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NSC658853 (CID 377410) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(29)
 
 
Inactive(54)
 
 
Unspecified(1)
 
 
Top Targets:
DUF3371(6)
 
 
BioAssay Types:
Confirmatory(81)
 
 
 
 
Literature(3)
 
 
BioActivity Types:
AC50(21)
 
 
IC50(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 84    Data Row: 84   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID134418987]
AbsAC40_uM 0.164qPCR Assay for TRPM1 Expression Measured in Cell-Based System Using RT-PCR - 2084-09_Inhibitor_Dose_DryPowder_Activity [AID651770, Type: confirmatory]microphthalmia-associated transcription factor [Homo sapiens] [gi:7684294]
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2
[SID134418987]
AbsAC40_uM 0.179qPCR Assay for MITF Expression Measured in Cell-Based System Using RT-PCR - 2084-05_Inhibitor_Dose_DryPowder_Activity [AID651773, Type: confirmatory]microphthalmia-associated transcription factor [Homo sapiens] [gi:7684294]
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3
[SID134418987]
AbsAC40_uM 0.203qPCR Assay for CDK2 Expression Measured in Cell-Based System Using RT-PCR - 2084-11_Inhibitor_Dose_DryPowder_Activity [AID651772, Type: confirmatory]microphthalmia-associated transcription factor [Homo sapiens] [gi:7684294]
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4
[SID134418987]
AbsAC40_uM 0.227qPCR Assay for MLANA Expression Measured in Cell-Based System Using RT-PCR - 2084-13_Inhibitor_Dose_DryPowder_Activity [AID651795, Type: confirmatory]microphthalmia-associated transcription factor [Homo sapiens] [gi:7684294]
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5
[SID134418987]
AbsAC40_uM 0.336qPCR Assay for DCT Expression Measured in Cell-Based System Using RT-PCR - 2084-12_Inhibitor_Dose_DryPowder_Activity [AID651771, Type: confirmatory]microphthalmia-associated transcription factor [Homo sapiens] [gi:7684294]
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6
[SID134418987]
AC50_uM 0.459MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_Dose_DryPowder_Activity_Set6 [AID624440, Type: confirmatory]
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7
[SID134418987]
AC50_uM 0.806MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_Dose_DryPowder_Activity_Set5 [AID624363, Type: confirmatory]
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8
[SID134418987]
AC50_uM 0.806MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_Dose_DryPowder_Activity_Set2 [AID624290, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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9
[SID134418987]
AC50_uM 0.854MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_Dose_DryPowder_Activity_Set4 [AID624316, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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10
[SID134418987]
AC50_uM 0.913MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_Dose_DryPowder_Activity_Set7 [AID624426, Type: confirmatory]
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11
[SID134418987]
AC50_uM 1.1MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_Dose_DryPowder_Activity_Set3 [AID624259, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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12
[SID103592919]
IC50 1.8Antiproliferative activity against ERalpha positive human MCF7 cells after 72 hrs by MTS/PMS assay [AID347503, Type: Literature]
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13
[SID134418987]
AC50_uM 1.95MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_Dose_DryPowder_Activity_Set9 [AID651588, Type: confirmatory]
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14
[SID103592919]
IC50 2.1Antiproliferative activity against ERalpha negative/Her2 over expressing human SKBR3 cells after 72 hrs by MTS/PMS assay [AID347638, Type: Literature]
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15
[SID134418987]
AC50_uM 3.94MITF Orthogonal Assay: SK-MEL-5 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-02_Inhibitor_Dose_DryPowder_Activity_Set8 [AID651586, Type: confirmatory]
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16
[SID134418987]
AC50_uM 4.73MITF Orthogonal Assay: SK-MEL-5 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-02_Inhibitor_Dose_DryPowder_Activity_Set2 [AID624289, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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17
[SID134418987]
AC50_uM 5.7MITF Orthogonal Assay: MALME3 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-04_Inhibitor_Dose_DryPowder_Activity_Set2 [AID624299, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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18
[SID134418987]
AC50_uM 7.33MITF Orthogonal Assay: MALME3 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-04_Inhibitor_Dose_DryPowder_Activity_Set5 [AID651584, Type: confirmatory]
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19
[SID134418987]
AC50_uM 7.33MITF Orthogonal Assay: MALME3 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-04_Inhibitor_Dose_DryPowder_Activity_Set6 [AID651585, Type: confirmatory]
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20
[SID134418987]
AC50_uM 9.1MITF Orthogonal Assay: SK-MEL-5 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-02_Inhibitor_Dose_DryPowder_Activity_Set3 [AID624315, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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21
[SID134418987]
AC50_uM 9.85MITF Orthogonal Assay: SK-MEL-5 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-02_Inhibitor_Dose_DryPowder_Activity_Set6 [AID624429, Type: confirmatory]
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22
[SID134418987]
