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phenylmethylpyrazolone (CID 4021) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(48)
 
 
Inactive(1526)
 
 
Inconclusive(119)
 
 
Unspecified(190)
 
 
Top Targets:
7TM GPCR Srx(42)
 
 
 
NR LBD PPAR(40)
 
 
 
 
7TM GPCR Srsx(39)
 
 
 
NR LBD ER(30)
 
 
 
 
NR LBD AR(26)
 
 
 
 
BioAssay Types:
Confirmatory(805)
 
 
 
 
 
Screening(629)
 
 
 
 
Literature(135)
 
 
 
 
 
Summary(72)
 
 
 
 
BioActivity Types:
Potency(715)
 
 
 
 
 
IC50(177)
 
 
 
 
EC50(15)
 
 
 
 
AC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1308    Data Row: 1883   Total Pages: 38   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103219212]
IC50 0.25Hydroxy radical scavenging activity by ESR spin-trapping method [AID298289, Type: Literature]
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2
[SID855774]
AC50_uM 2.753Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Inhibitors of DnaB-Intein Splicing Activity [AID449749, Type: confirmatory]Probable replicative DNA helicase DnaB [Mycobacterium tuberculosis H37Rv] [gi:15607200]
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3
[SID855774]
EC50_uM 2.95Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of RecA-Intein Splicing Activity [AID435010, Type: confirmatory]RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)] [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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4
[SID855774]
EC50_uM 3.099Fluorescence Cell-Free Homogeneous Counter Screen to Identify Inhibitors of GFP Chromophore Formation [AID434968, Type: confirmatory]RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)] [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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5
[SID855774]
AC50_uM 3.243Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Non-Covalent Inhibitors of RecA-Intein Splicing Activity [AID449750, Type: confirmatory]Probable replicative DNA helicase DnaB [Mycobacterium tuberculosis H37Rv] [gi:15607200]
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6
[SID26757432]
Potency 3.9811Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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7
[SID26746991]
Potency 5.0119qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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8
[SID17389763]
Potency 10qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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9
[SID855774]
Potency 10qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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10
[SID144205630]
Potency-Replicate_1 11.8832qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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11
[SID144208945]
AhR Potency (uM) 16.0534qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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12
[SID144205630]
Ratio Potency (uM) 16.3953qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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13
[SID103219212]
IC50 17Antioxidant activity against Fe2SO4/ascorbate-induced lipid peroxidation in Wistar rat liver microsomal membrane by TBARS assay [AID412356, Type: Literature]
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14
[SID144213136]
AhR Potency (uM) 20.0875qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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15
[SID17389763]
Potency 25.1189qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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16
[SID144205630]
Potency-Replicate_1 26.6032qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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17
[SID103219212]
IC50 27Antioxidant effect assessed as DPPH radical scavenging activity [AID283751, Type: Literature]
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18
[SID103219212]
IC50 29.3Scavenging activity against DPPH [AID226891, Type: Literature]
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19
[SID103219212]
IC50 32Compound tested to inhibit (LPO) lipid peroxidation was determined in rat brain microsomes [AID181671, Type: Literature]
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20
[SID144208945]
Ratio Potency (uM) 61.5038qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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21
[SID144208945]
Potency-Replicate_1 61.5038qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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22
[SID103219212]
Stability in human serum at 250 uM by RP-HPLC analysis [AID700903, Type: Literature]
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23
[SID103219212]
Stability in 5% DMSO/0.1 M KCl by RP-HPLC analysis [AID700904, Type: Literature]
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24
[SID103219212]
Stability in 0.1 M HCl/MeOH 60/40 (v/v) mixture by RP-HPLC analysis [AID700907, Type: Literature]
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25
[SID103219212]
Anticerebral ischemic activity in Sprague-Dawley rat middle cerebral artery occlusion model assessed as reduction of water content in brain at 3 mg/kg, ig for 7 consecutive days [AID698757, Type: Literature]
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26
[SID855774]
Aqueous Solubility from MLSMR Stock Solutions [AID1996, Type: other]
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27
[SID103219212]
Neuroprotective effect against H202-induced Sprague-Dawley rat cortical neuron injury assessed as cell viability at 100 uM treated 30 mins before H202 challenge measured after 24 hrs by MTT assay [AID349364, Type: Literature]
