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juglone (CID 3806) - Compound BioActivity Data
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BioActivity Outcomes:
Active(99)
 
 
Inactive(86)
 
 
Inconclusive(53)
 
 
Unspecified(60)
 
 
Top Targets:
HELICc(5)
 
 
Bromo ALL-1(4)
 
 
NR LBD ROR li..(4)
 
 
 
NR LBD TR(4)
 
 
 
PolY Pol IV k..(4)
 
 
BioAssay Types:
Literature(123)
 
 
 
 
Confirmatory(104)
 
 
 
 
 
Screening(14)
 
 
 
BioActivity Types:
Potency(99)
 
 
 
 
IC50(14)
 
 
 
Ki(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 253    Data Row: 298   Total Pages: 15   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26749198]
Potency 0.3162qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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2
[SID26753750]
Potency 0.631qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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3
[SID26749198]
Potency 0.7943qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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4
[SID26749198]
Potency 0.7943qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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5
[SID103222861]
IC50 0.8Antiproliferative (inhibition of cell growth) activity against HaCaT cells (human keratinocyte line) [AID85482, Type: Literature]
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6
[SID103222861]
IC50 1Inhibition of purified human recombinant IDO [AID326467, Type: Literature]Indoleamine 2,3-dioxygenase 1 [gi:123948]
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7
[SID103222861]
IC50 1.4Antiproliferative activity against human A2780 cells after 2 days by alamar-blue assay [AID417089, Type: Literature]
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8
[SID26749198]
Potency 1.7783qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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9
[SID103222861]
IC50 1.98Inhibition of histidine-tagged human recombinant Cdc25B catalytic domain expressed in Escherichia coli [AID417086, Type: Literature]M-phase inducer phosphatase 2 [gi:21264471]
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10
[SID26749198]
Potency 1.9953qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase) [AID887, Type: confirmatory]15-lipoxygenase, partial [Homo sapiens] [gi:1832253]
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11
[SID26749198]
Potency 2.2387qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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12
[SID26753750]
Potency 2.6679qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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13
[SID26749198]
Potency 3.1623qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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14
[SID26749198]
Potency 3.1623qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2528, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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15
[SID26749198]
Potency 3.1623qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2) [AID881, Type: confirmatory]Arachidonate 15-lipoxygenase B [gi:317373425]
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16
[SID103222861]
IC50 3.7In vitro antimalarial activity against human malaria parasite, P falciparum (Vietnam Smith strain) [AID152094, Type: Literature]
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17
[SID26753750]
Potency 4.4668qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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18
[SID26753750]
Potency 4.4668qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: Hit Validation [AID504374, Type: confirmatory]core-binding factor subunit beta isoform 2 [Homo sapiens] [gi:13124873]
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19
[SID26753750]
Potency 4.4668qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: Hit Validation [AID504374, Type: confirmatory]runt-related transcription factor 1 isoform AML1b [Homo sapiens] [gi:49574546]
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20
[SID26753750]
Potency 5.6234qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2528, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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