Ribavirin (CID 37542) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(236)
 
 
Inactive(951)
 
 
Inconclusive(98)
 
 
Unspecified(1392)
 
 
Top Targets:
7TM GPCR Srx(36)
 
 
 
7TM GPCR Srsx(20)
 
 
 
NR LBD PPAR(11)
 
 
 
Pyr redox dim(10)
 
 
p450(10)
 
 
 
 
BioAssay Types:
Literature(1498)
 
 
 
 
 
Confirmatory(467)
 
 
 
 
 
Screening(454)
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(374)
 
 
 
 
 
EC50(254)
 
 
 
 
 
IC50(218)
 
 
 
 
 
AC50(4)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2572    Data Row: 2677   Total Pages: 54   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103619997]
EC50 0.005Effective concentration required to inhibit Herpes simplex virus-1(HSV-1) / thymine kinase deficient (TK-)B2006 / VMW1837 induced cytopathicity by 50% in E6SM cell lines [AID63915, Type: Literature]
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2
[SID103619997]
IC50 1Inhibition of IMPDH in mouse L1210 cells assessed as formation of [2,8-3H]hypoxanthine from [2,8-3H]IMP after 20 to 60 mins [AID665016, Type: Literature]
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3
[SID103619997]
IC50 1Inhibition of IMPDH in human CEM cells assessed as formation of [2,8-3H]hypoxanthine from [2,8-3H]IMP after 20 to 60 mins [AID665017, Type: Literature]
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4
[SID8139972]
Potency 1.0323qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID8139972]
Potency 1.0323qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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6
[SID8139972]
Potency 1.0323qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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7
[SID103619997]
EC50 1.1Inhibition of West Nile virus VLP replicon in BHK21 cell line [AID261589, Type: Literature]
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8
[SID144203810]
Potency 1.1582qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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9
[SID144203810]
Potency 1.1582qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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10
[SID144203810]
Potency 1.1582qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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11
[SID144203810]
Potency 1.1582qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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12
[SID144203810]
Potency 1.1582qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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13
[SID144203810]
Potency 1.1582qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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14
[SID8139972]
Potency 1.4581qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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15
[SID8139972]
Potency 1.4581qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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16
[SID8139972]
Potency 1.4581qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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17
[SID103619997]
EC50 1.5Anti BVDV activity in MDBK (Madin-darby bovine kidney) cells [AID246174, Type: Literature]
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18
[SID103619997]
EC50 1.5Effective concentration required to inhibit respiratory synaptial(RSV) virus-induced cytopathicity by 50% in HeLa cell lines [AID86683, Type: Literature]
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19
[SID103619997]
IC50 1.9Antiinfluenza activity against influenza A virus H1N1 infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect after 36 hrs [AID648646, Type: Literature]
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20
[SID103619997]
EC50 2.3Antiviral activity against influenza A virus H1N1 infected in MDCK cells assessed as inhibition of virus-induced cytopathogenicity [AID659286, Type: Literature]
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21
[SID103619997]
EC50 3Antiviral activity against RSV infected in HeLa cells assessed as protection against virus-induced cytopathicity [AID611758, Type: Literature]
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22
[SID103619997]
EC50 3.6Antiviral activity against Influenza B virus (B/Hong Kong/5/72) assessed as cell viability by cell-based MTS assay [AID443832, Type: Literature]
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23
[SID103619997]
EC50 3.7Antiviral activity against influenza A H2N2(A2 japan/305/57) in MDCK cells [AID105946, Type: Literature]
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24
[SID103619997]
IC50 3.9Antiinfluenza activity against influenza A virus H3N2 infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect after 36 hrs [AID648645, Type: Literature]
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25
[SID103619997]
EC50 4Antiviral activity against influenza B virus assessed as inhibition of viral induced cytopathic effect [AID478324, Type: Literature]
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26
[SID103619997]
EC50 4Antiviral activity against influenza B virus in MDCK cells assessed as reduction of virus-induced cytopathicity by visual cytopathic effect scoring method [AID416784, Type: Literature]
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27
[SID103619997]
EC50 4.3Antiviral activity against Influenza A virus Hong Kong/213/2003/H5N1 infected MDCK cells assessed as inhibition of virus-induced cytopathic effect after 3 days [AID474331, Type: Literature]
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28
[SID103619997]
