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Bezafibrate (CID 39042) - Compound BioActivity Data
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BioActivity Outcomes:
Active(23)
 
 
Inactive(1476)
 
 
Inconclusive(58)
 
 
Unspecified(1120)
 
 
Top Targets:
7tm 4(86)
 
 
 
NR LBD PPAR(56)
 
 
 
 
 
p450(23)
 
 
 
 
NR LBD ER(21)
 
 
 
NR LBD TR(20)
 
 
BioAssay Types:
Confirmatory(800)
 
 
 
 
 
Screening(623)
 
 
 
Literature(219)
 
 
 
 
 
Summary(48)
 
 
 
 
BioActivity Types:
Potency(615)
 
 
 
 
 
IC50(162)
 
 
 
EC50(48)
 
 
 
 
Ki(4)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2186    Data Row: 2677   Total Pages: 134   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103216609]
EC50 1.04Transactivation of PPAR transfected in human HepG2 cells after 20 hrs by luciferase reporter gene assay [AID696365, Type: Literature]
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2
[SID103216609]
EC50 1.05Transactivation of PPAR expressed in HepG2 cells after 20 hrs by luminescence assay [AID655420, Type: Literature]
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3
[SID103216609]
EC50 3Agonist activity at human PPARgamma expressed in CV1 cells by transactivation assay [AID320687, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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4
[SID103216609]
EC50 18.9Agonist activity at human PPARdelta expressed in HepG2 cells co-transfected with PPRE3-TK-luc assessed as beta-galactosidase activity after 20 to 22 hrs by luciferase based transactivation assay [AID552401, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
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5
[SID103216609]
EC50 20Agonist activity for Human PPAR delta receptor in transcriptional activation assay [AID91241, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
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6
[SID103216609]
EC50 20Compound was tested for agonist activity on human Peroxisome proliferator activated receptor delta-GAL4 chimeric receptor in transfected CV-1 cells [AID156469, Type: Literature]
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7
[SID144212162]
Ratio Potency (uM) 21.8724qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway: Summary [AID743140, Type: summary]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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8
[SID170465743]
Ratio Potency (uM) 28.7233qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway: Summary [AID743227, Type: summary]peroxisome proliferator-activated receptor delta [Homo sapiens] [gi:216409690]
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9
[SID103216609]
EC50 30Agonist activity at human PPARalpha expressed in monkey CV1 cells by transactivation assay [AID318247, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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10
[SID103216609]
EC50 30Agonist activity at human PPARalpha expressed in CV1 cells by transactivation assay [AID320686, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
11
[SID103216609]
EC50 30Agonist activity at human PPARdelta expressed in monkey CV1 cells by transactivation assay [AID318249, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
12
[SID103216609]
EC50 30Agonist activity at human PPARdelta expressed in CV1 cells by transactivation assay [AID320688, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
13
[SID103216609]
Ki 33Displacement of 1-anilinonaphthalene-8-sulphonic acid from I-FABP [AID407368, Type: Literature]
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14
[SID103216609]
EC50 35.7In vitro transactivation using receptor transactivation assay against hPPAR alpha [AID223541, Type: Literature]
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15
[SID103216609]
EC50 35.74Agonist activity at human PPARdelta expressed in HEK293 cells cotransfected with PPREx4-TK-luc assessed as activation of luciferase activity measured after 48 hrs by transactivation assay [AID736342, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
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16
[SID144212162]
Potency-Replicate_1 38.8952qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway [AID743212, Type: confirmatory]peroxisome proliferator-activated receptor delta [Homo sapiens] [gi:216409690]
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17
[SID144212162]
Ratio Potency (uM) 41.1999qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway: Summary [AID743227, Type: summary]peroxisome proliferator-activated receptor delta [Homo sapiens] [gi:216409690]
View
18
[SID103216609]
EC50 42.5Agonist activity at human PPARalpha expressed in HepG2 cells co-transfected with PPRE3-TK-luc assessed as beta-galactosidase activity after 20 to 22 hrs by luciferase based transactivation assay [AID552193, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
19
[SID103216609]
Ki 44.4Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP low binding affinity site expressed in Escherichia coli BL21 by competitive fluorescence displacement assay [AID407369, Type: Literature]Fatty acid-binding protein, liver [gi:119810]
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20
[SID103216609]
EC50 46.58Agonist activity at human PPARalpha expressed in HEK293 cells cotransfected with PPREx4-TK-luc assessed as activation of luciferase activity measured after 48 hrs by transactivation assay [AID736344, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View