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lamotrigine (CID 3878) - Compound BioActivity Data
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BioActivity Outcomes:
Active(71)
 
 
Inactive(1540)
 
 
Inconclusive(42)
 
 
Unspecified(493)
 
 
Top Targets:
Na trans asso..(67)
 
 
 
7TM GPCR Srx(58)
 
 
 
 
7TM GPCR Srsx(44)
 
 
 
p450(28)
 
 
 
 
Bcl-2 like(20)
 
 
BioAssay Types:
Confirmatory(815)
 
 
 
 
 
Screening(710)
 
 
 
 
Literature(348)
 
 
 
 
 
Summary(25)
 
 
 
BioActivity Types:
Potency(558)
 
 
 
 
 
IC50(219)
 
 
 
 
 
EC50(20)
 
 
Ki(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1558    Data Row: 2146   Total Pages: 108   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103199382]
IC50 2.6Displacement of [3H]BW202W92 from voltage-gated sodium channel in Wistar rat forebrain synaptosomes by liquid scintillation counting [AID352884, Type: Literature]
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2
[SID11113342]
Potency 6.3096qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6 [AID891, Type: confirmatory]cytochrome P450 2D6 isoform 1 [Homo sapiens] [gi:40805836]
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3
[SID103199382]
IC50 8.1Inhibition of human aquaporin 4 M23 isoform expressed in Xenopus laevis oocytes [AID409601, Type: Literature]
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4
[SID103199382]
IC50 10Inhibition of human recombinant Nav1.2 channel expressed in HEK293 cells by whole cell voltage clamp technique [AID404535, Type: Literature]Sodium channel protein type 2 subunit alpha [gi:25014053]
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5
[SID103199382]
Ki 17Affinity for inactive human SkM1 sodium channel expressed in HEK293 cells [AID205290, Type: Literature]Sodium channel protein type 4 subunit alpha [gi:292495096]
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6
[SID90341162]
Potency 20.5962qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
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7
[SID103199382]
IC50 21Inhibition of veratridine-induced guanidine flux in cardiac voltage-gated sodium channel (veratridine block vs. Na release) [AID217929, Type: Literature]
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8
[SID103199382]
IC50 25Blockade of Nav1.8 channel in rat dorsal root ganglion neurons assessed as inhibition of TTX-R current by whole cell patch clamp technique [AID404533, Type: Literature]Sodium channel protein type 10 subunit alpha [gi:56748617]
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9
[SID855818]
IC50 25.82A counter screen for small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID2384, Type: confirmatory]
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10
[SID103199382]
Ki 29.2Dissociation constant for binding to inactivated state of rat brain NaIIa (rNav1.2) -B2 cell line stably expressed in HEK293 Cells [AID244602, Type: Literature]
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11
[SID103199382]
IC50 31Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brain [AID205273, Type: Literature]Sodium channel protein type 1 subunit alpha [gi:116447]
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12
[SID103199382]
IC50 31Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brain [AID205273, Type: Literature]Sodium channel protein type 2 subunit alpha [gi:116448]
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13
[SID103199382]
IC50 31Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brain [AID205273, Type: Literature]Sodium channel protein type 3 subunit alpha [gi:116449]
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14
[SID855818]
IC50 32.987A screen for inhibitors of the PhoP regulon in Salmonella Typhi using a modified counterscreen [AID1985, Type: confirmatory]
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15
[SID103199382]
IC50 35Inhibition of rat Nav1.2 channel expressed in chinese hamster CHL1610 cells at preconditioning pulse of -67 mV after 2 to 3 mins by whole-cell patch-clamp technique [AID471864, Type: Literature]Sodium channel protein type 2 subunit alpha [gi:116448]
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16
[SID103199382]
IC50 35Inhibition of rat Nav1.2 expressed in CHL1610 cells at -67 to -107 mV after 2 to 3 mins by whole-cell patch-clamp assay [AID1058310, Type: Literature]Sodium channel protein type 2 subunit alpha [gi:116448]
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17
[SID855818]
IC50 60.49A Counter Screen to identiry small molecule screen for inhibitors of the PhoP regulon in Salmonella Typhimurium [AID2401, Type: confirmatory]
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18
[SID855818]
IC50 65.34A small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID1850, Type: confirmatory]
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19
[SID855818]
IC50 66.35A screen for inhibitors of the PhoP regulon in Salmonella Typhimurium using a modified counterscreen. [AID1981, Type: confirmatory]
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20
[SID855818]
IC50 150A small molecule screen for inhibitors of the PhoP regulon in Salmonella Typhimurium [AID1863, Type: confirmatory]
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