EC50 4.5Antiviral activity against influenza B virus infected in MDCK cells assessed as inhibition of virus-induced cytopathogenicity [AID659287, Type: Literature]
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29
[SID103619997]
EC50 4.62Antiviral activity against bovine viral diarrhoea virus type-1 NADL in MDBK cells assessed as inhibition of virus-induced cytopathic effect [AID371498, Type: Literature]
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30
[SID103619997]
EC50 4.7Antiviral activity against influenza B virus assessed as cell viability by cell based MTS assay [AID478325, Type: Literature]
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31
[SID103619997]
EC50 4.8Antiviral activity against Influenza B virus infected in MDCK cells assessed as inhibition of virus-induced cytopathogenicity after 4 days by colorimetric formazan-based MTS assay [AID658751, Type: Literature]
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32
[SID103619997]
EC50 4.8Antiviral activity against influenza B virus in MDCK cells assessed as reduction of virus-induced cytopathicity by MTS method [AID416785, Type: Literature]
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33
[SID103619997]
IC50 4.9Inhibitory concentration against influenza virus A in MDCK cells [AID105769, Type: Literature]
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34
[SID103619997]
EC50 4.92Antiviral activity against adamantane-, oseltamivir-, zanamivir-susceptible Influenza A virus (A/Georgia/17/2006(H1N1)) infected in MDCK cells assessed as inhibition of viral replication after 3 days by microscopic analysis using crystal violet stain [AID575124, Type: Literature]
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35
[SID103619997]
IC50 5.04Antiviral activity against influenza A/Jifang/15/90 (H3N2) virus in MDCK cells by CPE assay [AID300559, Type: Literature]
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36
[SID103619997]
EC50 5.1Antiviral activity against Influenza A virus H3N2 infected in MDCK cells assessed as inhibition of virus-induced cytopathogenicity [AID659285, Type: Literature]
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37
[SID103619997]
EC50 5.6Antiviral activity against Influenza A virus H3N2 infected in MDCK cells assessed as inhibition of virus-induced cytopathogenicity after 4 days by colorimetric formazan-based MTS assay [AID658750, Type: Literature]
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38
[SID103619997]
IC50 5.7Compound was tested for its effect on the proliferation of MOLT-4 human lymphoblastic T-leukemia cell line. [AID105300, Type: other]
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39
[SID103619997]
IC50 5.85Antiviral activity against influenza A/Yuefang/243/72 (H3N2) virus in MDCK cells by CPE assay [AID300558, Type: Literature]
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40
[SID103619997]
EC50 6Antiviral activity against Influenza A virus (A/Hong Kong/7/87(H3N2)) assessed as cell viability by cell-based MTS assay [AID443830, Type: Literature]
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41
[SID103619997]
EC50 6.6Antiviral activity against RSV infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS assay [AID489677, Type: Literature]
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42
[SID103619997]
EC50 6.7Antiviral activity against Influenza A virus H1N1 infected in MDCK cells assessed as inhibition of virus-induced cytopathogenicity after 4 days by colorimetric formazan-based MTS assay [AID658749, Type: Literature]
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43
[SID103619997]
EC50 7Antiviral activity against Influenza A virus H1N1 infected in MDCK cells assessed as reduction visual scoring of virus-induced cytopathogenicity after 4 days [AID658746, Type: Literature]
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44
[SID103619997]
EC50 7Antiviral activity against Influenza A virus H3N2 infected in MDCK cells assessed as reduction visual scoring of virus-induced cytopathogenicity after 4 days [AID658747, Type: Literature]
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45
[SID103619997]
EC50 7Antiviral activity against Influenza B virus infected in MDCK cells assessed as reduction visual scoring of virus-induced cytopathogenicity after 4 days [AID658748, Type: Literature]
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46
[SID103619997]
EC50 7Antiviral activity against Influenza A virus H1N1 infected in MDCK cells assessed as protection from virus-induced cytopathogenicity after 6 to 7 days by MTT assay [AID464000, Type: Literature]
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47
[SID103619997]
EC50 7Antiviral activity against Bovine viral diarrhea virus NADL infected in MDBK cells assessed as protection from virus-induced cytopathogenicity after 3 to 4 days by MTT method [AID472789, Type: Literature]
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48
[SID103619997]
EC50 7Antiviral activity against RSV A2 infected in african green monkey Vero cells after 5 days by plaque reduction assay [AID472794, Type: Literature]
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49
[SID103619997]
EC50 7Antiviral activity against Respiratory syncytial virus A2 infected in Vero-76 cells after 5 days by plaque reduction assay [AID436483, Type: Literature]
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50
[SID103619997]
EC50 7Antiviral activity against Bovine viral diarrhea virus infected in MDBK cells assessed as inhibition of virus-induced cytopathicity after 3 to 4 days by MTT assay [AID436478, Type: Literature]
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