Mefloquine (CID 4046) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(246)
 
 
Inactive(90)
 
 
Inconclusive(34)
 
 
Unspecified(320)
 
 
Top Targets:
P53(3)
 
 
HELICc(2)
 
 
PLN02808(2)
 
 
Peptidase C1A(2)
 
 
STKc ERK1 2 l..(2)
 
 
BioAssay Types:
Literature(499)
 
 
 
 
 
Confirmatory(61)
 
 
 
 
Screening(22)
 
 
 
BioActivity Types:
IC50(203)
 
 
 
 
 
Potency(58)
 
 
 
 
EC50(10)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 690    Data Row: 690   Total Pages: 14   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103210741]
IC50 0.00031Intrinsic equimolar activity against Plasmodium falciparum D6 (Sierra Leone) relative to QHS [AID158862, Type: Literature]
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2
[SID103210741]
IC50 0.0007Antimalarial activity against Plasmodium falciparum W2 in MSF assay [AID316377, Type: Literature]
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3
[SID103210741]
IC50 0.00111Intrinsic equimolar activity against Plasmodium falciparum W2 Indochina relative to QHS [AID158863, Type: Literature]
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4
[SID103210741]
IC50 0.002Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum PFB Brazil by [3H]hypoxanthine uptake [AID358507, Type: Literature]
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5
[SID103210741]
IC50 0.0021Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by flow-cytometry [AID479487, Type: Literature]
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6
[SID103210741]
IC50 0.0021Antiplasmodial activity against Plasmodium falciparum 3D7 infected in RBCs by firefly luciferase reporter gene assay [AID576507, Type: Literature]
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7
[SID103210741]
IC50 0.00233Antimalarial activity against chloroquine-resistant, mefloquine-sensitive Plasmodium falciparum RCS [AID343938, Type: Literature]
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8
[SID103210741]
IC50 0.00309Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum W2 [AID343941, Type: Literature]
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9
[SID103210741]
IC50 0.00309Antimalarial activity against Plasmodium falciparum W2 [AID298579, Type: Literature]
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10
[SID103210741]
IC50 0.0032Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes after 48 hrs by flow-cytometry [AID479488, Type: Literature]
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11
[SID103210741]
IC50 0.0046Antimicrobial activity against Plasmodium falciparum trophozoites by microscopy treated during ring stage [AID519192, Type: Literature]
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12
[SID103210741]
IC50 0.0048Antimalarial activity against Plasmodium falciparum W2 after 24 hrs by [3H]hypoxanthine uptake [AID334266, Type: Literature]
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13
[SID103210741]
IC50 0.00485Antiparasitic activity against chloroquine-sensitive Plasmodium falciparum by [3H]hypoxanthine incorporation [AID317969, Type: Literature]
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14
[SID103210741]
IC50 0.00489Antimalarial activity against Plasmodium falciparum W2 [AID318613, Type: Literature]
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15
[SID103210741]
IC50 0.0049Antimalarial activity against Plasmodium falciparum at the ring stage infected in human erythrocytes assessed as growth inhibition by microscopic analysis using giemsa staining [AID576571, Type: Literature]
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16
[SID103210741]
IC50 0.0049Antimalarial activity against Plasmodium falciparum infected in human erythrocytes assessed as growth inhibition by microscopic analysis using giemsa staining [AID576575, Type: Literature]
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17
[SID103210741]
IC50 0.00493Antimalarial activity against Plasmodium falciparum W2 [AID595215, Type: Literature]
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18
[SID103210741]
IC50 0.00496Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 [AID361515, Type: Literature]
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19
[SID103210741]
IC50 0.005Antimalarial activity against Plasmodium falciparum FCR3 [AID607063, Type: Literature]
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20
[SID103210741]
IC50 0.00502In vitro inhibitory activity against chloroquine-resistant Plasmodium falciparum W2 Indochina [AID159766, Type: Literature]
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21
[SID103210741]
IC50 0.00535Antimalarial activity against chloroquine-resistant, mefloquine-susceptible Plasmodium falciparum W2 [AID390618, Type: Literature]
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22
[SID103210741]
IC50 0.00575Inhibitory concentration against Plasmodium falciparum W2 Indochina [AID158856, Type: Literature]
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23
[SID103210741]
IC50 0.0059Antimalarial activity against Plasmodium falciparum W2 by hypoxanthine uptake [AID404449, Type: Literature]
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24
[SID103210741]
IC50 0.0059Antimalarial activity against Plasmodium falciparum D6 in MSF assay [AID316376, Type: Literature]
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25
[SID103210741]
IC50 0.0059Antimalarial activity against drug-resistant Plasmodium falciparum W2 [AID544091, Type: Literature]
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26
[SID103210741]
IC50 0.00601Antimalarial activity against chloroquine-resistant, mefloquine-sensitive Plasmodium falciparum W2 assessed as inhibition of [3H]hypoxanthine uptake [AID549609, Type: Literature]
