juglone (CID 3806) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(58)
 
 
Inactive(71)
 
 
Inconclusive(46)
 
 
Unspecified(36)
 
 
Top Targets:
HELICc(5)
 
 
Menin(4)
 
 
NR LBD ROR li..(4)
 
 
 
NR LBD TR(4)
 
 
 
PolY Pol IV k..(4)
 
 
BioAssay Types:
Confirmatory(88)
 
 
 
 
Literature(48)
 
 
 
 
Screening(12)
 
 
 
BioActivity Types:
Potency(85)
 
 
 
 
IC50(9)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 183    Data Row: 211   Total Pages: 5   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26749198]
Potency 0.3162qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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2
[SID26753750]
Potency 0.631qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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3
[SID26753750]
Potency 0.631qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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4
[SID26749198]
Potency 0.7943qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta- Hydroxysteroid Dehydrogenase Type 10) Bound [gi:122921310]
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5
[SID103222861]
IC50 0.8Antiproliferative (inhibition of cell growth) activity against HaCaT cells (human keratinocyte line) [AID85482, Type: Literature]
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6
[SID103222861]
IC50 1Inhibition of purified human recombinant IDO [AID326467, Type: Literature]Indoleamine 2,3-dioxygenase 1 [gi:123948]
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7
[SID103222861]
IC50 1.4Antiproliferative activity against human A2780 cells after 2 days by alamar-blue assay [AID417089, Type: Literature]
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8
[SID26749198]
Potency 1.7783qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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9
[SID103222861]
IC50 1.98Inhibition of histidine-tagged human recombinant Cdc25B catalytic domain expressed in Escherichia coli [AID417086, Type: Literature]M-phase inducer phosphatase 2 [gi:21264471]
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10
[SID103222861]
IC50 1.98Inhibition of histidine-tagged human recombinant Cdc25B catalytic domain expressed in Escherichia coli [AID417086, Type: Literature]M-phase inducer phosphatase 2 [gi:21264471]
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11
[SID26749198]
Potency 1.9953qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase) [AID887, Type: confirmatory]15-lipoxygenase [Homo sapiens] [gi:1832253]
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12
[SID26749198]
Potency 1.9953qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase) [AID887, Type: confirmatory]15-lipoxygenase [Homo sapiens] [gi:1832253]
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13
[SID26753750]
Potency 1.9953qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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14
[SID26749198]
Potency 2.2387qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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15
[SID26749198]
Potency 2.2387qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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16
[SID26753750]
Potency 2.6679qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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17
[SID26753750]
Potency 2.6679qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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18
[SID26749198]
Potency 3.1623qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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19
[SID26749198]
Potency 3.1623qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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20
[SID26749198]
Potency 3.1623qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2) [AID881, Type: confirmatory]Arachidonate 15-lipoxygenase B [gi:317373425]
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21
[SID26749198]
Potency 3.1623qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2528, Type: confirmatory]Bloom syndrome protein [Homo sapiens] [gi:4557365]
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22
[SID103222861]
IC50 3.7In vitro antimalarial activity against human malaria parasite, P falciparum (Vietnam Smith strain) [AID152094, Type: Literature]
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23
[SID26753750]
Potency 4.4668qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: Hit Validation [AID504374, Type: confirmatory]core-binding factor subunit beta isoform 2 [Homo sapiens] [gi:13124873]
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24
[SID26753750]
Potency 4.4668qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: Hit Validation [AID504374, Type: confirmatory]core-binding factor subunit beta isoform 2 [Homo sapiens] [gi:13124873]
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25
[SID26753750]
Potency 4.4668qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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26
[SID103222861]
MIC 5Inhibition of topoisomerase I [AID228426, Type: Literature]
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27
[SID26753750]
Potency 5.6234qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2528, Type: confirmatory]Bloom syndrome protein [Homo sapiens] [gi:4557365]
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28
[SID26749198]
Potency 7.0795qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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29
[SID26749198]
Potency 7.0795Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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30
[SID26749198]
Potency 7.9433qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent) [AID1476, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
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31
[SID26749198]
Potency 7.9433Confirmation qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2708, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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32
[SID26749198]
Potency 8.9125Inhibitors of USP1/UAF1: Pilot qHTS [AID504865, Type: confirmatory]USP1 protein [Homo sapiens] [gi:118600387]
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33
[SID26753750]
Potency 8.9125Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1479, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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34
[SID26753750]
Potency 8.9125Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1479, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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35
[SID26753750]
Potency 8.9125Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1479, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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36
[SID26749198]
Potency 10Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1479, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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37
[SID26749198]
Potency 10Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1479, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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38
[SID26749198]
Potency 10Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1479, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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39
[SID26749198]
Potency 11.2202qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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40
[SID26749198]
Potency 11.2202qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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41
[SID103222861]
IC50 12.4Inhibition of histidine-tagged rat recombinant MKP3 catalytic domain expressed in Escherichia coli BL21(DE3) [AID417088, Type: Literature]Dual specificity protein phosphatase 6 [gi:2499748]
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42
[SID103222861]
IC50 12.4Inhibition of histidine-tagged rat recombinant MKP3 catalytic domain expressed in Escherichia coli BL21(DE3) [AID417088, Type: Literature]Dual specificity protein phosphatase 6 [gi:2499748]
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43
[SID26749198]
Potency 12.5893qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a [AID927, Type: confirmatory]ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] [gi:188528692]
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44
[SID26749198]
Potency 12.5893qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a [AID927, Type: confirmatory]ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] [gi:188528692]
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45
[SID26749198]
Potency 12.5893qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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46
[SID26749198]
Potency 12.5893qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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47
[SID103222861]
IC50 13Inhibition of histidine-tagged mouse MKP1 catalytic domain expressed in human Hela cells [AID417087, Type: Literature]Dual specificity protein phosphatase 1 [gi:136027]
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48
[SID26749198]
Potency 14.1254qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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49
[SID26749198]
Potency 14.1254qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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50
[SID26749198]
Potency 14.1254qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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