4-piperidinecarboxylic acid (CID 3773) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(5)
 
 
Inactive(233)
 
 
Inconclusive(19)
 
 
Unspecified(28)
 
 
Top Targets:
Neur chan LBD(11)
 
 
p450(10)
 
 
 
Pyr redox dim(5)
 
 
PLN02808(5)
 
 
HELICc(4)
 
 
BioAssay Types:
Confirmatory(209)
 
 
 
 
Literature(36)
 
 
 
 
Screening(23)
 
 
Summary(1)
 
 
BioActivity Types:
Potency(182)
 
 
 
 
IC50(9)
 
 
 
 
EC50(8)
 
 
 
Ki(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 254    Data Row: 285   Total Pages: 6   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103179764]
IC50 0.33Inhibition of [3H]GABA binding to Gamma-aminobutyric acid receptor of rat brain synaptosomal membranes [AID71448, Type: Literature]
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2
[SID103179764]
IC50 15.8489Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
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3
[SID103179764]
IC50 15.8489Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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4
[SID103179764]
IC50 15.8489Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay [AID524795, Type: Literature]
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5
[SID103179764]
IC50 15.8489Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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6
[SID103179764]
IC50 94.1Inhibitory concentration required to inhibit [3H]strychnine binding to N-methyl-D-aspartate glutamate receptor 1 [AID143614, Type: Literature]
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7
[SID103179764]
EC50 160Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-6-beta-3-gamma-2 [AID73542, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-3 [gi:120773]
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8
[SID103179764]
IC50 300Inhibition of high affinity neuronal GABA uptake by synaptosomes of rat brain membrane [AID180670, Type: Literature]Sodium- and chloride-dependent GABA transporter 1 [gi:128609]
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9
[SID103179764]
EC50 300Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-4-beta-3-gamma-2 [AID73365, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-3 [gi:120773]
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10
[SID103179764]
EC50 370Effective dose for agonist activity on activity on human Gamma-aminobutyric acid A receptor alpha-3-beta-3-gamma-2 expressed in Xenopus oocytes [AID73238, Type: Literature]
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11
[SID103179764]
EC50 420Agonist activity on human Gamma-aminobutyric acid A receptor alpha-2-beta-3-gamma-2 expressed in Xenopus oocytes [AID73084, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-3 [gi:120773]
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12
[SID103179764]
EC50 620Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-1-beta-3-gamma-2 expressed in Xenopus oocytes [AID72923, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-3 [gi:120773]
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13
[SID103179764]
EC50 690Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-5-beta-3-gamma-2 expressed in Xenopus oocytes [AID73519, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-3 [gi:120773]
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14
[SID103179764]
Ki 2300Inhibition of human PAT1-mediated L-[3H]proline uptake in human Caco2 cells after 10 mins by liquid scintillation counting [AID630741, Type: Literature]
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15
[SID103179764]
 Maximal response relative to Gamma-aminobutyric acid A against human Gamma-aminobutyric-acid A receptor alpha-4-beta-3-gamma-2 expressed in Xenopus oocytes [AID73368, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-3 [gi:120773]
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16
[SID103179764]
 Maximal response relative to Gamma-aminobutyric acid A against human Gamma-aminobutyric-acid A receptor alpha-2-beta-3-gamma-2 expressed in Xenopus oocytes [AID73218, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-3 [gi:120773]
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17
[SID103179764]
 Maximal response relative to Gamma-aminobutyric acid A against human Gamma-aminobutyric-acid A receptor alpha-6-beta-3-gamma-2 expressed in Xenopus oocytes [AID71270, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-3 [gi:120773]
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18
[SID50105710]
Potency qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding [AID2675, Type: confirmatory]muscleblind-like protein 1 isoform a [Homo sapiens] [gi:41281591]
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19
[SID103179764]
 pKA value was determined; Experiment 1 [AID25081, Type: Literature]
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20
[SID103179764]
 pKA value was determined; Experiment 2 [AID25082, Type: Literature]
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21
[SID103179764]
 Agonist activity against Gamma-aminobutyric acid C (GABA-C) receptor derived from bovine retinal RNA expressed in Xenopus oocytes [AID71407, Type: Literature]
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22
[SID103179764]
 Change in input resistance of cultured spinal cord neurons produced at a dose 1 mM [AID223759, Type: Literature]
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23
[SID103179764]
 Change in input resistance of cultured spinal cord neurons produced at a dose 1 mM+100 uM bicuculline+3 uMtetrodotoxin [AID223762, Type: Literature]
