6 like(1)
 
 
Myc N(1)
 
 
P53(1)
 
 
BioAssay Types:
Confirmatory(19)
 
 
 
 
Screening(8)
 
 
Literature(6)
 
 
 
 
BioAssay Categories:
Biochemical(12)
 
 
 
 
Toxicity(1)
 
 
Cell-based(2)
 
 
BioActivity Types:
Potency(21)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 34    Data Row: 34   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID124891583]
Potency 18.6548Cell Proliferation Assay Versus the ED40515 IL2 Dependent ATL cell lines [AID1053195, Type: confirmatory]
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2
[SID124891583]
Potency 26.3506Cell Proliferation Assay Versus the ED40515 IL2 Independent ATL cell lines [AID1053194, Type: confirmatory]
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3
[SID103562674]
Inhibition of Rac1 binding to Pak1 in human aortic smooth muscle cells at 100 uM by SDS-PAGE based chemiluminescence [AID421043, Type: Literature]Ras-related C3 botulinum toxin substrate 1 [gi:51702787]
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4
[SID103562674]
Inhibition of Rac1 binding to Pak1 in human aortic smooth muscle cells at 50 uM by SDS-PAGE based chemiluminescence [AID421042, Type: Literature]Ras-related C3 botulinum toxin substrate 1 [gi:51702787]
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5
[SID103562674]
Inhibition of PDGF-BB-stimulated Rac1 activity in human aortic smooth muscle cells assessed as reduction of Rac1GTP level at 50 uM after 4 hrs by G-LISA relative to control [AID421035, Type: Literature]Ras-related C3 botulinum toxin substrate 1 [gi:51702787]
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6
[SID103562674]
Binding affinity to Rac [AID318579, Type: Literature]
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7
[SID124891583]
Potency 29.5659Cell Proliferation Assay against a hMSC Cell Line [AID651696, Type: confirmatory]
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8
[SID124891583]
Potency 37.2212Cell Proliferation Assay against the HBL1 Cell Line [AID651646, Type: confirmatory]
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9
[SID124891583]
Potency 41.7629Cell Proliferation Assay against the TMD8 Cell Line [AID651645, Type: confirmatory]
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10
[SID103562674]
Inhibition of Rac1 61L mutant-induced cellular transformation in mouse NIH3T3 cells at 5 uM after 3 to 5 weeks [AID385659, Type: Literature]
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11
[SID124891583]
Potency qHTS profiling for inhibitors of Plasmodium falciparum (3D7) proliferation [AID743322, Type: confirmatory]
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12
[SID124891583]
Potency qHTS profiling for inhibitors of Plasmodium falciparum (DD2) proliferation [AID743323, Type: confirmatory]
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13
[SID124891583]
Potency qHTS profiling for inhibitors of Plasmodium falciparum (HB3) proliferation [AID743324, Type: confirmatory]
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14
[SID124891583]
Potency qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (3D7) proliferation [AID743344, Type: confirmatory]
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15
[SID124891583]
Potency qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (DD2) proliferation [AID743345, Type: confirmatory]
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16
[SID124891583]
Potency qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (DD2) proliferation (Rep 2) [AID743346, Type: confirmatory]
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17
[SID124891583]
Potency qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (HB3) proliferation [AID743347, Type: confirmatory]
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18
[SID124891583]
Potency Cell Proliferation Assay against the TMD8 Cell Line (Caspase readout at 16 hrs) [AID651712, Type: confirmatory]
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19
[SID124891583]
Potency Cell Proliferation Assay against the TMD8 Cell Line (Caspase readout at 8 hrs) [AID651713, Type: confirmatory]
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20
[SID124891583]
Potency qHTS for small molecule inhibitors of Yes1 kinase: Counter Assay [AID686950, Type: other]
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