2-phenyl-7-(propan-2-yloxy)-4h-chromen-4-one (CID 3745) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(3)
 
 
Inactive(135)
 
 
Inconclusive(38)
 
 
Unspecified(12)
 
 
Top Targets:
P53(3)
 
 
 
HELICc(2)
 
 
Peptidase C1A(2)
 
 
Menin(2)
 
 
 
PMP22 Claudin(2)
 
 
BioAssay Types:
Confirmatory(73)
 
 
 
 
Literature(62)
 
 
 
 
 
Screening(17)
 
 
BioActivity Types:
Potency(71)
 
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 127    Data Row: 188   Total Pages: 4   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26749889]
Potency 0.8087Biochemical firefly luciferase enzyme assay for NPC [AID624030, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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2
[SID26749889]
Potency 6.3096qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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3
[SID26749889]
Potency 6.3096qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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4
[SID26749889]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_3, Type: Literature]
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5
[SID8149182]
 Assay to identify inhibitors of polyglutamine-induced caspase-3 activation (CASP3) [AID1583, Type: other]
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6
[SID8149182]
 Yeast cell-based screen for compounds that suppress polyglutamine aggregation in vivo (75Q-TubU) [AID1593, Type: other]
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7
[SID8149182]
 Screen for compounds that correct neuronal dysfunction without cell death as induced by the expression of polyglutamine-expanded, N-terminal huntingtin in C. elegans mechanosensory neurons (HDELENEU) [AID1599, Type: other]
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8
[SID8149182]
 Screen for compounds that selectively inhibit cytochrome c release from purified mitochondria (CytoCRel) [AID1603, Type: other]
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9
[SID8149182]
 Screen for compounds that inhibit polyglutamine induced protein aggregation (AGREG) [AID1604, Type: other]
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10
[SID8149182]
 Screening of compounds showing protective effect against cell death induced by familial amyotrophic lateral sclerosis (FALS)-linked mutantsuperoxide dismutase 1 (SOD1) (ALSOD1) [AID1605, Type: other]
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11
[SID8149182]
 Screen for compounds that induce the human heat shock transcriptional response (HSEluc) [AID1611, Type: other]
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12
[SID8149182]
 Screen for compounds that increase glutamate transport activity in MN-1 cell line (GluUPTAKE) [AID1612, Type: other]
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13
[SID8149182]
 Screen for compounds that inhibit protein aggregation formed by mutant SOD1 (GFPSOD1) [AID1613, Type: other]
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14
[SID8149182]
 Screen for compounds that reduce polyglutamine (polyQ) inclusions in nerve growth factor (NGF)-treated PC12 cells (GFPQ80) [AID1614, Type: other]
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15
[SID8149182]
 Yeast cell-based screen for compounds that suppress polyglutamine aggregation in vivo (75Q-TubH) [AID1616, Type: other]
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16
[SID26749889]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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17
[SID26749889]
Potency 0.2557S16 Schwann cell PMP22 intronic element firefly luciferase assay [AID624032, Type: confirmatory]Pmp22 gene product [Rattus norvegicus] [gi:8393992]
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18
[SID26749889]
Potency 0.3793Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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19
[SID26749889]
Potency 0.4775Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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20
[SID26749889]
Potency 3.9811qHTS Assay for Compounds that Induce Erasure of Genomic Imprints [AID1948, Type: confirmatory]
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21
[SID26749889]
Potency 12.5893qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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22
[SID26749889]
Potency 12.5893qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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23
[SID26749889]
Potency 12.5893qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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24
[SID26749889]
Potency qHTS Assay for Lipid Storage Modulators [AID1519, Type: confirmatory]
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25
[SID26749889]
Potency Quantitative High-Throughput Screen for Regulators of Epigenetic Control [AID1865, Type: confirmatory]
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26
[SID85787411]
 Luminescence Cell-Based Primary HTS to Measure Viability of BJeLR cells [AID2275, Type: screening]
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27
[SID85787411]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of the Sonic Hedgehog Signaling Pathway [AID2313, Type: screening]
