Ritonavir (CID 392622) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(214)
 
 
Inactive(356)
 
 
Inconclusive(15)
 
 
Unspecified(491)
 
 
Top Targets:
7TM GPCR Srx(22)
 
 
 
 
p450(21)
 
 
 
7TM GPCR Srsx(12)
 
 
 
alkPPc(10)
 
 
Bcl-2 like(10)
 
 
BioAssay Types:
Literature(522)
 
 
 
 
 
Screening(213)
 
 
 
 
Confirmatory(147)
 
 
 
 
BioActivity Types:
IC50(197)
 
 
 
 
EC50(143)
 
 
 
 
 
Potency(100)
 
 
 
 
Ki(25)
 
 
 
Kd(3)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1037    Data Row: 1076   Total Pages: 22   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103244854]
Ki 1.5e-05Inhibition constant of ritonavir towards HIV protease was determined [AID82914, Type: other]
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2
[SID103244854]
Ki 1.5e-05Tested for inhibitor binding of wild-type HIV PR [AID82946, Type: Literature]
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3
[SID103244854]
Ki 2e-05Inhibitory activity against purified HIV protease [AID82795, Type: other]
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4
[SID103244854]
Ki 2e-05Inhibition of HIV protease [AID160300, Type: Literature]Pol polyprotein [gi:75593047]
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5
[SID103244854]
Ki 3.4e-05Inhibition of HIV1 protease [AID374591, Type: Literature]
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6
[SID103244854]
EC50 5.5e-05The activity against mutant HIV molecular clone wt (pNL4-3) was determined [AID82723, Type: other]
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7
[SID103244854]
Ki 6.2e-05Dissociation constant obtained by inhibition of Wild-type protease [AID219260, Type: Literature]
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8
[SID103244854]
Ki 9.8e-05Inhibition of HIV1 protease [AID321660, Type: Literature]
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9
[SID103244854]
Ki 0.00012Tested for inhibitor binding of D25N/V82A mutant of HIV PR [AID82944, Type: Literature]
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10
[SID103244854]
EC50 0.00023The activity against mutant HIV molecular clone V82A was determined [AID82600, Type: other]
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11
[SID103244854]
EC50 0.000308The activity against mutant HIV molecular clone V82F was determined [AID82601, Type: other]
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12
[SID103244854]
EC50 0.000316The activity against mutant HIV molecular clone V82T was determined [AID82602, Type: other]
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13
[SID103244854]
Ki 0.00037Binding affinity to inhibit the purified wild-type HIV-1 Protease [AID160316, Type: Literature]Pol polyprotein [gi:75593047]
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14
[SID103244854]
Ki 0.00037Binding affinity for HIV -1 Protease [AID82295, Type: Literature]Pol polyprotein [gi:75593047]
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15
[SID103244854]
Ki 0.00037Affinity against HIV protease [AID162710, Type: Literature]Pol polyprotein [gi:75593047]
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16
[SID103244854]
Ki 0.00037Inhibitory activity against HIV-1 protease [AID163487, Type: Literature]Pol polyprotein [gi:75593047]
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17
[SID103244854]
Ki 0.00046Inhibition of HIV1 Protease M2 variant by FRET based assay [AID297669, Type: Literature]
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18
[SID103244854]
Ki 0.00059Inhibition constant for human immunodeficiency virus type 1 protease [AID238682, Type: Literature]
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19
[SID103244854]
Ki 0.00059Inhibition constant against HIV-1 Protease [AID160455, Type: Literature]Pol polyprotein [gi:75593047]
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20
[SID103244854]
Kd 0.0006Binding affinity for human immunodeficiency virus type 1 protease [AID238043, Type: Literature]
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21
[SID103244854]
Kd 0.000608Equilibrium constant for the interaction between inhibitor and HIV-1 Protease [AID162706, Type: Literature]Pol polyprotein [gi:75593047]
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22
[SID103244854]
Ki 0.0008Inhibition of HIV1 protease expressed in Escherichia coli by fluorometric assay [AID443165, Type: Literature]
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23
[SID103244854]
Ki 0.00082Inhibitory concentration against HIV-1 protease [AID160481, Type: Literature]Pol polyprotein [gi:75593047]
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24
[SID103244854]
EC50 0.0015Antiviral activity against wild type HIV1 3B infected in human MT4 LTR-EGFP cells by EGFP reporter gene assay [AID671806, Type: Literature]
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25
[SID103244854]
EC50 0.002Antiviral activity against HIV1 3B [AID321661, Type: Literature]
