2-[2-[(2,3-DIHYDROBENZO[1,4]DIOXIN-6-YLCARBAMOYL)METHYL]-1-OXO-1,2-DIHYDROISOQUINOLIN-5-YLOXY]PROPIONIC ACID ETHYL ESTER (CID 4076092) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Probe(1)
 
 
Active(11)
 
 
Inactive(782)
 
 
Inconclusive(17)
 
 
Unspecified(9)
 
 
Top Targets:
7TM GPCR Srx(25)
 
 
alkPPc(14)
 
 
Tryp SPc(11)
 
 
Bcl-2 like(11)
 
 
7TM GPCR Srsx(11)
 
 
BioAssay Types:
Screening(506)
 
 
 
 
 
Confirmatory(277)
 
 
 
 
 
Literature(13)
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(206)
 
 
 
 
IC50(46)
 
 
 
 
EC50(11)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 800    Data Row: 820   Total Pages: 17   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID7969543]
 Summary of probe development efforts to identify inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1). [AID1844, Type: summary]steroidogenic factor-1 [Homo sapiens] [gi:216409744]
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2
[SID7969543]
 Summary of probe development efforts to identify inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1). [AID1844, Type: summary]steroidogenic factor-1 [Homo sapiens] [gi:216409744]
View
3
[SID7969543]
 Summary of probe development efforts to identify inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1). [AID1844, Type: summary]steroidogenic factor-1 [Homo sapiens] [gi:216409744]
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4
[SID103565235]
IC50 0.76Inhibition of GAL4-tagged NR5A1 by luciferase assay [AID329653, Type: Literature]
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5
[SID7969543]
 Luminescence-based cell-based primary high throughput screening assay to identify activators of the GAA850 frataxin (FXN) promoter [AID540364, Type: screening]
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6
[SID7969543]
 Cell signaling CRE-BLA (Fsk stim) [AID662, Type: confirmatory]
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7
[SID56436610]
 Parallel artificial membrane permeability assay at pH 7.4 [AID624339, Type: other]
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8
[SID7969543]
 HTS of Estrogen Receptor- alpha Coactivator Binding Potentiators [AID639, Type: screening]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
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9
[SID7969543]
 HTS of Estrogen Receptor- alpha Coactivator Binding Potentiators [AID639, Type: screening]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
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10
[SID7969543]
 HTS of Estrogen Receptor- alpha Coactivator Binding Potentiators [AID639, Type: screening]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
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11
[SID7969543]
 HTS of Estrogen Receptor- alpha Coactivator Binding Potentiators [AID639, Type: screening]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
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12
[SID56436610]
 Inhibition of the MLL-AF4-AF9 Interaction in Pediatric Leukemia Measured in Biochemical System Using Plate Reader - 2160-01_Inhibitor_SinglePoint_HTS_Activity [AID651704, Type: screening]MLLT3 gene product [Homo sapiens] [gi:156104889]
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13
[SID7969543]
 Primary biochemical high-throughput screening assay to measure P97 ATPase inhibition [AID1481, Type: screening]Valosin-containing protein [Homo sapiens] [gi:111305821]
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14
[SID7969543]
 Primary biochemical high-throughput screening assay to measure P97 ATPase inhibition [AID1481, Type: screening]Valosin-containing protein [Homo sapiens] [gi:111305821]
View
15
[SID7969543]
 Primary Cell-based High Throughput Screening assay for inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID525, Type: screening]NR5A1 gene product [Homo sapiens] [gi:20070193]
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16
[SID7969543]
 Primary Cell-based High Throughput Screening assay for inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID525, Type: screening]NR5A1 gene product [Homo sapiens] [gi:20070193]
View
17
[SID7969543]
 Primary Cell-based High Throughput Screening assay for inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID525, Type: screening]NR5A1 gene product [Homo sapiens] [gi:20070193]
View
18
[SID7969543]
 Dose-response cell-based assay for inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID600, Type: confirmatory]NR5A1 gene product [Homo sapiens] [gi:20070193]
View
19
[SID7969543]
 Dose-response cell-based assay for inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID600, Type: confirmatory]NR5A1 gene product [Homo sapiens] [gi:20070193]
View
20
[SID7969543]
 Dose-response cell-based assay for inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID600, Type: confirmatory]NR5A1 gene product [Homo sapiens] [gi:20070193]
View
21
[SID7969543]
