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Isoproterenol (CID 3779) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(110)
 
 
Inactive(245)
 
 
Inconclusive(52)
 
 
Unspecified(309)
 
 
Top Targets:
7TM GPCR Srsx(81)
 
 
 
 
7TM GPCR Srx(42)
 
 
 
 
p450(10)
 
 
 
NR LBD ER(9)
 
 
 
 
NR LBD PPAR(8)
 
 
 
BioAssay Types:
Literature(352)
 
 
 
 
 
Confirmatory(187)
 
 
 
 
Summary(24)
 
 
 
Screening(2)
 
 
BioActivity Types:
Potency(203)
 
 
 
 
IC50(128)
 
 
 
EC50(65)
 
 
 
Ki(11)
 
 
Kd(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 630    Data Row: 716   Total Pages: 15   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID104234147]
EC50 8.4e-05Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation [AID366404, Type: Literature]Beta-1 adrenergic receptor [gi:48429211]
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2
[SID104234147]
EC50 8.4e-05Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation [AID387246, Type: Literature]Beta-1 adrenergic receptor [gi:48429211]
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3
[SID104234147]
EC50 8.4e-05Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor [AID246460, Type: Literature]Beta-1 adrenergic receptor [gi:48429211]
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4
[SID104234147]
EC50 8.4e-05Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA [AID317596, Type: Literature]Beta-1 adrenergic receptor [gi:48429211]
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5
[SID104234147]
EC50 8.4e-05Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzymeimmuno assay [AID344246, Type: Literature]Beta-1 adrenergic receptor [gi:48429211]
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6
[SID104234147]
IC50 0.0001Inhibition of spontaneous contractions in isolated rat uterus [AID41474, Type: Literature]Beta-2 adrenergic receptor [gi:114768]
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7
[SID104234147]
IC50 0.0001Agonistic activity towards beta-2 adrenoceptor. IC50, the mean concentration required to produce 50% inhibition of uterine contraction [AID220922, Type: Literature]
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8
[SID104234147]
EC50 0.00084Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay [AID349760, Type: Literature]Beta-1 adrenergic receptor [gi:48429211]
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9
[SID104234147]
EC50 0.00084Agonist activity at human recombinant adrenergic beta2 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay [AID429598, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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10
[SID104234147]
EC50 0.00097Agonist activity at human cloned adrenergic beta3 receptor expressed in CHO cells assessed as cAMP accumulation [AID387245, Type: Literature]Beta-3 adrenergic receptor [gi:461604]
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11
[SID104234147]
EC50 0.00097Agonist activity at human cloned beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation [AID366403, Type: Literature]Beta-3 adrenergic receptor [gi:461604]
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12
[SID104234147]
EC50 0.00097Agonist activity at human recombinant beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzymeimmuno assay [AID344247, Type: Literature]Beta-3 adrenergic receptor [gi:461604]
View
13
[SID104234147]
EC50 0.00097Agonist activity at human recombinant beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay [AID349762, Type: Literature]Beta-3 adrenergic receptor [gi:461604]
View
14
[SID104234147]
EC50 0.00097Agonist activity at human beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA [AID317595, Type: Literature]Beta-3 adrenergic receptor [gi:461604]
View
15
[SID104234147]
EC50 0.00097Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-3 adrenergic receptor [AID246462, Type: Literature]Beta-3 adrenergic receptor [gi:461604]
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16
[SID104234147]
EC50 0.0015In vitro beta-adrenergic activity against beta-1 adrenergic receptor by stimulation of rate of contraction of guinea pig atria [AID220909, Type: Literature]
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17
[SID104234147]
EC50 0.002Agonist activity at human recombinant adrenergic beta3 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay [AID429597, Type: Literature]Beta-3 adrenergic receptor [gi:461604]
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18
[SID104234147]
EC50 0.002Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-2 adrenergic receptor [AID246461, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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19
[SID104234147]
EC50 0.002Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay [AID349761, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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20
[SID104234147]
EC50 0.002Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzymeimmuno assay [AID344248, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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21
[SID104234147]
EC50 0.002Agonist activity at human beta2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation [AID366406, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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22
[SID104234147]
EC50 0.003Agonist activity at human beta2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation [AID350869, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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23
[SID104234147]
