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BioActivity Data for Compound bortezomib (CID 387447)

BioActivity Outcomes:
Active(940)
 
 
Inactive(148)
 
 
Inconclusive(59)
 
 
Unspecified(720)
 
 
Top Targets:
proteasome be..(59)
 
 
 
proteasome be..(22)
 
 
proteasome be..(22)
 
 
proteasome al..(22)
 
 
Tryp SPc(21)
 
 
 
 
BioAssay Types:
Confirmatory(625)
 
 
 
 
 
Literature(593)
 
 
 
 
Summary(44)
 
 
 
 
Screening(17)
 
 
 
BioAssay Categories:
In vitro(362)
 
 
 
In vivo(536)
 
 
Biochemical(354)
 
 
 
 
Toxicity(588)
 
 
 
 
ADME(89)
 
 
 
Cell-based(586)
 
 
 
 
BioActivity Types:
IC50(574)
 
 
 
 
Potency(188)
 
 
 
 
Ki(19)
 
 
 
AC50(12)
 
 
 
EC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1597    Data Row: 1867   Total Pages: 94   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103338073]
IC50 2.1e-06SANGER: Inhibition of human ES6 cell growth in a cell viability assay. [AID742150, Type: confirmatory]
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2
[SID103338073]
IC50 0.000161Inhibition of chymotrypsin-like activity of mouse liver 20S proteasome [AID452098, Type: Literature]
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3
[SID103338073]
IC50 0.000163SANGER: Inhibition of human SK-UT-1 cell growth in a cell viability assay. [AID741882, Type: confirmatory]
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4
[SID103338073]
IC50 0.000173SANGER: Inhibition of human SH-4 cell growth in a cell viability assay. [AID741856, Type: confirmatory]
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5
[SID103338073]
IC50 0.000182SANGER: Inhibition of human TE-9 cell growth in a cell viability assay. [AID742018, Type: confirmatory]
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6
[SID103338073]
IC50 0.0002Inhibition of chymotrypsin-like activity of 20S proteasome in human DLD1 cells transfected with 4Ub-Luc gene using Succinyl-Leu-Leu-Val-Tyr-AMC as substrate after 6 hrs by spectrofluorometric analysis [AID640521, Type: Literature]
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7
[SID103338073]
IC50 0.000208SANGER: Inhibition of human A253 cell growth in a cell viability assay. [AID741945, Type: confirmatory]
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8
[SID103338073]
IC50 0.00021SANGER: Inhibition of human no-10 cell growth in a cell viability assay. [AID742052, Type: confirmatory]
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9
[SID103338073]
IC50 0.000216SANGER: Inhibition of human MMAC-SF cell growth in a cell viability assay. [AID742370, Type: confirmatory]
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10
[SID103338073]
IC50 0.000225SANGER: Inhibition of human A101D cell growth in a cell viability assay. [AID741941, Type: confirmatory]
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11
[SID103338073]
GI50 0.00023Growth inhibition of human RPMI8226 cells [AID1156360, Type: Literature]
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12
[SID103338073]
IC50 0.000243SANGER: Inhibition of human NTERA-S-cl-D1 cell growth in a cell viability assay. [AID741784, Type: confirmatory]
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13
[SID103338073]
IC50 0.00025SANGER: Inhibition of human 8-MG-BA cell growth in a cell viability assay. [AID741938, Type: confirmatory]
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14
[SID103338073]
IC50 0.000258SANGER: Inhibition of human KNS-42 cell growth in a cell viability assay. [AID742277, Type: confirmatory]
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15
[SID103338073]
IC50 0.000269SANGER: Inhibition of human LXF-289 cell growth in a cell viability assay. [AID742333, Type: confirmatory]
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16
[SID103338073]
IC50 0.000289SANGER: Inhibition of human OVCAR-4 cell growth in a cell viability assay. [AID741799, Type: confirmatory]
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17
[SID103338073]
IC50 0.000293SANGER: Inhibition of human LOUCY cell growth in a cell viability assay. [AID742320, Type: confirmatory]
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18
[SID103338073]
IC50 0.000304SANGER: Inhibition of human BB65-RCC cell growth in a cell viability assay. [AID741971, Type: confirmatory]
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19
[SID103338073]
IC50 0.000329SANGER: Inhibition of human D-542MG cell growth in a cell viability assay. [AID742108, Type: confirmatory]
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20
[SID103338073]
IC50 0.00033SANGER: Inhibition of human ONS-76 cell growth in a cell viability assay. [AID741795, Type: confirmatory]
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