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Memantine (CID 4054) - Compound BioActivity Data
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BioActivity Outcomes:
Active(41)
 
 
Inactive(228)
 
 
Inconclusive(53)
 
 
Unspecified(72)
 
 
Top Targets:
PBP1 iGluR NM..(9)
 
 
 
PBP1 iGluR NM..(8)
 
 
 
NR LBD PPAR(8)
 
 
NR LBD AR(7)
 
 
 
NR LBD ER(7)
 
 
BioAssay Types:
Confirmatory(172)
 
 
 
 
Literature(158)
 
 
 
 
 
Summary(24)
 
 
 
Screening(3)
 
 
BioActivity Types:
Potency(186)
 
 
 
 
IC50(28)
 
 
 
 
Ki(7)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 306    Data Row: 394   Total Pages: 8   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103211988]
Ki 0.429Displacement of [3H]-(+)-MK-801 from PCP binding site of NMDA receptor in pig brain cortex [AID704017, Type: Literature]
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2
[SID103211988]
Ki 0.54The compound was tested for its ability to block PCP N-methyl-D-aspartate glutamate receptor at the PCP (phencyclidine) binding site in postmortem human frontal cortex. [AID156805, Type: Literature]
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3
[SID103211988]
Ki 0.7Compound with the N-methyl-D-aspartate glutamate receptor blocking activity [AID143463, Type: Literature]
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4
[SID103211988]
IC50 0.718Neuroprotective activity in human SH-SY5Y cells assessed as protection against NMDA-induced cell death after 6 hrs by MTS assay [AID707048, Type: Literature]
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5
[SID103211988]
IC50 0.911Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytes [AID292616, Type: Literature]Glutamate receptor ionotropic, NMDA 1 [gi:548377]
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6
[SID103211988]
IC50 0.911Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytes [AID292616, Type: Literature]Glutamate receptor ionotropic, NMDA 2A [gi:14285603]
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7
[SID103211988]
IC50 1.02Antagonist activity at recombinant NR1/NR2B receptor expressed in Xenopus laevis oocytes [AID292617, Type: Literature]Glutamate receptor ionotropic, NMDA 1 [gi:548377]
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8
[SID103211988]
IC50 1.02Antagonist activity at recombinant NR1/NR2B receptor expressed in Xenopus laevis oocytes [AID292617, Type: Literature]Glutamate receptor ionotropic, NMDA 2B [gi:14548162]
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9
[SID103211988]
Ki 1.16Displacement of [3H]MK-801 from NMDAR in Sprague-Dawley rat cerebral cortex homogenates after 2 hrs by liquid scintillation counting [AID707053, Type: Literature]
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10
[SID103211988]
Ki 1.2Displacement of [3H]-(+)-MK801 from PCP binding site of NMDA receptor from pig brain cortex after 150 mins by scintillation counting [AID488105, Type: Literature]
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11
[SID103211988]
Ki 1.2Displacement of [3H]-(+)-MK-801 from NMDA receptor phencyclidine binding site in guinea pig brain cortex homogenates after 5 mins by scintillation counting [AID536042, Type: Literature]
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12
[SID103211988]
IC50 1.5Antagonist activity at NMDA receptor in rat cerebellar granule neurons assessed as inhibition of NMDA-induced increase in intracellular calcium level by fluorometric assay [AID456467, Type: Literature]
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13
[SID103211988]
IC50 1.5Antagonist activity at NMDAR in rat cerebellar granule neurons assessed as inhibition of NMDA-induced calcium flux after 5 mins using FURA-2AM in presence of glycine [AID637740, Type: Literature]
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14
[SID103211988]
IC50 1.5Antagonist activity at NMDA receptor in cerebellar granule neurons assessed as inhibition of NMDA-induced increase in intracellular calcium concentration by fluorometric assay [AID388528, Type: Literature]
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15
[SID103211988]
IC50 1.5Inhibition of NMDA receptor in rat cerebellar granule neurons assessed as NMDA-induced intracellular calcium increase [AID410126, Type: Literature]
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16
[SID103211988]
IC50 1.5Antagonist activity against NMDA receptor in rat cerebellar granule neurons assessed as inhibition of NMDA -induced increase in intracellular calcium level by Fura-2 AM dye based fluorimetry [AID416368, Type: Literature]
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17
[SID103211988]
IC50 3.05Antagonist activity at NMDA receptor in ICR mouse synaptoneurosome assessed as inhibition of NMDA/Gly-mediated 45-calcium influx [AID305668, Type: Literature]
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18
[SID103211988]
IC50 5.5Inhibition of dexamethasone-induced human NR1-1a/NR2B receptor-mediated excitotoxicity in (S)-glutamate/glycine-stimulated mouse L13-E6 cells assessed as LDH release after 30 mins [AID480455, Type: Literature]Glutamate receptor ionotropic, NMDA 1 [gi:548377]
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19
[SID103211988]
IC50 5.5Inhibition of dexamethasone-induced human NR1-1a/NR2B receptor-mediated excitotoxicity in (S)-glutamate/glycine-stimulated mouse L13-E6 cells assessed as LDH release after 30 mins [AID480455, Type: Literature]Glutamate receptor ionotropic, NMDA 2B [gi:14548162]
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20
[SID103211988]
IC50 5.6Inhibition of dexamethasone-induced human NR1-1a/NR2A receptor-mediated excitotoxicity in (S)-glutamate/glycine-stimulated mouse L12-G10 cells assessed as LDH release after 30 mins [AID480453, Type: Literature]Glutamate receptor ionotropic, NMDA 2A [gi:14285603]
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21
[SID103211988]
IC50 5.6Inhibition of dexamethasone-induced human NR1-1a/NR2A receptor-mediated excitotoxicity in (S)-glutamate/glycine-stimulated mouse L12-G10 cells assessed as LDH release after 30 mins [AID480453, Type: Literature]Glutamate receptor ionotropic, NMDA 1 [gi:548377]
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22
[SID104171191]
Potency 6.7456Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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23
[SID103211988]