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24
[SID103179764]
 Change in input resistance of cultured spinal cord neurons produced at a dose 100 uM [AID223764, Type: Literature]
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25
[SID103179764]
 Change in input resistance of cultured spinal cord neurons produced at a dose 100 uM+100 uM bicuculline+3 uM tetrodotoxin [AID223767, Type: Literature]
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26
[SID103179764]
 Effective dose required for anticonvulsive activity in bicuculline (BIC) test at >0.1 mmol/kg; Not effective [AID225509, Type: Literature]
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27
[SID103179764]
 Effective dose required for anticonvulsive activity in bicuculline (BIC) test; Not effective [AID225510, Type: Literature]
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28
[SID103179764]
 Effective dose required for anticonvulsive activity in maximal electroshock seizure (MES) test at >0.1 mmol/kg; Not effective [AID225512, Type: Literature]
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29
[SID103179764]
 Anticonvulsive activity in picrotoxin (PCR) induced seizure test at >0.1 mmol/kg (ineffective) [AID225519, Type: Literature]
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30
[SID11111343]
 Cytochrome panel assay with activity outcomes [AID1851, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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31
[SID11111343]
 Cytochrome panel assay with activity outcomes [AID1851, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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32
[SID103179764]
 Maximal response relative to Gamma-aminobutyric acid A against human Gamma-aminobutyric-acid A receptor alpha-5-beta-3-gamma-2 expressed in Xenopus oocytes [AID73533, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-3 [gi:120773]
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33
[SID103179764]
 Maximal response relative to Gamma-aminobutyric acid A against human Gamma-aminobutyric-acid A receptor alpha-1-beta-3-gamma-2 expressed in Xenopus oocytes [AID73068, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-3 [gi:120773]
View
34
[SID103179764]
 Maximal response relative to Gamma-aminobutyric acid A against human Gamma-aminobutyric-acid A receptor alpha-3-beta-3-gamma-2 expressed in Xenopus oocytes [AID73362, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-3 [gi:120773]
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35
[SID85231096]
Potency 0.5973qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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36
[SID85231096]
Potency 0.5973qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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37
[SID50105710]
Potency 10qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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38
[SID50105710]
Potency 44.6684qHTS Validation Assay for Identification of Novel General Anesthetics [AID2323, Type: confirmatory]Chain A, Horse Spleen Apoferritin [gi:254220970]
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39
[SID90341183]
Potency qHTS validation assay of beta-arrestin-biased ligands of beta2-adrenergic receptor [AID485366, Type: confirmatory]ADRB2 gene product [Homo sapiens] [gi:4501969]
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40
[SID90341183]
Potency qHTS validation assay of beta-arrestin-biased ligands of beta2-adrenergic receptor [AID485366, Type: confirmatory]ADRB2 gene product [Homo sapiens] [gi:4501969]
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41
[SID90341183]
Potency qHTS validation assay of beta-arrestin-biased ligands of beta2-adrenergic receptor [AID485366, Type: confirmatory]ADRB2 gene product [Homo sapiens] [gi:4501969]
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42
[SID90341183]
Potency qHTS validation assay of beta-arrestin-biased ligands of beta2-adrenergic receptor [AID485366, Type: confirmatory]ADRB2 gene product [Homo sapiens] [gi:4501969]
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43
[SID50105710]
Potency qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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44
[SID50105710]
Potency qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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45
[SID8139887]
Potency qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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46
[SID8139887]
Potency qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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47
[SID8139887]
Potency qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase) [AID1452, Type: confirmatory]arachidonate 12-lipoxygenase, 12S-type [Homo sapiens] [gi:154426292]
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48
[SID8139887]
Potency qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase) [AID1452, Type: confirmatory]arachidonate 12-lipoxygenase, 12S-type [Homo sapiens] [gi:154426292]
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49
[SID11111343]
Potency qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase) [AID1452, Type: confirmatory]arachidonate 12-lipoxygenase, 12S-type [Homo sapiens] [gi:154426292]
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50
[SID11111343]
Potency qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase) [AID1452, Type: confirmatory]arachidonate 12-lipoxygenase, 12S-type [Homo sapiens] [gi:154426292]
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