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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (CID 3973) - Compound BioActivity Data
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BioActivity Outcomes:
Active(194)
 
 
Inactive(327)
 
 
Inconclusive(50)
 
 
Unspecified(798)
 
 
Top Targets:
7tm 4(38)
 
 
 
 
CYCLIN(28)
 
 
 
p450(26)
 
 
 
 
 
PI3Kc IA alph..(17)
 
 
 
 
PKc like(16)
 
 
 
BioAssay Types:
Literature(853)
 
 
 
 
 
Confirmatory(460)
 
 
 
 
 
Screening(14)
 
 
 
BioActivity Types:
IC50(252)
 
 
 
 
 
Potency(238)
 
 
 
 
 
Ki(5)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1178    Data Row: 1369   Total Pages: 69   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103309971]
IC50 0.2Inhibition of PI3Kalpha by luminescent kinase glo assay [AID349505, Type: Literature]
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2
[SID103309971]
IC50 0.22Inhibition of PI-3K delta (unknown origin) [AID768757, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [gi:67477424]
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3
[SID103309971]
IC50 0.27Inhibition of PI-3K beta (unknown origin) [AID768759, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [gi:1171955]
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4
[SID103309971]
IC50 0.3Inhibition of PI-3K alpha (unknown origin) [AID768760, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [gi:126302584]
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5
[SID103309971]
IC50 0.306Inhibition of human PI3Kbeta [AID266956, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [gi:1171955]
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6
[SID103309971]
IC50 0.31Inhibition of PI3Kbeta using phosphatidylinositol as substrate by gamma33P[ATP] incorporation assay [AID719916, Type: Literature]
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7
[SID103309971]
IC50 0.34Inhibition of p110beta [AID290462, Type: Literature]
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8
[SID103309971]
IC50 0.34Inhibition of GST-tagged human PI3K p110-beta by SPA [AID284034, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [gi:1171955]
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9
[SID103309971]
IC50 0.34Inhibition of GST-tagged human p110-beta expressed in SF9/Baculovirus system by SPA [AID289255, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [gi:1171955]
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10
[SID103309971]
IC50 0.356Inhibition of PI3K p110alpha (unknown origin) [AID729015, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [gi:126302584]
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11
[SID103309971]
IC50 0.38Inhibition of epithelial growth factor-induced cell migration of human MDA-MB-231 cells pre-incubated for 24 hrs by cell invasion assay [AID684637, Type: Literature]
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12
[SID90341244]
Potency 0.414High Content Imaging Cell-Based qHTS for Inhibitors of the mTORC1 Signaling Pathway in MEF Cells [AID2667, Type: confirmatory]serine/threonine-protein kinase mTOR [Homo sapiens] [gi:4826730]
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13
[SID103309971]
IC50 0.5Inhibition of PI3Kalpha after 80 mins [AID568857, Type: Literature]
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14
[SID103309971]
IC50 0.5Inhibition of recombinant PI3Kdelta expressed in baculovirus-infected Sf21 cells [AID446235, Type: Literature]
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15
[SID103309971]
IC50 0.5Inhibition of mouse recombinant PI3Kalpha expressed in baculovirus-infected Sf21 cells [AID446234, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [gi:341941258]
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16
[SID103309971]
IC50 0.5Inhibition of mouse wild type PI3Kalpha expressed in Sf21 cells co-expressing N-terminal His-tagged human p85a using L-alpha-phosphatidylinositol substrate by TLC based phosphor imaging [AID657643, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [gi:341941258]
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17
[SID103309971]
IC50 0.55Inhibition of human PI3Kalpha expressed in Sf9 cells by fluorescent polarization assay [AID549470, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [gi:126302584]
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18
[SID103309971]
IC50 0.57Inhibition of PI3Kdelta expressed in cells co-expressing N-terminal His-tagged human p85a using L-alpha-phosphatidylinositol substrate by TLC based phosphor imaging [AID657645, Type: Literature]
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19
[SID103309971]
IC50 0.63Inhibition of PI3Kalpha using diC8-PI(4,5)P2 as substrate after 3 hrs by competitive fluorescence polarization assay [AID657255, Type: Literature]
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20
[SID103309971]
IC50 0.63Inhibition of p110alpha by SPA assay [AID290460, Type: Literature]
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