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Memantine (CID 4054) - Compound BioActivity Data
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BioActivity Outcomes:
Active(46)
 
 
Inactive(231)
 
 
Inconclusive(52)
 
 
Unspecified(82)
 
 
Top Targets:
PBP1 iGluR NM..(10)
 
 
 
PBP1 iGluR NM..(9)
 
 
 
NR LBD PPAR(8)
 
 
7tm 4(7)
 
 
NR LBD ER(7)
 
 
BioAssay Types:
Confirmatory(175)
 
 
 
 
Literature(173)
 
 
 
 
 
Summary(24)
 
 
 
Screening(3)
 
 
BioActivity Types:
Potency(188)
 
 
 
 
IC50(31)
 
 
 
 
Ki(7)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 321    Data Row: 411   Total Pages: 21   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103211988]
IC50 0.00095Antagonist activity at recombinant GluN1/GluN2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glycine/glutamate-induced inward current at -70mV by two-electrode voltage clamp assay [AID755470, Type: Literature]Glutamate receptor ionotropic, NMDA 1 [gi:548377]
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2
[SID103211988]
IC50 0.00095Antagonist activity at recombinant GluN1/GluN2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glycine/glutamate-induced inward current at -70mV by two-electrode voltage clamp assay [AID755470, Type: Literature]Glutamate receptor ionotropic, NMDA 2A [gi:14285603]
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3
[SID103211988]
Ki 0.429Displacement of [3H]-(+)-MK-801 from PCP binding site of NMDA receptor in pig brain cortex [AID704017, Type: Literature]
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4
[SID103211988]
Ki 0.54The compound was tested for its ability to block PCP N-methyl-D-aspartate glutamate receptor at the PCP (phencyclidine) binding site in postmortem human frontal cortex. [AID156805, Type: Literature]
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5
[SID103211988]
Ki 0.7Compound with the N-methyl-D-aspartate glutamate receptor blocking activity [AID143463, Type: Literature]
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6
[SID103211988]
IC50 0.718Neuroprotective activity in human SH-SY5Y cells assessed as protection against NMDA-induced cell death after 6 hrs by MTS assay [AID707048, Type: Literature]
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7
[SID103211988]
IC50 0.911Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytes [AID292616, Type: Literature]Glutamate receptor ionotropic, NMDA 2A [gi:14285603]
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8
[SID103211988]
IC50 0.911Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytes [AID292616, Type: Literature]Glutamate receptor ionotropic, NMDA 1 [gi:548377]
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9
[SID103211988]
IC50 1.02Antagonist activity at recombinant NR1/NR2B receptor expressed in Xenopus laevis oocytes [AID292617, Type: Literature]Glutamate receptor ionotropic, NMDA 1 [gi:548377]
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10
[SID103211988]
IC50 1.02Antagonist activity at recombinant NR1/NR2B receptor expressed in Xenopus laevis oocytes [AID292617, Type: Literature]Glutamate receptor ionotropic, NMDA 2B [gi:14548162]
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11
[SID103211988]
Ki 1.16Displacement of [3H]MK-801 from NMDAR in Sprague-Dawley rat cerebral cortex homogenates after 2 hrs by liquid scintillation counting [AID707053, Type: Literature]
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12
[SID103211988]
Ki 1.2Displacement of [3H]-(+)-MK-801 from NMDA receptor phencyclidine binding site in guinea pig brain cortex homogenates after 5 mins by scintillation counting [AID536042, Type: Literature]
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13
[SID103211988]
Ki 1.2Displacement of [3H]-(+)-MK801 from PCP binding site of NMDA receptor from pig brain cortex after 150 mins by scintillation counting [AID488105, Type: Literature]
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14
[SID103211988]
IC50 1.5Antagonist activity at NMDA receptor in rat cerebellar granule neurons assessed as inhibition of NMDA-induced increase in intracellular calcium level by fluorometric assay [AID456467, Type: Literature]
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15
[SID103211988]
IC50 1.5Antagonist activity against NMDA receptor in rat cerebellar granule neurons assessed as inhibition of NMDA -induced increase in intracellular calcium level by Fura-2 AM dye based fluorimetry [AID416368, Type: Literature]
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16
[SID103211988]
IC50 1.5Inhibition of NMDA receptor in rat cerebellar granule neurons assessed as NMDA-induced intracellular calcium increase [AID410126, Type: Literature]
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17
[SID103211988]
IC50 1.5Antagonist activity at NMDA receptor in cerebellar granule neurons assessed as inhibition of NMDA-induced increase in intracellular calcium concentration by fluorometric assay [AID388528, Type: Literature]
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18
[SID103211988]
IC50 1.5Antagonist activity at NMDAR in rat cerebellar granule neurons assessed as inhibition of NMDA-induced calcium flux after 5 mins using FURA-2AM in presence of glycine [AID637740, Type: Literature]
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19
[SID103211988]
IC50 3.05Antagonist activity at NMDA receptor in ICR mouse synaptoneurosome assessed as inhibition of NMDA/Gly-mediated 45-calcium influx [AID305668, Type: Literature]
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20
[SID103211988]
IC50 5.5Inhibition of dexamethasone-induced human NR1-1a/NR2B receptor-mediated excitotoxicity in (S)-glutamate/glycine-stimulated mouse L13-E6 cells assessed as LDH release after 30 mins [AID480455, Type: Literature]Glutamate receptor ionotropic, NMDA 2B [gi:14548162]
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