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27
[SID103210741]
IC50 0.0063Antimalarial activity against Plasmodium falciparum assessed as parasites growth inhibition using giemsa staining after 24 to 56 hrs by microscopic analysis in presence of 10% human serum [AID586611, Type: Literature]
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28
[SID103210741]
IC50 0.00639Antimicrobial activity against Plasmodium vivax at the ring stage by microscopy [AID519193, Type: Literature]
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29
[SID103210741]
IC50 0.0064Antimicrobial activity against Plasmodium falciparum at the ring stage by microscopy [AID519191, Type: Literature]
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30
[SID103210741]
IC50 0.0064Antimalarial activity against ring stage of Plasmodium falciparum assessed as parasites growth inhibition using giemsa staining after 24 to 56 hrs by microscopic analysis in presence of 10% human serum [AID586609, Type: Literature]
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31
[SID103210741]
IC50 0.0067Antimalarial activity against NITD609-resistant Plasmodium falciparum Dd2 Clone1 bearing P-type ATPase4 I398F and P990R mutations after 72 hrs by SYBR green based fluorescence assay [AID510927, Type: Literature]
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32
[SID103210741]
IC50 0.0067Antimalarial activity against Plasmodium falciparum assessed as parasite growth inhibition after 48 hrs by [3H]hypoxanthin incorporation assay [AID563687, Type: Literature]
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33
[SID103210741]
IC50 0.0069In vitro sensitivity for Plasmodium falciparum FcB1R [AID159746, Type: Literature]
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34
[SID103210741]
IC50 0.007Antimalarial activity against NITD609-resistant Plasmodium falciparum Dd2 Clone2 bearing P-type ATPase4 T418N and P990R mutations after 72 hrs by SYBR green based fluorescence assay [AID510928, Type: Literature]
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35
[SID103210741]
IC50 0.0072Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as [3H]hypoxanthine incorporation [AID554566, Type: Literature]
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36
[SID103210741]
IC50 0.00726Antimicrobial activity against Plasmodium vivax at the ring stage measured after 30 hrs by microscopy [AID519196, Type: Literature]
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37
[SID103210741]
IC50 0.00727Antimicrobial activity against Plasmodium vivax trophozoites measured after 30 hrs by microscopy [AID519195, Type: Literature]
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38
[SID103210741]
IC50 0.00734Antimalarial activity against Plasmodium falciparum D6 [AID318612, Type: Literature]
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39
[SID103210741]
IC50 0.0077Antimalarial activity against Plasmodium vivax assessed as parasites growth inhibition using giemsa staining after 24 to 56 hrs by microscopic analysis in presence of 20% human serum [AID586610, Type: Literature]
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40
[SID103210741]
IC50 0.00778Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected human erythrocytes as [3H]hypoxanthine uptake after 24 hrs [AID377947, Type: Literature]
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41
[SID103210741]
IC50 0.0079Antimalarial activity against Plasmodium vivax at the ring stage infected in human erythrocytes assessed as growth inhibition by microscopic analysis using giemsa staining [AID576573, Type: Literature]
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42
[SID103210741]
IC50 0.008Antimalarial activity against Plasmodium vivax with >50% parasites at ring stage infected in human erythrocytes assessed as growth inhibition after 30 to 50 hrs by microscopic analysis using giemsa staining [AID576577, Type: Literature]
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43
[SID103210741]
IC50 0.008Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as inhibition of [3H]hypoxanthine incorporation [AID586613, Type: Literature]
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44
[SID103210741]
IC50 0.008Antimalarial activity against Plasmodium falciparum K1 [AID607065, Type: Literature]
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45
[SID103210741]
IC50 0.008Antimalarial activity against Plasmodium falciparum W2 infected in human erythrocytes assessed as decrease in parasitemia after 72 hrs [AID605733, Type: Literature]
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46
[SID103210741]
IC50 0.008Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 after 48 hrs by lactate dehydrogenase assay [AID636076, Type: Literature]
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47
[SID103210741]
IC50 0.008Antimalarial activity against NITD609-resistant Plasmodium falciparum Dd2 Clone3 bearing P-type ATPase4 D1247Y mutations after 72 hrs by SYBR green based fluorescence assay [AID510929, Type: Literature]
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48
[SID103210741]
IC50 0.008Antimalarial activity against Plasmodium falciparum assessed as [35S]Met/Cys incorporation by SYBR green based fluorescence assay [AID510939, Type: Literature]
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49
[SID103210741]
IC50 0.008Inhibitory concentration against Plasmodium falciparum W2 infected erythrocytes [AID158037, Type: Literature]
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50
[SID103210741]
IC50 0.008Inhibition of Plasmodium falciparum FCM29 [AID159738, Type: Literature]
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