AC50_uM 13.49MITF Orthogonal Assay: SK-MEL-5 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-02_Inhibitor_Dose_DryPowder_Activity_Set5 [AID624427, Type: confirmatory]
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23
[SID134418987]
AC50_uM 16.48MITF: Counter assay: A375 proliferation Measured in Cell-Based System Using Plate Reader - 2084-03_Inhibitor_Dose_DryPowder_Activity_Set6 [AID624488, Type: confirmatory]
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24
[SID134418987]
AC50_uM 22.84MITF: Counter assay: A375 proliferation Measured in Cell-Based System Using Plate Reader - 2084-03_Inhibitor_Dose_DryPowder_Activity_Set2 [AID624489, Type: confirmatory]
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25
[SID134418987]
AC50_uM 23.12MITF: Counter assay: A375 proliferation Measured in Cell-Based System Using Plate Reader - 2084-03_Inhibitor_Dose_DryPowder_Activity_Set7 [AID624490, Type: confirmatory]
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26
[SID134418987]
AC50_uM 28.73MITF: Counter assay: A375 proliferation Measured in Cell-Based System Using Plate Reader - 2084-03_Inhibitor_Dose_DryPowder_Activity_Set9 [AID651591, Type: confirmatory]
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27
[SID134418987]
AC50_uM 29.88MITF: Counter assay: A375 proliferation Measured in Cell-Based System Using Plate Reader - 2084-03_Inhibitor_Dose_DryPowder_Activity_Set3 [AID624324, Type: confirmatory]
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28
[SID103592919]
IC50 30.1Inhibition of Hsp90 in human SKBR3 cells assessed as down-regulation of Her2 protein by ELISA [AID347502, Type: Literature]
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29
[SID134418987]
AC50_uM 45.91MITF: Counter assay: A375 proliferation Measured in Cell-Based System Using Plate Reader - 2084-03_Inhibitor_Dose_DryPowder_Activity_Set4 [AID624364, Type: confirmatory]
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30
[SID508485]
NCI human tumor cell line growth inhibition assay. Data for the SK-OV-3 Ovarian cell line [AID103, Type: confirmatory]
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31
[SID508485]
NCI human tumor cell line growth inhibition assay. Data for the OVCAR-4 Ovarian cell line [AID105, Type: confirmatory]
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32
[SID508485]
NCI human tumor cell line growth inhibition assay. Data for the OVCAR-5 Ovarian cell line [AID107, Type: confirmatory]
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33
[SID508485]
NCI human tumor cell line growth inhibition assay. Data for the OVCAR-8 Ovarian cell line [AID109, Type: confirmatory]
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34
[SID508485]
NCI human tumor cell line growth inhibition assay. Data for the RPMI-8226 Leukemia cell line [AID113, Type: confirmatory]
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35
[SID508485]
NCI human tumor cell line growth inhibition assay. Data for the SR Leukemia cell line [AID115, Type: confirmatory]
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36
[SID508485]
NCI human tumor cell line growth inhibition assay. Data for the CCRF-CEM Leukemia cell line [AID119, Type: confirmatory]
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37
[SID508485]
NCI human tumor cell line growth inhibition assay. Data for the K-562 Leukemia cell line [AID121, Type: confirmatory]
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38
[SID508485]
NCI human tumor cell line growth inhibition assay. Data for the MOLT-4 Leukemia cell line [AID123, Type: confirmatory]
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39
[SID508485]
NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line [AID125, Type: confirmatory]
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40
[SID508485]
NCI human tumor cell line growth inhibition assay. Data for the RXF 393 Renal cell line [AID133, Type: confirmatory]
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41
[SID508485]
NCI human tumor cell line growth inhibition assay. Data for the 786-0 Renal cell line [AID137, Type: confirmatory]
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42
[SID508485]
NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line [AID139, Type: confirmatory]
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43
[SID508485]
NCI human tumor cell line growth inhibition assay. Data for the TK-10 Renal cell line [AID141, Type: confirmatory]
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44
[SID508485]
NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line [AID145, Type: confirmatory]
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45
[SID508485]
NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line [AID1, Type: confirmatory]
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46
[SID508485]
NCI human tumor cell line growth inhibition assay. Data for the NCI-H226 Non-Small Cell Lung cell line [AID3, Type: confirmatory]
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47
[SID508485]
NCI human tumor cell line growth inhibition assay. Data for the NCI-H322M Non-Small Cell Lung cell line [AID5, Type: confirmatory]
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48
[SID508485]
NCI human tumor cell line growth inhibition assay. Data for the NCI-H460 Non-Small Cell Lung cell line [AID7, Type: confirmatory]
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49
[SID508485]
NCI human tumor cell line growth inhibition assay. Data for the HOP-62 Non-Small Cell Lung cell line [AID9, Type: confirmatory]
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50
[SID508485]
NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line [AID13, Type: confirmatory]
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