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Quisqualic Acid (CID 40539) - Compound BioActivity Data
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BioActivity Outcomes:
Active(51)
 
 
Inactive(716)
 
 
Inconclusive(27)
 
 
Unspecified(39)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
 
7TM GPCR Srsx(12)
 
 
PLDc mTdp1 2(9)
 
 
 
PBPb(9)
 
 
p450(9)
 
 
 
BioAssay Types:
Confirmatory(366)
 
 
 
 
 
Screening(358)
 
 
Literature(96)
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(326)
 
 
 
 
 
IC50(44)
 
 
 
 
EC50(23)
 
 
 
 
Ki(12)
 
 
 
Kd(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 667    Data Row: 833   Total Pages: 42   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103195075]
Ki 0.01Inhibition of binding to rat mGluR1a (metabotropic glutamate receptor) expressed in HEK-293 cells [AID108493, Type: Literature]Metabotropic glutamate receptor 1 [gi:121300]
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2
[SID46392526]
IC50 0.02Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB [AID977608, Type: Literature]Chain A, Crystal Structure Of The Glur2 Ligand Binding Core (s1s2j) In Complex With Quisqualate In A Non Zinc Crystal Form At 2.15 Angstroms Resolution [gi:28373741]
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3
[SID46392526]
IC50 0.02Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB [AID977608, Type: Literature]Chain A, Crystal Structure Of The Glur2 Ligand Binding Core (s1s2j) In Complex With Quisqualate In A Non Zinc Crystal Form At 2.15 Angstroms Resolution [gi:28373741]
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4
[SID46392527]
IC50 0.02Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB [AID977608, Type: Literature]Chain A, Crystal Structure Of The Glur2 Ligand Binding Core (S1s2j) In Complex With Quisqualate In A Zinc Crystal Form At 1.65 Angstroms Resolution [gi:28373743]
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5
[SID46392527]
IC50 0.02Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB [AID977608, Type: Literature]Chain A, Crystal Structure Of The Glur2 Ligand Binding Core (S1s2j) In Complex With Quisqualate In A Zinc Crystal Form At 1.65 Angstroms Resolution [gi:28373743]
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6
[SID103195075]
IC50 0.025In vitro binding affinity against Metabotropic glutamate receptor using [3H](S)-glutamic acid [AID108343, Type: Literature]
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7
[SID103195075]
IC50 0.04sensitization of CA1 pyramidal neurons to depolarizations by L-AP6 after exposure to quisqualic acid [AID42544, Type: Literature]
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8
[SID103195075]
Ki 0.055Agonist potency against cloned metabotropic glutamate receptor 5 [AID107059, Type: Literature]
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9
[SID103195075]
IC50 0.08Compound was tested for in vitro binding affinity against Ionotropic glutamate receptor AMPA using [3H]AMPA ligand [AID92048, Type: Literature]
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10
[SID103195075]
EC50 0.1Effective concentration by measuring IP1 accumulation using rat fore brain synaptoneurosomes [AID175679, Type: Literature]
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11
[SID103195075]
Ki 0.134Displacement of [3H]SYM2081 from rat recombinant iGluR6 [AID339928, Type: Literature]Glutamate receptor ionotropic, kainate 2 [gi:3287965]
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12
[SID103195075]
IC50 0.15Compound was tested or its affinity against ionotropic glutamate receptor ionotropic kainate in rats [AID93711, Type: Literature]
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13
[SID103195075]
EC50 0.15Concentration for half maximal activation of metabotropic glutamate mGluR5a in human [AID109493, Type: Literature]
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14
[SID103195075]
Ki 0.171Displacement of [3H]SYM2081 from rat recombinant iGluR5 [AID339927, Type: Literature]Glutamate receptor ionotropic, kainate 1 [gi:1169962]
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15
[SID103195075]
EC50 0.2Concentration for half maximal activation of metabotropic glutamate mGluR5b in rat [AID107064, Type: Literature]
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16
[SID103195075]
EC50 0.2Concentration for half maximal activation of metabotropic glutamate mGluR1a in rat [AID108498, Type: Literature]
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17
[SID103195075]
EC50 0.2Effective concentration for half maximal stimulation of PI hydrolysis (mGluR1a) [AID108648, Type: Literature]
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18
[SID103195075]
EC50 0.3Concentration for half maximal activation of metabotropic glutamate mGluR5a in rat [AID107063, Type: Literature]
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19
[SID103195075]
EC50 0.32Effective concentration by measuring IP2 accumulation using rat fore brain synaptoneurosomes [AID175680, Type: Literature]
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20
[SID103195075]
IC50 0.48Inhibition of specific brain peptidase [AID156919, Type: Literature]
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