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Metformin (CID 4091) - Compound BioActivity Data
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BioActivity Outcomes:
Active(17)
 
 
Inactive(282)
 
 
Inconclusive(27)
 
 
Unspecified(2064)
 
 
Top Targets:
p450(19)
 
 
 
 
7TM GPCR Srx(16)
 
 
7TM GPCR Srsx(15)
 
 
MFS(12)
 
 
NR LBD ER(9)
 
 
 
BioAssay Types:
Confirmatory(884)
 
 
 
 
Literature(348)
 
 
 
 
 
Summary(24)
 
 
 
Screening(4)
 
 
BioActivity Types:
IC50(697)
 
 
 
 
Potency(184)
 
 
 
AC50(2)
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2317    Data Row: 2390   Total Pages: 120   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103508547]
EC50 0.27Increase in glucose consumption in insulin-resistant human HepG2 cells after 24 hrs [AID619463, Type: Literature]
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2
[SID103508547]
IC50 29Inhibition of DPP4 [AID313842, Type: Literature]
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3
[SID48416229]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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4
[SID103508547]
Antidiabetic activity in high fat diet-fed C57BL/6J mouse assessed as decrease in blood glucose level at 250 mg/kg/day, po for 4 weeks measured after 60 mins by intraperitoneal glucose tolerance test [AID615040, Type: Literature]
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5
[SID103508547]
Antidiabetic activity in high fat diet-fed C57BL/6J mouse assessed as decrease in blood glucose level at 250 mg/kg/day, po for 4 weeks measured after 120 mins by intraperitoneal glucose tolerance test [AID615041, Type: Literature]
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6
[SID103508547]
Antidiabetic activity in C57BLKS/J-db/db mouse assessed as reduction of fasting blood glucose level at 250 mg/kg/day, po for 5 weeks [AID615133, Type: Literature]
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7
[SID103508547]
Antidiabetic activity in normal ICR mouse assessed as reduction in plasma glucose level at 200 mg/kg, ip after 60 mins [AID654702, Type: Literature]
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8
[SID103508547]
Antidiabetic activity in STZ-induced ICR mouse T1DM model assessed as reduction in plasma glucose level at 200 mg/kg, ip after 60 mins [AID654703, Type: Literature]
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9
[SID103508547]
Antiproliferative activity against human MDA-MB-231 cells at 1 to 20 mM after 24 hrs by MTT assay [AID658424, Type: Literature]
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10
[SID103508547]
Antiobesity activity in C57BL/6J mouse high fat diet-induced NAFLD model assessed as reduction of postprandial glucose level at 150 mg/kg, po qd for 6 weeks by intravenous glucose tolerance test [AID705073, Type: Literature]
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11
[SID103508547]
Antiobesity activity in C57BL/6J mouse high fat diet-induced NAFLD model assessed as reduction of postprandial glucose level at 150 mg/kg, po qd for 6 weeks by oral glucose tolerance test [AID705075, Type: Literature]
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12
[SID103508547]
Reduction of glucose consumption in insulin-resistant human HepG2 cells at 1 mM after 24 hrs by glucose oxidase method in presence of 0.1 uM of insulin [AID705326, Type: Literature]
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13
[SID103508547]
Reduction of glucose consumption in insulin-resistant human HepG2 cells at 1 mM after 24 hrs by glucose oxidase method in presence of 22.2 mM of glucose [AID705327, Type: Literature]
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14
[SID103508547]
Antiobesity activity in Wistar rat high fat diet-induced NAFLD model assessed as reduction of fat accumulation in liver at 150 mg/kg, po qd for 4 weeks by hematoxylin and eosin staining [AID705285, Type: Literature]
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15
[SID103508547]
Antiobesity activity in C57BL/6J mouse high fat diet-induced NAFLD model assessed as reduction of fat mass in epididymal and abdominal at 150 mg/kg, po qd for 7 weeks [AID705088, Type: Literature]
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16
[SID103508547]
Antiobesity activity in C57BL/6J mouse high fat diet-induced NAFLD model assessed as reduction of liver weight at 150 mg/kg, po qd for 7 weeks [AID705089, Type: Literature]
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17
[SID103508547]
Decrease in TSH level in diabetic non-obese pateint by ELISA relative to untreated obese insulin-resistant control [AID1107062, Type: other]
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18
[SID103508547]
IC50 250Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay [AID721754, Type: Literature]Multidrug and toxin extrusion protein 1 [gi:74731723]
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19
[SID103508547]
Km 377TP_TRANSPORTER: uptake in OCT1-expressing CHO cells [AID679316, Type: Literature]Solute carrier family 22 member 1 [gi:81872095]
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20
[SID103508547]
IC50 378.253SANGER: Inhibition of human KASUMI-1 cell growth in a cell viability assay. [AID742267, Type: confirmatory]
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