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isovelleral (CID 37839) - Compound BioActivity Data
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BioActivity Outcomes:
Active(115)
 
 
Inactive(622)
 
 
Inconclusive(39)
 
 
Unspecified(5)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
 
7TM GPCR Srsx(22)
 
 
 
 
Bcl-2 like(11)
 
 
alkPPc(10)
 
 
ANK(9)
 
 
 
 
 
BioAssay Types:
Screening(515)
 
 
 
 
Confirmatory(234)
 
 
 
 
 
Literature(14)
 
 
 
 
BioActivity Types:
Potency(152)
 
 
 
 
 
IC50(48)
 
 
 
 
EC50(24)
 
 
 
 
 
AC50(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 711    Data Row: 781   Total Pages: 40   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID14719329]
IC50 0.253Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4) [AID1692, Type: confirmatory]Sphingosine-1-phosphate receptor 4 [Homo sapiens] [gi:15929025]
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2
[SID14719329]
EC50 0.5Image-based HTS for Selective Agonists of GPR55 [AID1961, Type: confirmatory]G-protein coupled receptor 55 [Homo sapiens] [gi:33695107]
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3
[SID14719329]
EC50 0.53Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) [AID2382, Type: confirmatory]Hsf1 protein [Mus musculus] [gi:62740231]
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4
[SID103616087]
EC50 0.59Agonist activity at human TRPA1 channel expressed in HEK293 cells assessed as increase in intracellular calcium influx [AID482143, Type: Literature]Transient receptor potential cation channel subfamily A member 1 [gi:313104269]
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5
[SID14719329]
Potency 0.8199qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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6
[SID14719329]
Absolute IC50 (CHOP) 0.85CHOP dose-response primary assay [AID504322, Type: confirmatory]DNA damage-inducible transcript 3 protein [Mus musculus] [gi:160707929]
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7
[SID14719329]
EC50_MICROM 0.865Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 based on MLPCN hits [AID2745, Type: confirmatory]LAP4 [Saccharomyces cerevisiae] [gi:486173]
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8
[SID14719329]
Potency 0.92qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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9
[SID14719329]
Potency 1.122VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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10
[SID14719329]
EC50_MICROM 1.264Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically MEP2 based on MLPCN hits [AID2742, Type: confirmatory]MEP2 [Saccharomyces cerevisiae] [gi:1302091]
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11
[SID14719329]
Potency 1.4125qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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12
[SID14719329]
EC50_MICROM 1.413Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically CIT2 based on MLPCN hits [AID2744, Type: confirmatory]citrate synthase 2, partial [Saccharomyces cerevisiae] [gi:171229]
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13
[SID14719329]
Potency 2.0596A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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14
[SID14719329]
Potency 2.2387qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase-type plasminogen activator precursor [Mus musculus] [gi:6679377]
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15
[SID14719329]
Potency 2.2387qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase plasminogen activator surface receptor precursor [Mus musculus] [gi:7242179]
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16
[SID14719329]
Potency 2.2387qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]plasminogen precursor [Mus musculus] [gi:257471003]
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17
[SID14719329]
Absolute IC50 (XBP1) 2.35XBP1 DR counterscreen for CHOP [AID504313, Type: confirmatory]XBP1 [Homo sapiens] [gi:47678753]
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18
[SID103616087]
EC50 2.58Agonist activity at mouse TRPA1 channel expressed in HEK293 cells assessed as increase in intracellular calcium influx [AID482144, Type: Literature]Transient receptor potential cation channel subfamily A member 1 [gi:56749781]
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19
[SID14719329]
IC50 2.94Elucidation of physiology of non-replicating, drug-tolerant Mycobacterium tuberculosis [AID488890, Type: confirmatory]
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20
[SID14719329]
Potency 3.1623qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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