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BioActivity Data for Compound Meperidine (CID 4058)

BioActivity Outcomes:
Active(22)
 
 
Inactive(1)
 
 
Inconclusive(7)
 
 
Unspecified(91)
 
 
Top Targets:
7tm 4(18)
 
 
 
p450(7)
 
 
 
ERG2 Sigma1R(5)
 
 
 
CAP ED(2)
 
 
SLC6sbd DAT1(2)
 
 
 
BioAssay Types:
Literature(116)
 
 
 
 
 
BioAssay Categories:
In vitro(2)
 
 
In vivo(17)
 
 
Biochemical(39)
 
 
 
ADME(51)
 
 
 
 
Cell-based(2)
 
 
BioActivity Types:
IC50(9)
 
 
 
EC50(5)
 
 
Ki(4)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 105    Data Row: 121   Total Pages: 7   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103184537]
IC50 0.315Binding affinity against mu-opiate receptor (human) using [3H]DAMGO radioligand [AID152239, Type: Literature]
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2
[SID103184537]
IC50 0.32359Inhibitory concentration against potassium channel HERG [AID243151, Type: Literature]
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3
[SID103184537]
Ki 0.412Displacement of [3H]paroxetine from serotonin transporter (SERT) [AID204538, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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4
[SID103184537]
Ki 0.451Binding affinity against mu opioid receptor was determined in brain membrane preparations from male Hartley guinea-pigs [AID141504, Type: Literature]Mu-type opioid receptor [gi:3024265]
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5
[SID103184537]
IC50 0.5Inhibition of Opioid receptors with [3H]naloxone binding in the absence of NaCl [AID150234, Type: Literature]
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6
[SID103184537]
IC50 0.5Tested for displacement of radioligand [3H]-Naloxone from opiate receptor [AID145928, Type: Literature]
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7
[SID103184537]
EC50 0.7Displacement of radiolabeled dihydromorphine from opioid receptor in rat brain homogenates [AID1123082, Type: Literature]Mu-type opioid receptor [gi:464314]
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8
[SID103184537]
ED50 0.7Displacement of [3H]dihydromorphine from opioid receptor in rat brain homogenate [AID1146144, Type: Literature]Mu-type opioid receptor [gi:464314]
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9
[SID103184537]
ED50 0.7Displacement of [3H]dihydromorphine from opioid receptor in rat brain homogenate [AID1146144, Type: Literature]Sigma non-opioid intracellular receptor 1 [gi:81882051]
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10
[SID103184537]
EC50 0.7Displacement of radiolabeled dihydromorphine from opioid receptor in rat brain homogenates [AID1123082, Type: Literature]Sigma non-opioid intracellular receptor 1 [gi:81882051]
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11
[SID103184537]
EC50 0.7Displacement of radiolabeled dihydromorphine from opioid receptor in rat brain homogenates [AID1123082, Type: Literature]Delta-type opioid receptor [gi:464311]
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12
[SID103184537]
ED50 0.7Displacement of [3H]dihydromorphine from opioid receptor in rat brain homogenate [AID1146144, Type: Literature]Delta-type opioid receptor [gi:464311]
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13
[SID103184537]
ED50 0.7Displacement of [3H]dihydromorphine from opioid receptor in rat brain homogenate [AID1146144, Type: Literature]Kappa-type opioid receptor [gi:464313]
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14
[SID103184537]
EC50 0.7Displacement of radiolabeled dihydromorphine from opioid receptor in rat brain homogenates [AID1123082, Type: Literature]Kappa-type opioid receptor [gi:464313]
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15
[SID103184537]
IC50 2.37Binding affinity against opioid receptor kappa 1 using [3H]- U-69,593 radioligand [AID147859, Type: Literature]
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16
[SID103184537]
EC50 9.4Agonist activity at human cloned mu opioid receptor by [35S]GTPgammaS binding assay [AID392933, Type: Literature]Mu-type opioid receptor [gi:2851402]
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17
[SID103184537]
Ki 17.8Displacement of [3H]WIN-35428 from dopamine transporter (DAT) [AID65195, Type: Literature]Sodium-dependent dopamine transporter [gi:128613]
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18
[SID103184537]
IC50 40Inhibition of Opioid receptors binding by inhibiting specific [3H]naloxone binding by 50% in the presence of 100 mM NaCl [AID150235, Type: Literature]
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19
[SID103184537]
Analgesic activity in dog assessed as increase in response threshold at 16 mg/kg, sc measured 0.5 to 2 hrs post treatment by radiant heat method relative to control [AID1132336, Type: Literature]
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20
[SID85209612]
Ligands of peptide (Class A) GPCRs [AID2063, Type: other]
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