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Maprotiline (CID 4011) - Compound BioActivity Data
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BioActivity Outcomes:
Active(98)
 
 
Inactive(943)
 
 
Inconclusive(127)
 
 
Unspecified(344)
 
 
Top Targets:
7TM GPCR Srx(46)
 
 
 
 
p450(43)
 
 
 
 
 
7TM GPCR Srsx(37)
 
 
 
 
HSD10-like SD..(12)
 
 
NR LBD GR(11)
 
 
 
BioAssay Types:
Confirmatory(697)
 
 
 
 
 
Screening(390)
 
 
 
 
Literature(194)
 
 
 
 
 
Summary(24)
 
 
 
 
BioActivity Types:
Potency(490)
 
 
 
 
 
IC50(167)
 
 
 
 
 
Ki(7)
 
 
 
EC50(6)
 
 
 
AC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1152    Data Row: 1512   Total Pages: 76   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103189345]
Ki 0.00167Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells [AID392464, Type: Literature]Histamine H1 receptor [gi:547645]
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2
[SID103189345]
IC50 0.00879DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) [AID625269, Type: confirmatory]Histamine H1 receptor [gi:547645]
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3
[SID103189345]
Ki 0.012Inhibition of norepinephrine reuptake at NET [AID452389, Type: Literature]
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4
[SID103189345]
IC50 0.03DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625207, Type: confirmatory]Sodium-dependent noradrenaline transporter [gi:128616]
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5
[SID103189345]
IC50 0.064DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) [AID625192, Type: confirmatory]5-hydroxytryptamine receptor 2A [gi:543727]
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6
[SID103189345]
IC50 0.078DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) [AID625218, Type: confirmatory]5-hydroxytryptamine receptor 2C [gi:112816]
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7
[SID103189345]
IC50 0.16DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625155, Type: confirmatory]Muscarinic acetylcholine receptor M5 [gi:543761]
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8
[SID103189345]
IC50 0.163DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) [AID625199, Type: confirmatory]Alpha-1B adrenergic receptor [gi:543734]
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9
[SID103189345]
IC50 0.292DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) [AID625202, Type: confirmatory]Alpha-2B adrenergic receptor [gi:27151763]
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10
[SID103189345]
IC50 0.336DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625217, Type: confirmatory]5-hydroxytryptamine receptor 2B [gi:1168220]
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11
[SID103189345]
IC50 0.373DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) [AID625252, Type: confirmatory]D(1A) dopamine receptor [gi:118228]
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12
[SID103189345]
IC50 0.397DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625200, Type: confirmatory]Alpha-1D adrenergic receptor [gi:1168243]
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13
[SID103189345]
IC50 0.4DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine) [AID625270, Type: confirmatory]Histamine H2 receptor [gi:123120]
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14
[SID103189345]
Ki 0.402Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells [AID392465, Type: Literature]D(1A) dopamine receptor [gi:118228]
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15
[SID103189345]
IC50 0.413DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625154, Type: confirmatory]Muscarinic acetylcholine receptor M4 [gi:23503039]
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16
[SID103189345]
Ki 0.429Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells [AID392466, Type: Literature]D(1B) dopamine receptor [gi:118214]
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17
[SID103189345]
IC50 0.446DRUGMATRIX: Calcium Channel Type L, Phenylalkylamine radioligand binding (ligand: [3H] (-)-Desmethoxyverapamil (D-888)) [AID625234, Type: confirmatory]
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18
[SID103189345]
IC50 0.473DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625153, Type: confirmatory]Muscarinic acetylcholine receptor M3 [gi:113125]
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19
[SID103189345]
Ki 0.504Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells [AID392468, Type: Literature]D(3) dopamine receptor [gi:1169206]
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20
[SID90341780]
Potency 0.5212High Content Imaging Cell-Based qHTS for Inhibitors of the mTORC1 Signaling Pathway in MEF Cells [AID2667, Type: confirmatory]serine/threonine-protein kinase mTOR [Homo sapiens] [gi:4826730]
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