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28
[SID85787411]
 Luminescence Homogenous Primary HTS to Identify Inhibitors of STK33 Activity [AID2322, Type: screening]
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29
[SID85787411]
 Fluorescence Cell-Based Primary HTS to Measure Inhibition of Y box Binding Protein 1 Expression [AID434959, Type: screening]
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30
[SID26749889]
Potency S16 Schwann cell viability assay (CellTiter-Glo assay) [AID624031, Type: confirmatory]
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31
[SID85787411]
 Luminescence Cell-Based Primary HTS to Identify Re-Activators of the P53 Mutant Pathway Measured in Cell-Based System Using Plate Reader - 2071-01_Activator_SinglePoint_HTS_Activity [AID624151, Type: screening]
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32
[SID85787411]
 Fluorescence Cell-Based Primary HTS to Identify Reactive Oxygen Species Inducers in Cancer Cells Measured in Cell-Based System Using Plate Reader and Imaging Combination - 2044-01_Activator_SinglePoint_HTS_Activity [AID624156, Type: screening]
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33
[SID85787411]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of MITF [AID2240, Type: screening]microphthalmia-associated transcription factor isoform 1 [Homo sapiens] [gi:38156699]
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34
[SID85787411]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of MITF [AID2240, Type: screening]microphthalmia-associated transcription factor isoform 1 [Homo sapiens] [gi:38156699]
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35
[SID26749889]
Potency qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction [AID2662, Type: confirmatory]MLL gene product [Homo sapiens] [gi:56550039]
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36
[SID85787411]
 SMM c-myc Measured in Biochemical System Using Small Molecule MicroArray - 2081-01_Other_SinglePoint_HTS_Activity [AID624141, Type: screening]MYC gene product [Homo sapiens] [gi:71774083]
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37
[SID85787411]
 NF-KappaB Measured in Biochemical System Using Small Molecule MicroArray - 2080-01_Other_SinglePoint_HTS_Activity [AID624139, Type: screening]NFKB1 gene product [Homo sapiens] [gi:34577122]
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38
[SID85787411]
 NF-KappaB Measured in Biochemical System Using Small Molecule MicroArray - 2080-01_Other_SinglePoint_HTS_Activity [AID624139, Type: screening]NFKB1 gene product [Homo sapiens] [gi:34577122]
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39
[SID85787411]
 NF-KappaB Measured in Biochemical System Using Small Molecule MicroArray - 2080-01_Other_SinglePoint_HTS_Activity [AID624139, Type: screening]NFKB1 gene product [Homo sapiens] [gi:34577122]
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40
[SID85787411]
 NF-KappaB Measured in Biochemical System Using Small Molecule MicroArray - 2080-01_Other_SinglePoint_HTS_Activity [AID624139, Type: screening]NFKB1 gene product [Homo sapiens] [gi:34577122]
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41
[SID26749889]
Potency A Quantitative High throughput Screen to Identify Chemical Modulators of PINK1 Expression [AID624263, Type: confirmatory]Parkin [Homo sapiens] [gi:3063388]
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42
[SID26749889]
Potency qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF [AID1454, Type: confirmatory]mitogen-activated protein kinase 1 [Homo sapiens] [gi:66932916]
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43
[SID26749889]
Potency qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF [AID1454, Type: confirmatory]mitogen-activated protein kinase 1 [Homo sapiens] [gi:66932916]
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44
[SID26749889]
Potency qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF [AID1454, Type: confirmatory]mitogen-activated protein kinase 1 [Homo sapiens] [gi:66932916]
View
45
[SID26749889]
Potency qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay [AID995, Type: confirmatory]mitogen-activated protein kinase 1 [Homo sapiens] [gi:66932916]
View
46
[SID26749889]
Potency qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay [AID995, Type: confirmatory]mitogen-activated protein kinase 1 [Homo sapiens] [gi:66932916]
View
47
[SID26749889]
Potency qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay [AID995, Type: confirmatory]mitogen-activated protein kinase 1 [Homo sapiens] [gi:66932916]
View
48
[SID26611575]
 Modulators of the EP2 prostaglandin E2 receptor - Primary Screening [AID940, Type: screening]prostaglandin E receptor 2 (subtype EP2), 53kDa [Homo sapiens] [gi:31881630]
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49
[SID26611575]
 Modulators of the EP2 prostaglandin E2 receptor - Primary Screening [AID940, Type: screening]prostaglandin E receptor 2 (subtype EP2), 53kDa [Homo sapiens] [gi:31881630]
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50
[SID26611575]
 Inhibitors of the EP2 Prostaglandin E2 Receptor - Primary Screen [AID1422, Type: screening]prostaglandin E receptor 2 (subtype EP2), 53kDa [Homo sapiens] [gi:31881630]
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