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4-piperidinecarboxylic acid (CID 3773) - Compound BioActivity Data
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BioActivity Outcomes:
Active(5)
 
 
Inactive(258)
 
 
Inconclusive(20)
 
 
Unspecified(53)
 
 
Top Targets:
Neur chan LBD(22)
 
 
Neur chan mem..(11)
 
 
p450(9)
 
 
HSD10-like SD..(8)
 
 
7TM GPCR Srx(7)
 
 
 
BioAssay Types:
Confirmatory(232)
 
 
 
 
Literature(63)
 
 
 
 
Screening(24)
 
 
Summary(1)
 
 
BioActivity Types:
Potency(202)
 
 
 
 
EC50(18)
 
 
 
IC50(13)
 
 
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 263    Data Row: 336   Total Pages: 7   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103179764]
IC50 0.33Inhibition of [3H]GABA binding to Gamma-aminobutyric acid receptor of rat brain synaptosomal membranes [AID71448, Type: Literature]
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2
[SID103179764]
IC50 15.8489Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
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3
[SID103179764]
IC50 15.8489Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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4
[SID103179764]
IC50 15.8489Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay [AID524795, Type: Literature]
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5
[SID103179764]
IC50 15.8489Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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6
[SID103179764]
IC50 94.1Inhibitory concentration required to inhibit [3H]strychnine binding to N-methyl-D-aspartate glutamate receptor 1 [AID143614, Type: Literature]
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7
[SID103179764]
EC50 160Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-6-beta-3-gamma-2 [AID73542, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-3 [gi:120773]
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8
[SID103179764]
EC50 160Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-6-beta-3-gamma-2 [AID73542, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:116242488]
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9
[SID103179764]
EC50 160Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-6-beta-3-gamma-2 [AID73542, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-6 [gi:126302548]
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10
[SID103179764]
EC50 300Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-4-beta-3-gamma-2 [AID73365, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:116242488]
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11
[SID103179764]
EC50 300Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-4-beta-3-gamma-2 [AID73365, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-3 [gi:120773]
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12
[SID103179764]
IC50 300Inhibition of high affinity neuronal GABA uptake by synaptosomes of rat brain membrane [AID180670, Type: Literature]Sodium- and chloride-dependent GABA transporter 1 [gi:128609]
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13
[SID103179764]
IC50 300Inhibition of high affinity neuronal GABA uptake by synaptosomes of rat brain membrane [AID180670, Type: Literature]Sodium- and chloride-dependent GABA transporter 2 [gi:400624]
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14
[SID103179764]
IC50 300Inhibition of high affinity neuronal GABA uptake by synaptosomes of rat brain membrane [AID180670, Type: Literature]Sodium- and chloride-dependent GABA transporter 3 [gi:400626]
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15
[SID103179764]
IC50 300Inhibition of high affinity neuronal GABA uptake by synaptosomes of rat brain membrane [AID180670, Type: Literature]Sodium- and chloride-dependent betaine transporter [gi:1352527]
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16
[SID103179764]
EC50 300Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-4-beta-3-gamma-2 [AID73365, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-4 [gi:206729865]
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17
[SID103179764]
EC50 370Effective dose for agonist activity on activity on human Gamma-aminobutyric acid A receptor alpha-3-beta-3-gamma-2 expressed in Xenopus oocytes [AID73238, Type: Literature]
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18
[SID103179764]
EC50 420Agonist activity on human Gamma-aminobutyric acid A receptor alpha-2-beta-3-gamma-2 expressed in Xenopus oocytes [AID73084, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-3 [gi:120773]
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19
[SID103179764]
EC50 420Agonist activity on human Gamma-aminobutyric acid A receptor alpha-2-beta-3-gamma-2 expressed in Xenopus oocytes [AID73084, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-2 [gi:126302547]
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20
[SID103179764]
EC50 420Agonist activity on human Gamma-aminobutyric acid A receptor alpha-2-beta-3-gamma-2 expressed in Xenopus oocytes [AID73084, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:116242488]
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21
[SID103179764]
EC50 620Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-1-beta-3-gamma-2 expressed in Xenopus oocytes [AID72923, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:116242488]
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22
[SID103179764]
EC50 620Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-1-beta-3-gamma-2 expressed in Xenopus oocytes [AID72923, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-1 [gi:27808653]
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23
[SID103179764]
EC50 620Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-1-beta-3-gamma-2 expressed in Xenopus oocytes [AID72923, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-3 [gi:120773]
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24
[SID103179764]
EC50 690Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-5-beta-3-gamma-2 expressed in Xenopus oocytes [AID73519, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-5 [gi:399519]
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25
[SID103179764]
EC50 690Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-5-beta-3-gamma-2 expressed in Xenopus oocytes [AID73519, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-3 [gi:120773]
