Maprotiline (CID 4011) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(81)
 
 
Inactive(767)
 
 
Inconclusive(104)
 
 
Unspecified(176)
 
 
Top Targets:
p450(44)
 
 
 
 
 
7TM GPCR Srx(36)
 
 
 
 
7TM GPCR Srsx(19)
 
 
 
 
P53(8)
 
 
 
 
PLN02808(8)
 
 
BioAssay Types:
Confirmatory(456)
 
 
 
 
 
Screening(333)
 
 
 
 
Literature(160)
 
 
 
 
 
BioActivity Types:
Potency(356)
 
 
 
 
 
IC50(163)
 
 
 
 
 
Ki(7)
 
 
 
EC50(4)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 843    Data Row: 1128   Total Pages: 23   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID123092441]
Ki 0.00167Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells [AID392464, Type: Literature]Histamine H1 receptor [gi:547645]
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2
[SID123092441]
Ki 0.00167Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells [AID392464, Type: Literature]Histamine H1 receptor [gi:547645]
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3
[SID123092441]
IC50 0.00879DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) [AID625269, Type: other]Histamine H1 receptor [gi:547645]
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4
[SID123092441]
IC50 0.00879DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) [AID625269, Type: other]Histamine H1 receptor [gi:547645]
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5
[SID123092441]
Ki 0.012Inhibition of norepinephrine reuptake at NET [AID452389, Type: Literature]
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6
[SID123092441]
IC50 0.03DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625207, Type: other]Sodium-dependent noradrenaline transporter [gi:128616]
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7
[SID123092441]
IC50 0.03DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625207, Type: other]Sodium-dependent noradrenaline transporter [gi:128616]
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8
[SID123092441]
IC50 0.064DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) [AID625192, Type: other]5-hydroxytryptamine receptor 2A [gi:543727]
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9
[SID123092441]
IC50 0.064DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) [AID625192, Type: other]5-hydroxytryptamine receptor 2A [gi:543727]
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10
[SID123092441]
IC50 0.064DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) [AID625192, Type: other]5-hydroxytryptamine receptor 2A [gi:543727]
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11
[SID123092441]
IC50 0.078DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) [AID625218, Type: other]5-hydroxytryptamine receptor 2C [gi:112816]
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12
[SID123092441]
IC50 0.078DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) [AID625218, Type: other]5-hydroxytryptamine receptor 2C [gi:112816]
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13
[SID123092441]
IC50 0.078DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) [AID625218, Type: other]5-hydroxytryptamine receptor 2C [gi:112816]
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14
[SID123092441]
IC50 0.16DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625155, Type: other]Muscarinic acetylcholine receptor M [gi:543761]
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15
[SID123092441]
IC50 0.16DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625155, Type: other]Muscarinic acetylcholine receptor M [gi:543761]
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16
[SID123092441]
IC50 0.16DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625155, Type: other]Muscarinic acetylcholine receptor M [gi:543761]
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17
[SID123092441]
IC50 0.16DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625155, Type: other]Muscarinic acetylcholine receptor M [gi:543761]
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18
[SID123092441]
IC50 0.163DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) [AID625199, Type: other]Alpha-1B adrenergic receptor [gi:543734]
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19
[SID123092441]
IC50 0.163DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) [AID625199, Type: other]Alpha-1B adrenergic receptor [gi:543734]
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20
[SID123092441]
IC50 0.292DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) [AID625202, Type: other]Alpha-2B adrenergic receptor [gi:27151763]
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21
[SID123092441]
IC50 0.292DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) [AID625202, Type: other]Alpha-2B adrenergic receptor [gi:27151763]
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22
[SID123092441]
IC50 0.336DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625217, Type: other]5-hydroxytryptamine receptor 2B [gi:1168220]
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23
[SID123092441]
IC50 0.336DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625217, Type: other]5-hydroxytryptamine receptor 2B [gi:1168220]
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24
[SID123092441]
IC50 0.336DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625217, Type: other]5-hydroxytryptamine receptor 2B [gi:1168220]
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25
[SID123092441]
IC50 0.373DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) [AID625252, Type: other]D(1A) dopamine receptor [gi:118228]
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26
[SID123092441]
IC50 0.373DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) [AID625252, Type: other]D(1A) dopamine receptor [gi:118228]
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27
[SID123092441]
IC50 0.373DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) [AID625252, Type: other]D(1A) dopamine receptor [gi:118228]
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28
[SID123092441]
IC50 0.373DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) [AID625252, Type: other]D(1A) dopamine receptor [gi:118228]
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29
[SID123092441]
IC50 0.397DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625200, Type: other]Alpha-1D adrenergic receptor [gi:1168243]
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30
[SID123092441]
IC50 0.397DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625200, Type: other]Alpha-1D adrenergic receptor [gi:1168243]
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31
[SID123092441]
IC50 0.397DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625200, Type: other]Alpha-1D adrenergic receptor [gi:1168243]
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32
[SID123092441]
IC50 0.4DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine) [AID625270, Type: other]Histamine H2 receptor [gi:123120]
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33
[SID123092441]
IC50 0.4DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine) [AID625270, Type: other]Histamine H2 receptor [gi:123120]
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34
[SID123092441]
IC50 0.4DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine) [AID625270, Type: other]Histamine H2 receptor [gi:123120]
View
35
[SID123092441]
Ki 0.402Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells [AID392465, Type: Literature]D(1A) dopamine receptor [gi:118228]
View
36
[SID123092441]
Ki 0.402Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells [AID392465, Type: Literature]D(1A) dopamine receptor [gi:118228]
View
37
[SID123092441]
Ki 0.402Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells [AID392465, Type: Literature]D(1A) dopamine receptor [gi:118228]
View
38
[SID123092441]
Ki 0.402Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells [AID392465, Type: Literature]D(1A) dopamine receptor [gi:118228]
View
39
[SID123092441]
IC50 0.413DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625154, Type: other]Muscarinic acetylcholine receptor M [gi:23503039]
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40
[SID123092441]
IC50 0.413DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625154, Type: other]Muscarinic acetylcholine receptor M [gi:23503039]
View
41
[SID123092441]
IC50 0.413DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625154, Type: other]Muscarinic acetylcholine receptor M [gi:23503039]
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42
[SID123092441]
Ki 0.429Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells [AID392466, Type: Literature]D(1B) dopamine receptor [gi:118214]
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43
[SID123092441]
Ki 0.429Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells [AID392466, Type: Literature]D(1B) dopamine receptor [gi:118214]
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44
[SID123092441]
Ki 0.429Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells [AID392466, Type: Literature]D(1B) dopamine receptor [gi:118214]
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45
[SID123092441]
IC50 0.446DRUGMATRIX: Calcium Channel Type L, Phenylalkylamine radioligand binding (ligand: [3H] (-)-Desmethoxyverapamil (D-888)) [AID625234, Type: other]
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46
[SID123092441]
IC50 0.473DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625153, Type: other]Muscarinic acetylcholine receptor M [gi:113125]
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47
[SID123092441]
IC50 0.473DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625153, Type: other]Muscarinic acetylcholine receptor M [gi:113125]
View
48
[SID123092441]
IC50 0.473DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625153, Type: other]Muscarinic acetylcholine receptor M [gi:113125]
View
49
[SID123092441]
IC50 0.473DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625153, Type: other]Muscarinic acetylcholine receptor M [gi:113125]
View
50
[SID123092441]
IC50 0.473DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625153, Type: other]Muscarinic acetylcholine receptor M [gi:113125]
View