 Counterscreen for inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2): Luminescence-based cell-based high throughput assay to identify inverse agonists of the Steroidogenic Factor 1 Nuclear Receptor (SF1; NR5A1) [AID651614, Type: screening]NR5A1 gene product [Homo sapiens] [gi:20070193]
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22
[SID7969543]
 Counterscreen for inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2): Luminescence-based cell-based high throughput assay to identify inverse agonists of the Steroidogenic Factor 1 Nuclear Receptor (SF1; NR5A1) [AID651614, Type: screening]NR5A1 gene product [Homo sapiens] [gi:20070193]
View
23
[SID7969543]
 Counterscreen for inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2): Luminescence-based cell-based high throughput assay to identify inverse agonists of the Steroidogenic Factor 1 Nuclear Receptor (SF1; NR5A1) [AID651614, Type: screening]NR5A1 gene product [Homo sapiens] [gi:20070193]
View
24
[SID7969543]
 Luminescence-based cell-based high throughput confirmation assay for inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2) [AID651613, Type: screening]NR5A2 gene product [Homo sapiens] [gi:4504343]
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25
[SID7969543]
 Luminescence-based cell-based high throughput confirmation assay for inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2) [AID651613, Type: screening]NR5A2 gene product [Homo sapiens] [gi:4504343]
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26
[SID103565235]
IC50 33Inhibition of GAL4-tagged RORalpha by luciferase assay [AID329655, Type: Literature]
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27
[SID103565235]
IC50 33Inhibition of HSV1 GAL4-tagged VP16 by luciferase assay [AID329657, Type: Literature]
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28
[SID56436610]
 Plasma Stability Mouse - Set 2 [AID624419, Type: other]
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29
[SID56436610]
 Plasma Stability Human - 2 [AID624420, Type: other]
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30
[SID56436610]
 Mouse hepatic microsome stability - Set 2 [AID624451, Type: screening]
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31
[SID56436610]
 Human hepatic microsome stability-Set 2 [AID624452, Type: screening]
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32
[SID56436610]
 Early assessment of compound stability in 1x PBS - Set 2 [AID624456, Type: other]
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33
[SID7969543]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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34
[SID7969543]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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35
[SID7969543]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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36
[SID7969543]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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37
[SID7969543]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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38
[SID90341390]
Potency 0.0012Cell Proliferation Assay against a hMSC Cell Line [AID651696, Type: confirmatory]
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39
[SID90341390]
Potency 0.1995qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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40
[SID90341390]
Potency 0.1995qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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41
[SID90341390]
Potency 0.3981qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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42
[SID90341390]
Potency 0.3981qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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43
[SID90341390]
Potency 6.3096Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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44
[SID90341390]
Potency 6.3096Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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45
[SID90341390]
Potency 6.3096Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
View
46
[SID90341390]
Potency 6.3096Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
View
47
[SID7969543]
EC50 12.6138Estrogen Receptor-alpha Coactivator Binding Potentiators Dose Response Confirmation [AID737, Type: confirmatory]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
View
48
[SID7969543]
EC50 12.6138Estrogen Receptor-alpha Coactivator Binding Potentiators Dose Response Confirmation [AID737, Type: confirmatory]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
View
49
[SID7969543]
EC50 12.6138Estrogen Receptor-alpha Coactivator Binding Potentiators Dose Response Confirmation [AID737, Type: confirmatory]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
View
50
[SID7969543]
EC50 12.6138Estrogen Receptor-alpha Coactivator Binding Potentiators Dose Response Confirmation [AID737, Type: confirmatory]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
View