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26
[SID103244854]
Ki 0.00281Inhibition of HIV1 Protease M3 variant by FRET based assay [AID297670, Type: Literature]
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27
[SID103244854]
Ki 0.00303Inhibition of HIV1 Protease M1 variant by FRET based assay [AID297668, Type: Literature]
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28
[SID103244854]
EC50 0.005The activity against HIV was determined from patient number 129 [AID82594, Type: other]
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29
[SID103244854]
IC50 0.01Inhibitory concentration of compound against HIV LAI in MT-2 cells when tested at a range of 0.001-10 uM concentration [AID248602, Type: Literature]
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30
[SID103244854]
IC50 0.01Inhibitory concentration of compound against HIV LAI in MT-4 cells when tested at a range of 0.001-10 uM concentration [AID248603, Type: Literature]
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31
[SID103244854]
IC50 0.015Antiviral activity against multi drug-resistant HIV1 ET variant in human PHA-PBMC cells [AID269310, Type: Literature]
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32
[SID103244854]
EC50 0.016Antiviral activity against nelfinavir-resistant HIV1 NL432 [AID290999, Type: Literature]
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33
[SID103244854]
EC50 0.016Antiviral activity against wild type HIV1 [AID321685, Type: Literature]
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34
[SID103244854]
EC50 0.016Antiviral activity against nelfinavir-resistant HIV1 NL432 [AID408211, Type: Literature]
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35
[SID103244854]
IC50 0.016DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625248, Type: other]Cytochrome P450 2C9 [gi:6686268]
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36
[SID103244854]
IC50 0.016DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625248, Type: other]Cytochrome P450 2C9 [gi:6686268]
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37
[SID103244854]
IC50 0.016DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625248, Type: other]Cytochrome P450 2C9 [gi:6686268]
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38
[SID103244854]
IC50 0.016DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) [AID625251, Type: other]Cytochrome P450 3A4 [gi:116241312]
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39
[SID103244854]
IC50 0.016DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) [AID625251, Type: other]Cytochrome P450 3A4 [gi:116241312]
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40
[SID103244854]
IC50 0.016DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) [AID625251, Type: other]Cytochrome P450 3A4 [gi:116241312]
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41
[SID103244854]
EC50 0.019The activity against HIV was determined from patient number 304 [AID82596, Type: other]
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42
[SID103244854]
EC50 0.021Antiviral activity against HIV1 NL4-3 infected in human MT4 cells assessed as inhibition of p24 gag protein production by ELISA [AID557284, Type: Literature]
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43
[SID103244854]
EC50 0.022Anti-HIV activity against MT-4 cells using a cytopathicity assay [AID105177, Type: other]
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44
[SID103244854]
EC50 0.022Antiviral activity against HIV1 in the absence of human serum [AID257270, Type: Literature]
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45
[SID103244854]
Ki 0.023Dissociation constant obtained by inhibition of mutant HIV-protease (V-18) [AID225564, Type: Literature]
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46
[SID103244854]
EC50 0.023The activity against HIV strain was determined from patient number 302 [AID82593, Type: other]
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47
[SID103244854]
EC50 0.023Antiviral activity against HIV1 BaL R5 subtype B in phytohemagglutinin-activated PBMCs assessed as inhibition of p24 Gag protein expression by MTT assay [AID322121, Type: Literature]
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48
[SID103244854]
EC50 0.024Antiviral activity against HIV1 3B in presence of 10% fetal calf serum [AID408214, Type: Literature]
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49
[SID103244854]
EC50 0.025Antiviral activity against wild type HIV1 ERS104prc X4 in phytohemagglutinin-activated PBMCs assessed as inhibition of p24 Gag protein expression by MTT assay [AID322112, Type: Literature]
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50
[SID103244854]
EC50 0.03Antiviral activity against HIV1 92TH019 R5 subtype E in phytohemagglutinin-activated PBMCs assessed as inhibition of p24 Gag protein expression by MTT assay [AID322123, Type: Literature]
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