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Loperamide (CID 3955) - Compound BioActivity Data
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BioActivity Outcomes:
Active(141)
 
 
Inactive(411)
 
 
Inconclusive(101)
 
 
Unspecified(246)
 
 
Top Targets:
7tm 4(46)
 
 
 
 
 
p450(39)
 
 
 
 
 
ABC MTABC3 MD..(13)
 
 
HSD10-like SD..(12)
 
 
NR LBD TR(11)
 
 
 
 
BioAssay Types:
Confirmatory(579)
 
 
 
 
 
Literature(172)
 
 
 
 
 
Screening(27)
 
 
 
Summary(24)
 
 
 
BioActivity Types:
Potency(408)
 
 
 
 
IC50(121)
 
 
 
 
EC50(5)
 
 
Ki(4)
 
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 582    Data Row: 899   Total Pages: 45   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103220983]
Ki 0.00016Binding affinity for Mu opioid receptor of rat brain [AID238656, Type: Literature]
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2
[SID103220983]
Ki 0.00053Binding affinity for recombinant human mu-opioid receptor was determined by using [3H]- diprenophine radioligand [AID239449, Type: Literature]Mu-type opioid receptor [gi:2851402]
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3
[SID103220983]
IC50 0.00145DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) [AID625163, Type: confirmatory]Mu-type opioid receptor [gi:2851402]
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4
[SID11113732]
Potency 0.0158qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6 [AID891, Type: confirmatory]cytochrome P450 2D6 isoform 1 [Homo sapiens] [gi:40805836]
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5
[SID103220983]
Ki 0.0501Binding affinity for delta opioid receptor of rat brain [AID238717, Type: Literature]
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6
[SID103220983]
EC50 0.058Inhibition of mu opioid receptor mediated GTPgammaS binding to CHO cell membranes [AID246293, Type: Literature]Mu-type opioid receptor [gi:3024265]
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7
[SID103220983]
IC50 0.093DRUGMATRIX: Sodium Channel, Site 2 radioligand binding (ligand: [3H] Batrachotoxin) [AID625225, Type: confirmatory]
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8
[SID103220983]
EC50 0.156Inhibition of delta opioid receptor mediated GTPgammaS binding to CHO cell membranes [AID246309, Type: Literature]
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9
[SID103220983]
IC50 0.221DRUGMATRIX: Calcium Channel Type L, Benzothiazepine radioligand binding (ligand: [3H] Diltiazem) [AID625215, Type: confirmatory]
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10
[SID103220983]
IC50 0.27Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex [AID205267, Type: Literature]
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11
[SID103220983]
EC50 0.4889Inhibition of isolated guinea pig ileum contraction induced by electrical stimulation [AID246131, Type: Literature]
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12
[SID103220983]
IC50 0.589DRUGMATRIX: Calcium Channel Type L, Phenylalkylamine radioligand binding (ligand: [3H] (-)-Desmethoxyverapamil (D-888)) [AID625234, Type: confirmatory]
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13
[SID103220983]
IC50 0.628DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) [AID625223, Type: confirmatory]Sigma non-opioid intracellular receptor 1 [gi:74752153]
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14
[SID103220983]
IC50 0.896DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole) [AID625161, Type: confirmatory]Delta-type opioid receptor [gi:311033488]
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15
[SID103220983]
IC50 0.965DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) [AID625199, Type: confirmatory]Alpha-1B adrenergic receptor [gi:543734]
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16
[SID11111380]
Potency 1.2589qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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17
[SID90340730]
Potency 1.2589qHTS Assay for Identifying Gametocytocidal Compounds [AID743244, Type: confirmatory]
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18
[SID103220983]
IC50 1.337DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) [AID625254, Type: confirmatory]D(3) dopamine receptor [gi:1169206]
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19
[SID103220983]
IC50 1.379DRUGMATRIX: Sigma2 radioligand binding (ligand: [3H] Ifenprodil) [AID625224, Type: confirmatory]
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20
[SID103220983]
IC50 2DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625249, Type: confirmatory]Cytochrome P450 2D6 [gi:84028191]
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