EC50 0.003Agonist activity at human cloned adrenergic beta2 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay [AID420991, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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24
[SID104234147]
EC50 0.003Agonist activity at human cloned adrenergic beta2 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay [AID426895, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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25
[SID104234147]
EC50 0.0032Effective concentration for increasing potency force in guinea pig isolated left atria [AID73725, Type: Literature]
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26
[SID104234147]
EC50 0.0039Agonist activity at human adrenergic beta3 receptor expressed in CHO cells assessed as [3H]cAMP levels by radiolabeled ligand based assay [AID326595, Type: Literature]Beta-3 adrenergic receptor [gi:461604]
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27
[SID104234147]
IC50 0.0053In vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscle [AID220911, Type: Literature]
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28
[SID104234147]
EC50 0.0058Agonist activity at human adrenergic beta-3 receptor expressed in CHO cells assessed as cAMP levels by DELFIA method [AID326592, Type: Literature]Beta-3 adrenergic receptor [gi:461604]
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29
[SID104234147]
EC50 0.006Agonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atria [AID42047, Type: Literature]
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30
[SID104234147]
EC50 0.0062Effective concentration for increasing potency rate in guinea pig isolated right atria [AID73727, Type: Literature]
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31
[SID104234147]
EC50 0.007Beta adrenergic receptor agonistic activity for the stimulation of accumulation of cyclic AMP in cultured C6 glioma cells [AID41601, Type: Literature]
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32
[SID104234147]
EC50 0.00794Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay [AID414891, Type: Literature]Beta-1 adrenergic receptor [gi:48429211]
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33
[SID104234147]
EC50 0.00794Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation [AID623254, Type: Literature]Beta-1 adrenergic receptor [gi:48429211]
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34
[SID104234147]
EC50 0.00794Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins [AID483559, Type: Literature]Beta-1 adrenergic receptor [gi:48429211]
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35
[SID104234147]
EC50 0.00794Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation [AID611237, Type: Literature]Beta-1 adrenergic receptor [gi:48429211]
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36
[SID104234147]
EC50 0.01In vitro concentration required to produce 50% relaxation of rat detrusor [AID169094, Type: Literature]
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37
[SID90340610]
Potency 0.0106qHTS Validation Assay for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID488953, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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38
[SID104234147]
EC50 0.012Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay [AID420992, Type: Literature]Beta-1 adrenergic receptor [gi:48429211]
View
39
[SID104234147]
EC50 0.012Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay [AID426897, Type: Literature]Beta-1 adrenergic receptor [gi:48429211]
View
40
[SID104234147]
EC50 0.012Agonist activity at human beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation [AID350871, Type: Literature]Beta-3 adrenergic receptor [gi:461604]
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41
[SID104234147]
EC50 0.013In vitro beta adrenergic receptor activity against beta-3 adrenergic receptor in rat epididymal fat pads by stimulation of glycerol release from adipocytes. [AID41939, Type: Literature]
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42
[SID104234147]
EC50 0.019Induction of lipolysis in mouse C3H10T1/2 assessed as glycerol concentration [AID580171, Type: Literature]
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43
[SID104234147]
EC50 0.03Evaluated for Beta adrenergic receptor agonistic property in isolated guinea pig atria [AID41160, Type: Literature]
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44
[SID104234147]
EC50 0.03162Agonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contraction [AID647421, Type: Literature]Beta-2 adrenergic receptor [gi:81914759]
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45
[SID104234147]
EC50 0.03981Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay [AID414892, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
View
46
[SID104234147]
EC50 0.03981Agonist activity at human beta3 receptor expressed in CHO cells assessed as cAMP accumulation [AID623255, Type: Literature]Beta-3 adrenergic receptor [gi:461604]
View
47
[SID104234147]
EC50 0.03981Agonist activity at human adrenergic beta3 receptor expressed in CHO cells assessed as cAMP accumulation [AID611236, Type: Literature]Beta-3 adrenergic receptor [gi:461604]
View
48
[SID104234147]
EC50 0.03981Agonist activity at human recombinant beta3 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins [AID483560, Type: Literature]Beta-3 adrenergic receptor [gi:461604]
View
49
[SID104234147]
EC50 0.03981Agonist activity at human cloned beta3 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay [AID414894, Type: Literature]Beta-3 adrenergic receptor [gi:461604]
View
50
[SID104234147]
EC50 0.03981Agonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulation [AID611239, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
View