Nordefrin (CID 3917) - BioAssay Data Summary for Compound
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BioActivity Outcomes:
Active(9)
 
 
Top Targets:
7TM GPCR Srx(1)
 
 
Ape1-like AP-..(1)
 
 
HELICc(1)
 
 
JmjC(1)
 
 
PolY Pol IV k..(1)
 
 
BioAssay Types:
Confirmatory(7)
 
 
Literature(1)
 
 
BioActivity Types:
Potency(7)
 
 
Ki(1)
 
 
SAR
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 9    Data Row: 9   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103203245]
Ki 0.0077Displacement of [3H]clonidine from Alpha-2 adrenergic receptor of rat brain membranes [AID35187, Type: Literature]Alpha-2A adrenergic receptor [gi:231461]
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2
[SID26748104]
Potency 1.4125qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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3
[SID124879888]
Potency 3.1623qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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4
[SID124879888]
Potency 3.1623qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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5
[SID26748104]
Potency 7.0795qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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6
[SID26748104]
Potency 7.0795qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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7
[SID26748104]
Potency 7.9433qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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8
[SID26748104]
Potency 7.9433qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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9
[SID26748104]
Potency 14.1254Counterscreen for RECQ1 Inhibitors: ADP Fluorescence Polarization Displacement Assay [AID2711, Type: confirmatory]
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10
[SID26748104]
Potency 14.1254Counterscreen for BLMA Inhibitors: ADP Fluorescence Polarization Displacement Assay [AID2712, Type: confirmatory]
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11
[SID85209364]
 Ligands of bioamine (Class A) GPCRs [AID2062, Type: other]
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