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Loxapine (CID 3964) - Compound BioActivity Data
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BioActivity Outcomes:
Active(44)
 
 
Inactive(80)
 
 
Inconclusive(5)
 
 
Unspecified(53)
 
 
Top Targets:
7TM GPCR Srsx(8)
 
 
 
7TM GPCR Srx(8)
 
 
 
 
Pyr redox dim(4)
 
 
PIKKc TOR(4)
 
 
SIS(3)
 
 
BioAssay Types:
Literature(90)
 
 
 
 
 
Confirmatory(71)
 
 
 
 
Screening(14)
 
 
BioActivity Types:
Potency(70)
 
 
 
 
Ki(10)
 
 
IC50(9)
 
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 166    Data Row: 182   Total Pages: 10   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103218455]
Ki 0.00242Displacement of [3H]ketanserin from human recombinant 5HT2A receptor expressed in CHO cells after 60 mins by liquid scintillation counting [AID659850, Type: Literature]5-hydroxytryptamine receptor 2A [gi:543727]
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2
[SID103218455]
Ki 0.0049Affinity was evaluated by inhibition of [3H]-spiperone binding to COS cells transfected with human dopamine D-4 receptor [AID64202, Type: Literature]
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3
[SID103218455]
Ki 0.0049Ability to inhibit the binding of [3H]spiperone to the Dopamine receptor D4 in COS7 cells [AID65954, Type: Literature]
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4
[SID103218455]
IC50 0.006Binding affinity towards 5-hydroxytryptamine 2A receptor from rat frontal cortex using [3H]ketanserin as radioligand [AID5483, Type: Literature]
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5
[SID103218455]
Ki 0.009Displacement of [3H]-YM09151-2 from human cloned dopamine D4 receptor expressed in insect Sf9 cells after 60 mins by liquid scintillation counting [AID659851, Type: Literature]D(4) dopamine receptor [gi:1345939]
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6
[SID103218455]
IC50 0.014Compound was tested in vitro for its binding affinity towards human Dopamine receptor D4.2 [AID63865, Type: Literature]
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7
[SID103218455]
Ki 0.015Binding affinity towards human 5-hydroxytryptamine 6 receptor [AID6563, Type: Literature]
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8
[SID103218455]
IC50 0.018In vitro binding affinity towards Alpha-1 adrenergic receptor by the displacement of [3H]prazosin radioligand in rat cortical homogenates [AID36855, Type: Literature]
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9
[SID103218455]
Ki 0.021Affinity was evaluated by inhibition of [3H]spiperone binding to COS cells transfected with human dopamine D-2(long) receptor [AID64197, Type: Literature]
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10
[SID103218455]
Ki 0.021Ability to inhibit the binding of [3H]spiperone to the Dopamine receptor D2L in COS7 cells [AID64327, Type: Literature]
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11
[SID103218455]
Ki 0.021In vitro binding affinity towards Dopamine receptor D2 in rat tissue homogenate using [3H]-spiperone as radioligand [AID65733, Type: Literature]
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12
[SID103218455]
IC50 0.022Binding affinity towards human Dopamine receptor D3 [AID64825, Type: Literature]
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13
[SID103218455]
Ki 0.043Binding affinity towards rat 5-hydroxytryptamine 7 receptor [AID6648, Type: Literature]
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14
[SID103218455]
Ki 0.05Binding affinity for human 5-hydroxytryptamine 6 receptor [AID238747, Type: Literature]5-hydroxytryptamine receptor 6 [gi:1703010]
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15
[SID103218455]
IC50 0.054Compound was tested in vitro for its binding affinity towards human Dopamine receptor D2 [AID61306, Type: Literature]
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16
[SID90341467]
Potency 0.3981HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Antagonists [AID488983, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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17
[SID103218455]
IC50 1Compound was tested in vitro for its binding affinity towards 5-hydroxytryptamine 2C receptor from rat using [3H]mesulergine as radioligand [AID5704, Type: Literature]
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18
[SID103218455]
IC50 1Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligand [AID87514, Type: Literature]
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19
[SID103218455]
IC50 5.5Inhibition of binding of 1.0 nM [3H]pirenzepine to cloned human Muscarinic acetylcholine receptor M1 expressed in membranes from CHO-K1 cells [AID141053, Type: Literature]
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20
[SID90341467]
Potency 11.5774qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [Marburg marburgvirus] [gi:420597]
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