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BioActivity Data for Compound Mechlorethamine (CID 4033)

BioActivity Outcomes:
Active(19)
 
 
Inactive(69)
 
 
Inconclusive(44)
 
 
Unspecified(62)
 
 
Top Targets:
NAD binding 8(5)
 
 
PLDc mTdp1 2(3)
 
 
 
ePHD KMT2A(2)
 
 
Tubulin-bindi..(2)
 
 
 
Peptidase C1A(2)
 
 
BioAssay Types:
Literature(89)
 
 
 
 
 
Confirmatory(54)
 
 
 
Screening(4)
 
 
BioAssay Categories:
In vitro(3)
 
 
 
In vivo(6)
 
 
Biochemical(6)
 
 
Toxicity(35)
 
 
 
 
ADME(21)
 
 
Cell-based(26)
 
 
 
 
Organism-base..(2)
 
 
BioActivity Types:
Potency(51)
 
 
 
IC50(26)
 
 
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 189    Data Row: 194   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103165035]
IC50 0.029Ability to reduce cell density of UV4 cells to 50% after 4 hr of exposure to air [AID215463, Type: Literature]
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2
[SID103165035]
IC50 0.15Ability to reduce cell density of EMT6 cells to 50% after 4 hr of exposure to air [AID67761, Type: Literature]
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3
[SID103165035]
IC50 1.09Ability to reduce cell density of SKOV3 cells to 50% after 4 hr of exposure to air [AID205119, Type: Literature]
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4
[SID103165035]
IC50 2Cytotoxicity against AA8 cell and IC50 values were determined as drug concentration required to inhibit cell protein to 50%. [AID9488, Type: Literature]
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5
[SID103165035]
IC50 2.2Concentration for 50% inhibition of AA8 cells growth under aerobic conditions after 18 hours exposure [AID9681, Type: Literature]
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6
[SID103165035]
IC50 2.5Ability to reduce cell density of AA8 cells to 50% after 4 hr of exposure to air [AID9678, Type: Literature]
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7
[SID103165035]
IC50 7.6Growth inhibition of human DU145 cells after 3 days by SRB assay [AID288401, Type: Literature]
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8
[SID103165035]
IC50 7.6Induction of cell cycle arrest in human DU145 cells assessed as accumulation at mid-S phase at 10 uM after 24 hrs by flow cytometry [AID288406, Type: Literature]
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9
[SID103165035]
Ability to reduce surviving fraction of EMT6 cells to 10% when exposed to N2 for 3 hrs [AID67630, Type: Literature]
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10
[SID103165035]
Ability to reduce surviving fraction of EMT6 cells to 10% when exposed to air for 3 hrs [AID67631, Type: Literature]
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11
[SID103165035]
Hypoxic cytotoxicity ratio was determined [AID67632, Type: Literature]
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12
[SID103165035]
Alkylating activity of the compound assessed as alkylation of 4-(p-nitrobenzyl)pyridine at 2 x 10'-5 M after 20 mins by colorimetric analysis [AID1150116, Type: Literature]
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13
[SID48414146]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary SingleCellCall Results [AID1189, Type: other]
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14
[SID48414146]
DSSTox (CPDBAS) Carcinogenic Potency Database Salmonella Mutagenicity [AID1194, Type: other]
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15
[SID48414146]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary Rat Bioassay Results [AID1208, Type: other]
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16
[SID8149406]
Suppression of Polyglutamine Toxicity in Whole Organism Drosophila Model of SCA1 (SCA1FLYp) [AID1597, Type: other]
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17
[SID8149406]
Suppression of Polyglutamine Toxicity in Whole Organism Drosophila Model of SCA1 (SCA1FLYe) [AID1595, Type: other]
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18
[SID48416200]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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19
[SID103165035]
Stability of the compound at pH 4.18 [AID1145410, Type: Literature]
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20
[SID103165035]
IC50 64The compound was evaluated for cytotoxicity by assessing 3H thymidine uptake in LNCaP cell line [AID100394, Type: Literature]
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