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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (CID 3973) - Compound BioActivity Data
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BioActivity Outcomes:
Active(181)
 
 
Inactive(326)
 
 
Inconclusive(50)
 
 
Unspecified(793)
 
 
Top Targets:
PKc like(65)
 
 
 
PKc(62)
 
 
 
STKc AGC(31)
 
 
 
CYCLIN(28)
 
 
 
p450(26)
 
 
 
 
 
BioAssay Types:
Confirmatory(342)
 
 
 
 
 
Literature(318)
 
 
 
 
 
Screening(14)
 
 
 
BioActivity Types:
IC50(239)
 
 
 
 
 
Potency(237)
 
 
 
 
 
Ki(4)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1162    Data Row: 1350   Total Pages: 27   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103309971]
IC50 0.2Inhibition of PI3Kalpha by luminescent kinase glo assay [AID349505, Type: Literature]
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2
[SID103309971]
IC50 0.306Inhibition of human PI3Kbeta [AID266956, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [gi:1171955]
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3
[SID103309971]
IC50 0.31Inhibition of PI3Kbeta using phosphatidylinositol as substrate by gamma33P[ATP] incorporation assay [AID719916, Type: Literature]
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4
[SID103309971]
IC50 0.34Inhibition of p110beta [AID290462, Type: Literature]
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5
[SID103309971]
IC50 0.34Inhibition of GST-tagged human p110-beta expressed in SF9/Baculovirus system by SPA [AID289255, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [gi:1171955]
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6
[SID103309971]
IC50 0.34Inhibition of GST-tagged human PI3K p110-beta by SPA [AID284034, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [gi:1171955]
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7
[SID103309971]
IC50 0.356Inhibition of PI3K p110alpha (unknown origin) [AID729015, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [gi:126302584]
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8
[SID103309971]
IC50 0.38Inhibition of epithelial growth factor-induced cell migration of human MDA-MB-231 cells pre-incubated for 24 hrs by cell invasion assay [AID684637, Type: Literature]
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9
[SID90341244]
Potency 0.414High Content Imaging Cell-Based qHTS for Inhibitors of the mTORC1 Signaling Pathway in MEF Cells [AID2667, Type: confirmatory]serine/threonine-protein kinase mTOR [Homo sapiens] [gi:4826730]
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10
[SID103309971]
IC50 0.5Inhibition of recombinant PI3Kdelta expressed in baculovirus-infected Sf21 cells [AID446235, Type: Literature]
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11
[SID103309971]
IC50 0.5Inhibition of PI3Kalpha after 80 mins [AID568857, Type: Literature]
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12
[SID103309971]
IC50 0.5Inhibition of mouse wild type PI3Kalpha expressed in Sf21 cells co-expressing N-terminal His-tagged human p85a using L-alpha-phosphatidylinositol substrate by TLC based phosphorimaging [AID657643, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [gi:341941258]
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13
[SID103309971]
IC50 0.5Inhibition of mouse recombinant PI3Kalpha expressed in baculovirus-infected Sf21 cells [AID446234, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [gi:341941258]
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14
[SID103309971]
IC50 0.55Inhibition of human PI3Kalpha expressed in Sf9 cells by fluorescent polarization assay [AID549470, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [gi:126302584]
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15
[SID103309971]
IC50 0.57Inhibition of PI3Kdelta expressed in cells co-expressing N-terminal His-tagged human p85a using L-alpha-phosphatidylinositol substrate by TLC based phosphorimaging [AID657645, Type: Literature]
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16
[SID103309971]
IC50 0.63Inhibition of PI3Kalpha using diC8-PI(4,5)P2 as substrate after 3 hrs by competitive fluorescence polarization assay [AID657255, Type: Literature]
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17
[SID103309971]
IC50 0.63Inhibition of p110alpha by SPA assay [AID290460, Type: Literature]
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18
[SID103309971]
IC50 0.63Inhibition of GST-tagged bovine p110-alpha expressed in SF9/Baculovirus system by SPA [AID289254, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [gi:417433]
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19
[SID103309971]
IC50 0.63Inhibition of GST-tagged bovine PI3K p110-alpha by SPA [AID284032, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [gi:417433]
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20
[SID103309971]
IC50 0.72Inhibition of human PI3Kalpha [AID266954, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [gi:126302584]
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21
[SID103309971]
IC50 0.73Inhibition of PI3Kalpha using phosphatidylinositol as substrate by gamma33P[ATP] incorporation assay [AID719917, Type: Literature]
View
22
[SID103309971]
IC50 0.736Inhibition of PI3K p110beta (unknown origin) [AID729014, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [gi:1171955]
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23
[SID103309971]
IC50 0.82Inhibition of PIM1 in the presence of 20uM ATP [AID435211, Type: Literature]Serine/threonine-protein kinase pim-1 [gi:83305339]
