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Mephenesin (CID 4059) - Compound BioActivity Data
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BioActivity Outcomes:
Active(4)
 
 
Inactive(261)
 
 
Inconclusive(30)
 
 
Unspecified(18)
 
 
Top Targets:
NR LBD PPAR(8)
 
 
NR LBD ER(7)
 
 
 
 
NR LBD AR(7)
 
 
NR LBD VDR(5)
 
 
 
NR LBD TR(5)
 
 
BioAssay Types:
Confirmatory(147)
 
 
 
 
Literature(73)
 
 
 
 
Summary(24)
 
 
 
Screening(8)
 
 
BioActivity Types:
Potency(160)
 
 
 
 
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 237    Data Row: 313   Total Pages: 16   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144204909]
Potency-Replicate_1 23.7101qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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2
[SID10321550]
MDR-1 [AID377, Type: other]multidrug resistance protein 1 [Homo sapiens] [gi:42741659]
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3
[SID48416213]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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4
[SID103518989]
Neuroprotective activity in Sprague-Dawley rat DRG neurons assessed as enhancement of neurite outgrowth at 0.01 to 1 uM after 24 hrs by confocal microscopic analysis [AID754208, Type: Literature]
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5
[SID103518989]
Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM [AID977599, Type: Literature]
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6
[SID103518989]
Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM [AID977602, Type: Literature]
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7
[SID8149736]
Assay to identify inhibitors of polyglutamine-induced caspase-3 activation (CASP3) [AID1583, Type: other]
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8
[SID8149736]
Yeast cell-based screen for compounds that suppress polyglutamine aggregation in vivo (75Q-TubU) [AID1593, Type: other]
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9
[SID8149736]
Screen for compounds that correct neuronal dysfunction without cell death as induced by the expression of polyglutamine-expanded, N-terminal huntingtin in C. elegans mechanosensory neurons (HDELENEU) [AID1599, Type: other]
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10
[SID26748509]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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11
[SID8149736]
Screen for compounds that selectively inhibit cytochrome c release from purified mitochondria (CytoCRel) [AID1603, Type: other]
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12
[SID8149736]
Screen for compounds that inhibit polyglutamine induced protein aggregation (AGREG) [AID1604, Type: other]
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13
[SID8149736]
Screening of compounds showing protective effect against cell death induced by familial amyotrophic lateral sclerosis (FALS)-linked mutantsuperoxide dismutase 1 (SOD1) (ALSOD1) [AID1605, Type: other]
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14
[SID8149736]
Screen for compounds that induce the human heat shock transcriptional response (HSEluc) [AID1611, Type: other]
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15
[SID8149736]
Screen for compounds that increase glutamate transport activity in MN-1 cell line (GluUPTAKE) [AID1612, Type: other]
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16
[SID8149736]
Screen for compounds that inhibit protein aggregation formed by mutant SOD1 (GFPSOD1) [AID1613, Type: other]
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17
[SID8149736]
Screen for compounds that reduce polyglutamine (polyQ) inclusions in nerve growth factor (NGF)-treated PC12 cells (GFPQ80) [AID1614, Type: other]
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18
[SID8149736]
Yeast cell-based screen for compounds that suppress polyglutamine aggregation in vivo (75Q-TubH) [AID1616, Type: other]
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19
[SID103518989]
Distribution coefficient, log D at pH 7.4 [AID287367, Type: Literature]
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20
[SID103518989]
Partition coefficient, log P of the compound [AID287368, Type: Literature]
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