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Mechlorethamine (CID 4033) - Compound BioActivity Data
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BioActivity Outcomes:
Active(17)
 
 
Inactive(68)
 
 
Inconclusive(44)
 
 
Unspecified(40)
 
 
Top Targets:
NAD binding 8(5)
 
 
PLDc mTdp1 2(3)
 
 
 
NR LBD TR(2)
 
 
Peptidase C1A(2)
 
 
ANK(2)
 
 
BioAssay Types:
Literature(63)
 
 
 
 
 
Confirmatory(54)
 
 
 
Screening(4)
 
 
BioActivity Types:
Potency(51)
 
 
 
IC50(26)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 164    Data Row: 169   Total Pages: 4   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103165035]
IC50 0.029Ability to reduce cell density of UV4 cells to 50% after 4 hr of exposure to air [AID215463, Type: Literature]
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2
[SID103165035]
IC50 0.15Ability to reduce cell density of EMT6 cells to 50% after 4 hr of exposure to air [AID67761, Type: Literature]
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3
[SID103165035]
IC50 1.09Ability to reduce cell density of SKOV3 cells to 50% after 4 hr of exposure to air [AID205119, Type: Literature]
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4
[SID103165035]
IC50 2Cytotoxicity against AA8 cell and IC50 values were determined as drug concentration required to inhibit cell protein to 50%. [AID9488, Type: Literature]
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5
[SID103165035]
IC50 2.2Concentration for 50% inhibition of AA8 cells growth under aerobic conditions after 18 hours exposure [AID9681, Type: Literature]
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6
[SID103165035]
IC50 2.5Ability to reduce cell density of AA8 cells to 50% after 4 hr of exposure to air [AID9678, Type: Literature]
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7
[SID103165035]
IC50 7.6Growth inhibition of human DU145 cells after 3 days by SRB assay [AID288401, Type: Literature]
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8
[SID103165035]
IC50 7.6Induction of cell cycle arrest in human DU145 cells assessed as accumulation at mid-S phase at 10 uM after 24 hrs by flow cytometry [AID288406, Type: Literature]
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9
[SID103165035]
Ability to reduce surviving fraction of EMT6 cells to 10% when exposed to N2 for 3 hrs [AID67630, Type: Literature]
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10
[SID103165035]
Ability to reduce surviving fraction of EMT6 cells to 10% when exposed to air for 3 hrs [AID67631, Type: Literature]
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11
[SID103165035]
Hypoxic cytotoxicity ratio was determined [AID67632, Type: Literature]
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12
[SID48414146]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary SingleCellCall Results [AID1189, Type: other]
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13
[SID48414146]
DSSTox (CPDBAS) Carcinogenic Potency Database Salmonella Mutagenicity [AID1194, Type: other]
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14
[SID48414146]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary Rat Bioassay Results [AID1208, Type: other]
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15
[SID48416200]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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16
[SID8149406]
Suppression of Polyglutamine Toxicity in Whole Organism Drosophila Model of SCA1 (SCA1FLYe) [AID1595, Type: other]
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17
[SID8149406]
Suppression of Polyglutamine Toxicity in Whole Organism Drosophila Model of SCA1 (SCA1FLYp) [AID1597, Type: other]
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18
[SID103165035]
IC50 64The compound was evaluated for cytotoxicity by assessing 3H thymidine uptake in LNCaP cell line [AID100394, Type: Literature]
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19
[SID103165035]
IC50 70The compound was evaluated for cytotoxicity by assessing 3H thymidine uptake in MCF-7 cell line [AID101608, Type: Literature]
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20
[SID103165035]
In vivo toxicity against C3H/HeN cell line in mice expressed as maximal tolerated dose [AID115134, Type: Literature]
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21
[SID103165035]
in vivo activity against aerobic and hypoxic cells in RIF-1 tumors when administered at a dose of 17.8 umol/kg in mice [AID124094, Type: other]
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22
[SID103165035]
in vivo activity against aerobic and hypoxic cells in RIF-1 tumors when administered at a dose of 17.8 umol/kg in mice 30 min before exposure to radiation [AID124095, Type: Literature]
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23
[SID103165035]
in vivo activity against aerobic and hypoxic cells in RIF-1 tumors when administered at a dose of 17.8 umol/kg in mice after 5 min of exposure to radiation [AID124096, Type: Literature]
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24
[SID103165035]
Hypersensitivity factor is the ratio of IC50 for AA8/IC50 for UV4 cell line [AID215304, Type: Literature]
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25
[SID103165035]
Hypersensitivity factor which is a ratio of IC50 of AA8 cells to that of the UV4 cells [AID229938, Type: Literature]
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26
[SID103165035]
Toxicity in mouse harboring L1210 cells [AID596309, Type: Literature]
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27
[SID103165035]
Toxicity in mouse harboring P-388 cells [AID596310, Type: Literature]
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28
[SID103165035]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia [AID625279, Type: Literature]
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29
[SID103165035]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholecystitis [AID625280, Type: Literature]
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30
[SID103165035]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholelithiasis [AID625281, Type: Literature]
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31
[SID103165035]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cirrhosis [AID625282, Type: Literature]
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32
[SID103165035]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for elevated liver function tests [AID625283, Type: Literature]
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33
[SID103165035]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic failure [AID625284, Type: Literature]
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34
[SID103165035]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic necrosis [AID625285, Type: Literature]
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35
[SID103165035]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatitis [AID625286, Type: Literature]
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36
[SID103165035]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatomegaly [AID625287, Type: Literature]
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37
[SID103165035]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for jaundice [AID625288, Type: Literature]
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38
[SID103165035]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver disease [AID625289, Type: Literature]
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39
[SID103165035]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver fatty [AID625290, Type: Literature]
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40
[SID103165035]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver function tests abnormal [AID625291, Type: Literature]
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41
[SID103165035]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) combined score [AID625292, Type: Literature]
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42
[SID8149406]
Yeast cell-based screen for compounds that suppress polyglutamine aggregation in vivo (75Q-TubU) [AID1593, Type: other]
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43
[SID8149406]
Assay to identify inhibitors of polyglutamine-induced caspase-3 activation (CASP3) [AID1583, Type: other]
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44
[SID8149406]
Screen for compounds that selectively inhibit cytochrome c release from purified mitochondria (CytoCRel) [AID1603, Type: other]
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45
[SID8149406]
Screen for compounds that inhibit polyglutamine induced protein aggregation (AGREG) [AID1604, Type: other]
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46
[SID8149406]
Screening of compounds showing protective effect against cell death induced by familial amyotrophic lateral sclerosis (FALS)-linked mutantsuperoxide dismutase 1 (SOD1) (ALSOD1) [AID1605, Type: other]
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47
[SID8149406]
Screen for compounds that increase glutamate transport activity in MN-1 cell line (GluUPTAKE) [AID1612, Type: other]
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48
[SID8149406]
Screen for compounds that inhibit protein aggregation formed by mutant SOD1 (GFPSOD1) [AID1613, Type: other]
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49
[SID8149406]
Screen for compounds that reduce polyglutamine (polyQ) inclusions in nerve growth factor (NGF)-treated PC12 cells (GFPQ80) [AID1614, Type: other]
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50
[SID8149406]
Yeast cell-based screen for compounds that suppress polyglutamine aggregation in vivo (75Q-TubH) [AID1616, Type: other]
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