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24
[SID103309971]
IC50 0.9Inhibition of human recombinant PI3Kbeta expressed in baculovirus-infected Sf21 cells [AID446233, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [gi:1171955]
View
25
[SID103309971]
IC50 0.97Inhibition of human wild type PI3Kbeta expressed in Sf21 cells co-expressing N-terminal His-tagged human p85a using L-alpha-phosphatidylinositol substrate by TLC based phosphorimaging [AID657644, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [gi:1171955]
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26
[SID103309971]
IC50 1DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625245, Type: other]Cytochrome P450 1A2 [gi:117144]
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27
[SID103309971]
IC50 1.002DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) [AID625218, Type: other]5-hydroxytryptamine receptor 2C [gi:112816]
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28
[SID103309971]
IC50 1.01Inhibition of SCF1-induced PKB/Akt phosphorylation in THP1 cells [AID267044, Type: Literature]
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29
[SID103309971]
IC50 1.05Inhibition of PI3Kdelta using phosphatidylinositol as substrate by gamma33P[ATP] incorporation assay [AID719914, Type: Literature]
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30
[SID103309971]
IC50 1.06Inhibition of mTOR (unknown origin) [AID729011, Type: Literature]Serine/threonine-protein kinase mTOR [gi:1169735]
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31
[SID103309971]
IC50 1.09Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/cytochalasin B-induced superoxide anion production after 5 mins by spectrophotometer analysis [AID603125, Type: Literature]
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32
[SID103309971]
IC50 1.12Antiinflammatory activity against human neutrophil assessed as inhibition of N-formyl-l-methionyl phenylalanine/cytochalasin B-induced superoxide anion generation by spectrophotometry [AID579632, Type: Literature]
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33
[SID103309971]
IC50 1.12Antiinflammatory activity in FMLP/CB activated human neutrophils assessed as inhibition of superoxide generation by ferricytochrome c reduction based spectrophotometry [AID731036, Type: Literature]
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34
[SID103309971]
IC50 1.2Inhibition of PI3Kgamma by luminescent kinase glo assay [AID349506, Type: Literature]
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35
[SID103309971]
IC50 1.2Inhibitory activity against DNA-dependent protein kinase (DNA-PK) [AID241618, Type: Literature]DNA-dependent protein kinase catalytic subunit [gi:38258929]
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36
[SID103309971]
IC50 1.3Inhibition of DNA-PK [AID568856, Type: Literature]
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37
[SID103309971]
IC50 1.3Inhibition of PI3K in human PC3 cells assessed as decrease in AKT phosphorylation at serine 473 after 30 mins by ELISA [AID729010, Type: Literature]
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38
[SID103309971]
IC50 1.33Inhibition of human PI3Kdelta [AID266957, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [gi:67477424]
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39
[SID103309971]
IC50 1.4Inhibition of DNA-dependent protein kinase (DNA-PK) of HeLa cell nuclear cell extract [AID57387, Type: Literature]DNA-dependent protein kinase catalytic subunit [gi:38258929]
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40
[SID103309971]
IC50 1.4Inhibition of PIM3 in the presence of 20uM ATP [AID435577, Type: Literature]Serine/threonine-protein kinase pim-3 [gi:215274221]
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41
[SID103309971]
IC50 1.4Inhibition of Phoshoinositol 3 kinase [AID155499, Type: Literature]
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42
[SID103309971]
IC50 1.4In vitro inhibition of DNA-dependent protein kinase(DNA-PK) from HeLa (human carcinoma) cells. [AID57384, Type: Literature]
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43
[SID103309971]
IC50 1.4Inhibition of PI3K [AID325654, Type: Literature]
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44
[SID103309971]
IC50 1.47Inhibition of DNA dependent protein kinase isolated from HeLa cells [AID241691, Type: Literature]DNA-dependent protein kinase catalytic subunit [gi:38258929]
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45
[SID103309971]
IC50 1.47Inhibitory activity against DNA-dependent protein kinase receptor [AID257403, Type: Literature]DNA-dependent protein kinase catalytic subunit [gi:38258929]
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46
[SID103309971]
IC50 1.6Inhibition of His-tagged human p110gamma expressed in SF9/Baculovirus system by SPA [AID289256, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [gi:92090623]
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47
[SID103309971]
IC50 1.6Inhibition of His-tagged PI3K p110gamma by SPA [AID284035, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [gi:92090623]
View
48
[SID103309971]
IC50 1.6Inhibition of DNA-dependent protein kinase [AID364840, Type: Literature]
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49
[SID103309971]
IC50 1.6Inhibition of p110gamma [AID290463, Type: Literature]
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50
[SID103309971]
IC50 1.6Inhibition of DNA-dependent protein kinase [AID484153, Type: Literature]
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