MLS002702493 (CID 404472) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(94)
 
 
Inactive(183)
 
 
Inconclusive(12)
 
 
Unspecified(7)
 
 
Top Targets:
7TM GPCR Srx(11)
 
 
 
 
7TM GPCR Srsx(4)
 
 
 
PDI a PDI a&a..(4)
 
 
 
TIR 2(3)
 
 
Beta-lactamas..(3)
 
 
 
BioAssay Types:
Screening(151)
 
 
 
Confirmatory(139)
 
 
 
 
 
Literature(3)
 
 
BioActivity Types:
Potency(55)
 
 
 
 
 
IC50(21)
 
 
 
 
 
AC50(3)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 286    Data Row: 296   Total Pages: 6   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID92764461]
IC50 0.14851Luminescence-based cell-based high throughput dose response assay for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) [AID624394, Type: confirmatory]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
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2
[SID92764461]
IC50 0.14851Luminescence-based cell-based high throughput dose response assay for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) [AID624394, Type: confirmatory]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
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3
[SID92764461]
IC50 0.14851Luminescence-based cell-based high throughput dose response assay for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) [AID624394, Type: confirmatory]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
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4
[SID92764461]
Potency 0.3663qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]
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5
[SID92764461]
Potency 0.4109qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]
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6
[SID92764461]
Potency 0.5623qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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7
[SID92764461]
Potency 0.5623qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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8
[SID92764461]
IC50 0.59744Counterscreen for inhibitors of TLR9-MyD88 binding: Luminescence-based cell-based high throughput dose response assay to identify cytotoxic compounds using TLR9-MyD88 CHO cells [AID588339, Type: confirmatory]
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9
[SID92764461]
Potency 0.7308A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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10
[SID92764461]
IC50 0.84497Counterscreen for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3):Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) [AID624395, Type: confirmatory]transactivating tegument protein VP16 [Human herpesvirus 1] [gi:9629429]
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11
[SID92764461]
Potency 0.92A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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12
[SID92764461]
Potency 1.2995qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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13
[SID92764461]
AC50 1.69Cytotoxicity (24 hours) Measured in Cell-Based System Using Plate Reader - 2137-02_Inhibitor_Dose_CherryPick_Activity [AID624285, Type: confirmatory]Prolyl 4-hydroxylase, beta polypeptide [Homo sapiens] [gi:14790033]
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14
[SID92764461]
AC50 1.69Cytotoxicity (24 hours) Measured in Cell-Based System Using Plate Reader - 2137-02_Inhibitor_Dose_CherryPick_Activity [AID624285, Type: confirmatory]Prolyl 4-hydroxylase, beta polypeptide [Homo sapiens] [gi:14790033]
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15
[SID92764461]
Potency 2.5119qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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16
[SID92764461]
Potency 2.8184qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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17
[SID92764461]
Potency 2.8184qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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18
[SID92764461]
Potency 3.9811qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ATXN2 gene product [Homo sapiens] [gi:171543895]
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19
[SID92764461]
Potency 3.9811qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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20
[SID92764461]
Potency 4.4668qHTS of GLP-1 Receptor Inverse Agonists: Cytotox Screen [AID624418, Type: confirmatory]
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21
[SID92764461]
Potency 5.1735qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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22
[SID92764461]
IC50 5.777Fluorescence-based cell-based high throughput dose response assay for inhibitors of TLR9-MyD88 binding [AID588340, Type: confirmatory]toll-like receptor 9 [Homo sapiens] [gi:194068499]
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23
[SID92764461]
IC50 5.777Fluorescence-based cell-based high throughput dose response assay for inhibitors of TLR9-MyD88 binding [AID588340, Type: confirmatory]toll-like receptor 9 [Homo sapiens] [gi:194068499]
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24
[SID92764461]
Potency 11.2202qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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25
[SID92764461]
 uHTS determination of small molecule cytotoxicity in a fluorescence assay to identify cystic fibrosis induced NFkb Inhibitors [AID602141, Type: screening]
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26
[SID92764461]
 Counterscreen for biased ligands (antagonists) of the melanocortin 4 receptor (MC4R): TRFRET-based cell-based high throughput assay to identify nonselective inhibitors of cAMP signaling [AID602193, Type: screening]
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27
[SID535694]
 NCI human tumor cell line growth inhibition assay. Data for the NCI-H226 Non-Small Cell Lung cell line [AID3, Type: confirmatory]
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28
[SID535694]
 NCI human tumor cell line growth inhibition assay. Data for the OVCAR-4 Ovarian cell line [AID105, Type: confirmatory]
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29
[SID535694]
 NCI human tumor cell line growth inhibition assay. Data for the OVCAR-5 Ovarian cell line [AID107, Type: confirmatory]
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30
[SID535694]
 NCI human tumor cell line growth inhibition assay. Data for the OVCAR-8 Ovarian cell line [AID109, Type: confirmatory]
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31
[SID535694]
 NCI human tumor cell line growth inhibition assay. Data for the RPMI-8226 Leukemia cell line [AID113, Type: confirmatory]
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32
[SID535694]
 NCI human tumor cell line growth inhibition assay. Data for the SR Leukemia cell line [AID115, Type: confirmatory]
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33
[SID535694]
 NCI human tumor cell line growth inhibition assay. Data for the CCRF-CEM Leukemia cell line [AID119, Type: confirmatory]
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34
[SID535694]
 NCI human tumor cell line growth inhibition assay. Data for the K-562 Leukemia cell line [AID121, Type: confirmatory]
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35
[SID535694]
 NCI human tumor cell line growth inhibition assay. Data for the MOLT-4 Leukemia cell line [AID123, Type: confirmatory]
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36
[SID535694]
 NCI human tumor cell line growth inhibition assay. Data for the CAKI-1 Renal cell line [AID131, Type: confirmatory]
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37
[SID535694]
 NCI human tumor cell line growth inhibition assay. Data for the RXF 393 Renal cell line [AID133, Type: confirmatory]
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38
[SID535694]
 NCI human tumor cell line growth inhibition assay. Data for the 786-0 Renal cell line [AID137, Type: confirmatory]
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39
[SID535694]
 NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line [AID139, Type: confirmatory]
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40
[SID535694]
 NCI human tumor cell line growth inhibition assay. Data for the TK-10 Renal cell line [AID141, Type: confirmatory]
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41
[SID535694]
 NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line [AID143, Type: confirmatory]
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42
[SID535694]
 NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line [AID145, Type: confirmatory]
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43
[SID535694]
 NCI human tumor cell line growth inhibition assay. Data for the T-47D Breast cell line [AID91, Type: confirmatory]
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44
[SID535694]
 NCI human tumor cell line growth inhibition assay. Data for the NCI/ADR-RES Breast cell line [AID93, Type: confirmatory]
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45
[SID535694]
 NCI human tumor cell line growth inhibition assay. Data for the LOX IMVI Melanoma cell line [AID23, Type: confirmatory]
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46
[SID535694]
 NCI human tumor cell line growth inhibition assay. Data for the M14 Melanoma cell line [AID25, Type: confirmatory]
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47
[SID535694]
 NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line [AID13, Type: confirmatory]
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48
[SID535694]
 NCI human tumor cell line growth inhibition assay. Data for the NCI-H522 Non-Small Cell Lung cell line [AID15, Type: confirmatory]
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49
[SID535694]
 NCI human tumor cell line growth inhibition assay. Data for the SF-268 Central Nervous System cell line [AID45, Type: confirmatory]
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50
[SID535694]
 NCI human tumor cell line growth inhibition assay. Data for the HT29 Colon cell line [AID65, Type: confirmatory]
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