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Lobeline (CID 3945) - Compound BioActivity Data
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BioActivity Outcomes:
Active(17)
 
 
Inactive(717)
 
 
Inconclusive(4)
 
 
Unspecified(11)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
7TM GPCR Srsx(19)
 
 
 
alkPPc(12)
 
 
Bcl-2 like(11)
 
 
Tryp SPc(7)
 
 
BioAssay Types:
Screening(509)
 
 
 
 
 
Confirmatory(198)
 
 
 
 
 
Literature(25)
 
 
 
 
BioActivity Types:
Potency(142)
 
 
 
 
 
IC50(43)
 
 
 
Ki(12)
 
 
EC50(8)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 690    Data Row: 749   Total Pages: 15   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103177971]
Ki 0.004Displacement of [3H]nicotine from alpha4beta2 nAChR in rat brain homogenate by liquid scintillation spectrophotometry [AID459741, Type: Literature]
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2
[SID103177971]
Ki 0.12Inhibitory constant for cytochrome P450 2D6 [AID150609, Type: Literature]Cytochrome P450 2D6 [gi:84028191]
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3
[SID103177971]
Ki 0.47Inhibition of [3H]dopamine uptake at VMAT2 in rat brain synaptic vesicle by liquid scintillation spectroscopy [AID440783, Type: Literature]Synaptic vesicular amine transporter [gi:34978379]
View
4
[SID103177971]
Ki 2.76Inhibition of [3H]DTBZ binding to VMAT2 in rat synaptic vesicle membrane [AID271310, Type: Literature]Synaptic vesicular amine transporter [gi:34978379]
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5
[SID103177971]
Ki 2.76Displacement of [3H]DTBZ from VMAT2 dihydrotetrabenazine binding site in rat brain synaptic vesicle by scintillation counting [AID440782, Type: Literature]Synaptic vesicular amine transporter [gi:34978379]
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6
[SID103177971]
Ki 2.76Binding affinity to VMAT2 receptor [AID459752, Type: Literature]
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7
[SID103177971]
Ki 5.46Displacement of [3H]MTBZ from VMAT2 in rat whole brain vesicles by liquid scintillation spectrophotometry [AID459748, Type: Literature]Synaptic vesicular amine transporter [gi:34978379]
View
8
[SID103177971]
Ki 6.26Displacement of [3H]MLA from alpha7 nAChR in rat brain homogenate by liquid scintillation spectrophotometry [AID459740, Type: Literature]
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9
[SID16953570]
Potency 18.3564qHTS Assay for Lipid Storage Modulators in Drosophila S3 Cells [AID2685, Type: confirmatory]
View
10
[SID103177971]
Ki 28.2Inhibition of [3H]DA uptake at DAT in rat brain striatal synaptosomes by liquid scintillation spectrophotometry [AID459744, Type: Literature]Sodium-dependent dopamine transporter [gi:128613]
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11
[SID103177971]
Ki 28.2Inhibition of [3H]DA uptake at DAT in rat striatal synaptosomes [AID271308, Type: Literature]Sodium-dependent dopamine transporter [gi:128613]
View
12
[SID103177971]
Ki 46.8Inhibition of [3H]5-HT uptake at SERT in rat hippocampal synaptosomes [AID271309, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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13
[SID103177971]
Ki 46.8Inhibition of [3H]5HT uptake at SERT in rat brain hippocampal synaptosomes by liquid scintillation spectrophotometry [AID459745, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
View
14
[SID16953570]
Leishmania major promastigote HTS [AID1063, Type: screening]
View
15
[SID16953570]
High Content Assay for Compounds that inhibit the Assembly of the Perinucleolar Compartment [AID2417, Type: screening]polypyrimidine tract-binding protein 1 isoform a [Homo sapiens] [gi:4506243]
View
16
[SID16953570]
qHTS of D3 Dopamine Receptor Antagonist: qHTS [AID652054, Type: screening]D(3) dopamine receptor isoform e [Homo sapiens] [gi:89191863]
View
17
[SID103177971]
IC50 Inhibition of [3H]MLA binding to alpha-7 nAChR in rat brain membrane [AID271307, Type: Literature]Neuronal acetylcholine receptor subunit alpha-7 [gi:146345356]
View
18
[SID103177971]
Ratio of Ki for displacement of [3H]DTBZ from VMAT2 dihydrotetrabenazine binding site in rat brain synaptic vesicle to Ki for inhibition of [3H]dopamine uptake at VMAT2 in rat brain synaptic vesicle [AID440784, Type: Literature]Synaptic vesicular amine transporter [gi:34978379]
View
19
[SID16953570]
Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
View
20
[SID103177971]
Literature-mined public compounds from Kruhlak et al phospholipidosis modelling dataset [AID588220, Type: Literature]
View
21
[SID103177971]
Selectivity for VMAT2 over DAT [AID271311, Type: Literature]
View
22
[SID103177971]
Selectivity for VMAT2 over SERT [AID271312, Type: Literature]
View
23
[SID16953570]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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24
[SID103177971]
Selectivity ratio of Ki for rat VMAT2 to Ki for rat alpha4beta2 nAChR [AID459751, Type: Literature]
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25
[SID103177971]
Maximum percent of enhancement of binding. [AID30377, Type: Literature]
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26
[SID103177971]
Compounds was evaluated for their ability to enhance (+/-)-[3H]nicotine binding at a particular dose range 5E-9 - 1.5E-8 was reported [AID30529, Type: Literature]