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26
[SID103179764]
EC50 690Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-5-beta-3-gamma-2 expressed in Xenopus oocytes [AID73519, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:116242488]
View
27
[SID103179764]
Ki 2300Inhibition of human PAT1-mediated L-[3H]proline uptake in human Caco2 cells after 10 mins by liquid scintillation counting [AID630741, Type: Literature]Proton-coupled amino acid transporter 1 [gi:51316800]
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28
[SID50105710]
Potency qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding [AID2675, Type: confirmatory]muscleblind-like protein 1 isoform a [Homo sapiens] [gi:41281591]
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29
[SID103179764]
Maximal response relative to Gamma-aminobutyric acid A against human Gamma-aminobutyric-acid A receptor alpha-4-beta-3-gamma-2 expressed in Xenopus oocytes [AID73368, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:116242488]
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30
[SID103179764]
Maximal response relative to Gamma-aminobutyric acid A against human Gamma-aminobutyric-acid A receptor alpha-5-beta-3-gamma-2 expressed in Xenopus oocytes [AID73533, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:116242488]
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31
[SID103179764]
Maximal response relative to Gamma-aminobutyric acid A against human Gamma-aminobutyric-acid A receptor alpha-1-beta-3-gamma-2 expressed in Xenopus oocytes [AID73068, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-1 [gi:27808653]
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32
[SID103179764]
Maximal response relative to Gamma-aminobutyric acid A against human Gamma-aminobutyric-acid A receptor alpha-2-beta-3-gamma-2 expressed in Xenopus oocytes [AID73218, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:116242488]
View
33
[SID103179764]
Maximal response relative to Gamma-aminobutyric acid A against human Gamma-aminobutyric-acid A receptor alpha-6-beta-3-gamma-2 expressed in Xenopus oocytes [AID71270, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:116242488]
View
34
[SID103179764]
Maximal response relative to Gamma-aminobutyric acid A against human Gamma-aminobutyric-acid A receptor alpha-1-beta-3-gamma-2 expressed in Xenopus oocytes [AID73068, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:116242488]
View
35
[SID103179764]
Maximal response relative to Gamma-aminobutyric acid A against human Gamma-aminobutyric-acid A receptor alpha-6-beta-3-gamma-2 expressed in Xenopus oocytes [AID71270, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-6 [gi:126302548]
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36
[SID103179764]
Maximal response relative to Gamma-aminobutyric acid A against human Gamma-aminobutyric-acid A receptor alpha-3-beta-3-gamma-2 expressed in Xenopus oocytes [AID73362, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:116242488]
View
37
[SID103179764]
Maximal response relative to Gamma-aminobutyric acid A against human Gamma-aminobutyric-acid A receptor alpha-5-beta-3-gamma-2 expressed in Xenopus oocytes [AID73533, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-3 [gi:120773]
View
38
[SID103179764]
Maximal response relative to Gamma-aminobutyric acid A against human Gamma-aminobutyric-acid A receptor alpha-5-beta-3-gamma-2 expressed in Xenopus oocytes [AID73533, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-5 [gi:399519]
View
39
[SID103179764]
Maximal response relative to Gamma-aminobutyric acid A against human Gamma-aminobutyric-acid A receptor alpha-1-beta-3-gamma-2 expressed in Xenopus oocytes [AID73068, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-3 [gi:120773]
View
40
[SID103179764]
Maximal response relative to Gamma-aminobutyric acid A against human Gamma-aminobutyric-acid A receptor alpha-6-beta-3-gamma-2 expressed in Xenopus oocytes [AID71270, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-3 [gi:120773]
View
41
[SID103179764]
Maximal response relative to Gamma-aminobutyric acid A against human Gamma-aminobutyric-acid A receptor alpha-3-beta-3-gamma-2 expressed in Xenopus oocytes [AID73362, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-3 [gi:120773]
View
42
[SID103179764]
Maximal response relative to Gamma-aminobutyric acid A against human Gamma-aminobutyric-acid A receptor alpha-4-beta-3-gamma-2 expressed in Xenopus oocytes [AID73368, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-3 [gi:120773]
View
43
[SID103179764]
Maximal response relative to Gamma-aminobutyric acid A against human Gamma-aminobutyric-acid A receptor alpha-3-beta-3-gamma-2 expressed in Xenopus oocytes [AID73362, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-3 [gi:462149]
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44
[SID103179764]
Change in input resistance of cultured spinal cord neurons produced at a dose 1 mM [AID223759, Type: Literature]
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45
[SID103179764]
Change in input resistance of cultured spinal cord neurons produced at a dose 1 mM+100 uM bicuculline+3 uMtetrodotoxin [AID223762, Type: Literature]
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46
[SID103179764]
Change in input resistance of cultured spinal cord neurons produced at a dose 100 uM [AID223764, Type: Literature]
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47
[SID103179764]
Change in input resistance of cultured spinal cord neurons produced at a dose 100 uM+100 uM bicuculline+3 uM tetrodotoxin [AID223767, Type: Literature]
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48
[SID103179764]
Effective dose required for anticonvulsive activity in bicuculline (BIC) test at >0.1 mmol/kg; Not effective [AID225509, Type: Literature]
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49
[SID103179764]
Effective dose required for anticonvulsive activity in bicuculline (BIC) test; Not effective [AID225510, Type: Literature]
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50
[SID103179764]
Effective dose required for anticonvulsive activity in maximal electroshock seizure (MES) test at >0.1 mmol/kg; Not effective [AID225512, Type: Literature]
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