lomerizine (CID 3949) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(56)
 
 
Inactive(26)
 
 
Inconclusive(21)
 
 
Unspecified(5)
 
 
Top Targets:
Tenui N(2)
 
 
DUF3652(2)
 
 
 
Geminin(2)
 
 
 
PMP22 Claudin(2)
 
 
 
Menin(2)
 
 
BioAssay Types:
Literature(72)
 
 
 
 
Confirmatory(32)
 
 
 
 
BioActivity Types:
Potency(30)
 
 
 
 
IC50(5)
 
 
EC50(2)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 46    Data Row: 108   Total Pages: 3   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103200142]
IC50 0.026Inhibition of [3H]BTX binding to cardiac voltage-gated sodium channel [AID217926, Type: Literature]
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2
[SID103200142]
IC50 0.09Blocking of rat N-type calcium channel alpha-1B/alpha-2-delta-1/beta-1b activity expressed in HEK293 cells assessed as whole cell current by whole cell patch clamp assay [AID471769, Type: Literature]
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3
[SID103200142]
IC50 0.15Blocking of rat Voltage-dependent L-type calcium channel alpha1c/alpha2delta-1/beta1b activity expressed in HEK293 cells assessed as whole cell current by whole cell patch clamp assay [AID472026, Type: Literature]
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4
[SID103200142]
IC50 1.48Inhibition of calcium channel L type in IMR32 cells [AID293102, Type: Literature]
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5
[SID103200142]
IC50 2.43Inhibition of calcium channel Cav2.2 in IMR32 cells [AID293101, Type: Literature]Voltage-dependent N-type calcium channel subunit alpha-1B [gi:1705854]
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6
[SID103200142]
IC50 2.43Inhibition of calcium channel Cav2.2 in IMR32 cells [AID293101, Type: Literature]Voltage-dependent N-type calcium channel subunit alpha-1B [gi:1705854]
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7
[SID26757962]
Potency 6.7456Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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8
[SID103200142]
EC50 9Antitrypanosomal activity against Trypanosoma cruzi amastigotes infected in BESM cells measured after 88 hrs postinfection by HTS assay [AID547622, Type: Literature]
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9
[SID26757962]
Potency 9.5283Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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10
[SID26757962]
Potency 10.1815S16 Schwann cell PMP22 intronic element firefly luciferase assay [AID624032, Type: confirmatory]Pmp22 gene product [Rattus norvegicus] [gi:8393992]
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11
[SID26757962]
Potency 21.136A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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12
[SID103200142]
EC50 22Cytotoxicity against BESM cells after 88 hrs by HTS assay [AID547621, Type: Literature]
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13
[SID26757962]
Potency 28.6954S16 Schwann cell viability assay (CellTiter-Glo assay) [AID624031, Type: confirmatory]
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14
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_50, Type: Literature]
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15
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_42, Type: Literature]
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16
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_44, Type: Literature]
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17
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_46, Type: Literature]
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18
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_47, Type: Literature]
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19
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_48, Type: Literature]
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20
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_52, Type: Literature]
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21
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_53, Type: Literature]
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22
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_54, Type: Literature]
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23
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_55, Type: Literature]
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24
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_56, Type: Literature]
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25
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_57, Type: Literature]
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26
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_58, Type: Literature]
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27
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_2, Type: Literature]
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28
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_3, Type: Literature]
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29
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_4, Type: Literature]
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30
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_6, Type: Literature]
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31
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_7, Type: Literature]
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32
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_8, Type: Literature]
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33
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_11, Type: Literature]
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34
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_12, Type: Literature]
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35
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_13, Type: Literature]
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36
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_14, Type: Literature]
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37
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_15, Type: Literature]
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38
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_16, Type: Literature]
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39
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_17, Type: Literature]
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40
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_18, Type: Literature]
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41
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_19, Type: Literature]
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42
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_20, Type: Literature]
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43
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_21, Type: Literature]
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44
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_23, Type: Literature]
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45
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_24, Type: Literature]
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46
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_26, Type: Literature]
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47
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_27, Type: Literature]
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48
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_29, Type: Literature]
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49
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_32, Type: Literature]
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50
[SID26757962]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_33, Type: Literature]
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