IC50 9.52Inhibition of NMDA NR1/NR2B receptor expressed in xenopus oocytes assessed as inhibition of NMDA and glycine-induced current response by two-electrode voltage clamp assay [AID341425, Type: Literature]
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24
[SID103211988]
IC50 13.75Antitrypanosomal activity against bloodstream form of Trypanosoma brucei 427 after 48 hrs by hemocytometer analysis [AID637741, Type: Literature]
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25
[SID103211988]
IC50 13.75Trypanocidal activity against Trypanosoma brucei 427 bloodstream form assessed as decrease in cell density after 48 hrs by hemocytometry [AID456470, Type: Literature]
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26
[SID144203750]
Potency-Replicate_1 26.6032qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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27
[SID103211988]
IC50 27.2Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy [AID386625, Type: Literature]Solute carrier family 22 member 1 [gi:313104181]
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28
[SID144203750]
Potency-Replicate_1 29.8493qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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29
[SID144203750]
Potency-Replicate_1 29.8493qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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30
[SID144203750]
Potency-Replicate_1 29.8493qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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31
[SID144203750]
Potency-Replicate_1 29.8493qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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32
[SID144203750]
Potency 35.4813qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID720533, Type: confirmatory]
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33
[SID103211988]
Inhibition of imidazole receptor 2 in mouse hippocampal neurons assessed as reduction in tPA-induced Erk1/2 activation at 30 uM pre-incubated for 4 hrs before tPA stimulation by ELISA [AID710418, Type: Literature]
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34
[SID103211988]
Neuroprotective activity against Abeta-induced neuronal apoptosis in mouse hippocampal neurons assessed as reduction in total neuronal nuclei level at 30 uM pre-incubated for 4 hrs before Abeta challenge for 72 hrs by immunofluorescence microscopy [AID710415, Type: Literature]
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35
[SID103211988]
Neuroprotective activity against Abeta-induced neuronal apoptosis in mouse hippocampal neurons assessed as reduction in DNA fragmentation at 30 uM pre-incubated for 4 hrs before Abeta challenge for 72 hrs by immunofluorescence microscopy [AID710416, Type: Literature]
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36
[SID26751885]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_19, Type: Literature]
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37
[SID26751885]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_26, Type: Literature]
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38
[SID26751885]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_39, Type: Literature]
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39
[SID103211988]
Inhibition of dexamethasone-induced human NR1-1a/NR2A receptor-mediated excitotoxicity in (S)-glutamate/glycine-stimulated mouse L12-G10 cells assessed as LDH release at 20 uM after 30 mins [AID480458, Type: Literature]Glutamate receptor ionotropic, NMDA 1 [gi:548377]
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40
[SID26751885]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_54, Type: Literature]
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41
[SID103211988]
Inhibition of dexamethasone-induced human NR1-1a/NR2A receptor-mediated excitotoxicity in (S)-glutamate/glycine-stimulated mouse L12-G10 cells assessed as LDH release at 20 uM after 30 mins [AID480458, Type: Literature]Glutamate receptor ionotropic, NMDA 2A [gi:14285603]
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42
[SID103211988]
IC50 10Inhibition of electric eel AChE by modified Ellman's method [AID480448, Type: Literature]Acetylcholinesterase [gi:14916521]
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43
[SID103211988]
IC50 10Inhibition of equine serum BChE by modified Ellman's method [AID480449, Type: Literature]Cholinesterase [gi:21362409]
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44
[SID103211988]
Km 34TP_TRANSPORTER: uptake (electrogenesis) in Xenopus laevis oocytes [AID679500, Type: other]Solute carrier family 22 member 2 [gi:313104182]
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45
[SID103211988]
IC50 55Antagonist activity against glutamate receptor in rat cerebellar granule neurons assessed as inhibition of glutamate-induced increase in intracellular calcium level by Fura-2 AM dye based fluorimetry [AID416367, Type: Literature]
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46
[SID103211988]
IC50 55Antagonist activity at NMDA receptor in cerebellar granule neurons assessed as inhibition of glutamate-induced increase in intracellular calcium concentration by fluorometric assay [AID388526, Type: Literature]
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47
[SID103211988]
IC50 55Antagonist activity at NMDA receptor in rat cerebellar granule neurons assessed as inhibition of glutamate-induced increase in intracellular calcium level by fluorometric assay [AID456466, Type: Literature]
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48
[SID103211988]
IC50 55Antagonist activity at NMDAR in rat cerebellar granule neurons assessed as inhibition of glutamate-induced calcium flux after 5 mins using FURA-2AM in presence of glycine [AID637739, Type: Literature]
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49
[SID103211988]
IC50 55.4Inhibition of NMDA receptor in rat cerebellar granule neurons assessed as glutamate-induced intracellular calcium increase [AID410125, Type: Literature]
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50
[SID103211988]
Ki 100Displacement of [3H]Ifenprodil from NMDAR-2B in Sprague-Dawley rat frontal cortex homogenates after 2 hrs by liquid scintillation counting [AID707052, Type: Literature]Glutamate receptor ionotropic, NMDA 2B [gi:548372]
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