View
27
[SID16953570]
Potency Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
View
28
[SID16953570]
Potency qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
View
29
[SID16953570]
Potency 2.5119qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium [AID1457, Type: confirmatory]Inositol monophosphatase 1 [gi:44888968]
View
30
[SID16953570]
Potency 89.1251qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). [AID588795, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
View
31
[SID16953570]
Fluorescence polarization-based counterscreen for RBBP9 inhibitors: primary biochemical high throughput screening assay to identify inhibitors of the oxidoreductase glutathione S-transferase omega 1(GSTO1). [AID1974, Type: screening]glutathione S-transferase omega-1 isoform 1 [Homo sapiens] [gi:4758484]
View
32
[SID16953570]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of human platelet activating factor acetylhydrolase 2 (PAFAH2) [AID492956, Type: screening]platelet-activating factor acetylhydrolase 2, cytoplasmic [Homo sapiens] [gi:4758878]
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33
[SID16953570]
Potency qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]ras-related protein Rab-9A [Homo sapiens] [gi:4759012]
View
34
[SID16953570]
uHTS identification of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assay [AID651636, Type: screening]G-protein coupled receptor 183 [Homo sapiens] [gi:4826706]
View
35
[SID16953570]
uHTS identification of inhibitors of MT1-MMP activation in a fluoresence assay [AID651647, Type: screening]matrix metalloproteinase-14 preproprotein [Homo sapiens] [gi:4826834]
View
36
[SID124812519]
A screen for small molecule inhibitors of the human deubiquitinating enzyme, UCH37 [AID588478, Type: other]ubiquitin C-terminal hydrolase UCH37 [Homo sapiens] [gi:4877999]
View
37
[SID16953570]
uHTS identification of small molecule agonists of the APJ receptor via a luminescent beta-arrestin assay [AID2520, Type: screening]apelin receptor [Homo sapiens] [gi:4885057]
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38
[SID16953570]
uHTS identification of small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay [AID2521, Type: screening]apelin receptor [Homo sapiens] [gi:4885057]
View
39
[SID16953570]
Luminescence-based primary cell-based high throughput screening assay to identify inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1) [AID504766, Type: screening]nuclear receptor subfamily 0 group B member 1 [Homo sapiens] [gi:5016090]
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40
[SID16953570]
Luminescence-based cell-based primary high throughput screening assay for inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1): repression of SF-1 (NR5A1) activated StAR promoter by full-length DAX-1 [AID652010, Type: screening]nuclear receptor subfamily 0 group B member 1 [Homo sapiens] [gi:5016090]
View
41
[SID16953570]
Potency qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation [AID540263, Type: confirmatory]snurportin-1 [Homo sapiens] [gi:5031833]
View
42
[SID16953570]
Potency qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation [AID540253, Type: confirmatory]snurportin-1 [Homo sapiens] [gi:5031833]
View
43
[SID16953570]
Primary cell-based high-throughput screening assay for identification of compounds that inhibit regulator of G-protein signaling 4 (RGS4) [AID463165, Type: screening]regulator of G-protein signaling 4 isoform 2 [Homo sapiens] [gi:5032039]
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44
[SID16953570]
Primary cell-based high-throughput screening assay for identification of compounds that potentiate/activate regulator of G-protein signaling 4 (RGS4) [AID463111, Type: screening]regulator of G-protein signaling 4 isoform 2 [Homo sapiens] [gi:5032039]
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45
[SID16953570]
EC50 uHTS luminescence assay for the identification of compounds that inhibit NOD1 [AID1578, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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46
[SID16953570]
Potency qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation [AID540253, Type: confirmatory]GTP-binding nuclear protein Ran [Homo sapiens] [gi:5453555]
View
47
[SID16953570]
Counterscreen for PME1 inhibitors: fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of lysophospholipase 1 (LYPLA1). [AID2174, Type: screening]acyl-protein thioesterase 1 isoform 1 [Homo sapiens] [gi:5453722]
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48
[SID16953570]
Potency qHTS Assay to Find Inhibitors of Pin1 [AID504891, Type: confirmatory]peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [Homo sapiens] [gi:5453898]
View
49
[SID16953570]
ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_SinglePoint_HTS_Activity [AID623870, Type: screening]transforming acidic coiled-coil-containing protein 3 [Homo sapiens] [gi:5454102]
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50
[SID16953570]
Potency qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101 [AID493005, Type: confirmatory]tumor susceptibility gene 101 protein [Homo sapiens] [gi:5454140]
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