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28
[SID855774]
Primary biochemical high-throughput screening assay for inhibitors of Rho kinase 2 (Rhok2) [AID604, Type: screening]rho-associated protein kinase 2 [Homo sapiens] [gi:41872583]
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29
[SID85148637]
Fluorescence-based biochemical high throughput screening primary assay to identify inhibitors of Crimean-Congo Hemorrhagic Fever (CCHF) viral ovarian tumor domain protease (vOTU): Pep-AMC substrate [AID651958, Type: screening]putative polyprotein [Crimean-Congo hemorrhagic fever virus] [gi:76364066]
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30
[SID855774]
IC50 AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation [AID2018, Type: confirmatory]SUMO1 activating enzyme subunit 1 [Homo sapiens] [gi:17390638]
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31
[SID855774]
Fluorescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of RecA Intein Splicing Activity [AID2221, Type: screening]RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)] [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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32
[SID855774]
Novel Modifiers of Toll-like and RIG-like Receptor Signaling-Poly IC Stimulus [AID602277, Type: screening]Toll-like receptor 3 [gi:20140422]
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33
[SID85148637]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide [AID686964, Type: screening]Methyl-CpG binding domain protein 2 [Homo sapiens] [gi:21595776]
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34
[SID85148637]
Epi Absorbance-based biochemical primary high throughput screening assay to identify inhibitors of human tyrosyl-DNA phosphodiesterase 2 (TDP2) [AID720702, Type: screening]tyrosyl-DNA phosphodiesterase 2 [Homo sapiens] [gi:23510348]
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35
[SID85148637]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID743269, Type: screening]integrase [Human immunodeficiency virus 1] [gi:2853980]
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36
[SID56422481]
Fluorescence polarization-based counterscreen for RBBP9 inhibitors: primary biochemical high throughput screening assay to identify inhibitors of the oxidoreductase glutathione S-transferase omega 1(GSTO1). [AID1974, Type: screening]glutathione S-transferase omega-1 isoform 1 [Homo sapiens] [gi:4758484]
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37
[SID855774]
IC50 AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation [AID2018, Type: confirmatory]SUMO-conjugating enzyme UBC9 [Homo sapiens] [gi:4507785]
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38
[SID85148637]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID743269, Type: screening]lens epithelium-derived growth factor p75 [Homo sapiens] [gi:6708281]
View
39
[SID855774]
IC50 AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation [AID2018, Type: confirmatory]Ubiquitin-like modifier activating enzyme 2 [Homo sapiens] [gi:13111961]
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40
[SID11113339]
p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450 1A2 [Homo sapiens] [gi:73915100]
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41
[SID11113339]
Cytochrome panel assay with activity outcomes [AID1851_4, Type: other]cytochrome P450 1A2 [Homo sapiens] [gi:73915100]
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42
[SID855774]
Primary biochemical high-throughput screening assay to measure P97 ATPase inhibition [AID1481, Type: screening]Valosin-containing protein [Homo sapiens] [gi:111305821]
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43
[SID855774]
Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - MK [AID555, Type: screening]mevalonate kinase [Streptococcus pneumoniae D39] [gi:116516899]
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44
[SID855774]
uHTS Fluorescent assay for identification of inhibitors of Apaf-1 [AID489030, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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45
[SID144213136]
qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway: Summary [AID743199, Type: summary]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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46
[SID56422481]
uHTS Fluorescent Assay Using Nedd8 Protein Substrate for Identification of Inhibitors of Sentrin-Specific Protease 8 (SENP8) [AID602440, Type: screening]sentrin-specific protease 8 [Homo sapiens] [gi:262118306]
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47
[SID56422481]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Protein Arginine Deiminase 4 (PAD4) (1536 HTS) [AID485272, Type: screening]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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48
[SID85148637]
Fluorescence-based biochemical high throughput primary assay to identify inhibitors of phospholipase C isozymes (PLC-gamma1). [AID720700, Type: screening]Phospholipase C, gamma 1 [Homo sapiens] [gi:223459640]
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49
[SID103219212]
IC50 1Antiprion activity in ScN2a cells assessed as inhibition of protease-resistant prion protein accumulation [AID298287, Type: Literature]
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50
[SID103219212]
IC50 250Hydroxyl radical scavenging activity by ESR spin-trapping method [AID276888, Type: Literature]
View