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MLS002702927 (CID 373978) - Compound BioActivity Data
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BioActivity Outcomes:
Active(106)
 
 
Inactive(270)
 
 
Inconclusive(15)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(12)
 
 
7TM GPCR Srsx(11)
 
 
Alpha TIF(6)
 
 
Troponin(4)
 
 
PAX(4)
 
 
 
BioAssay Types:
Screening(227)
 
 
 
Confirmatory(153)
 
 
 
 
 
Literature(3)
 
 
BioActivity Types:
Potency(77)
 
 
 
 
 
AC50(10)
 
 
 
IC50(5)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 361    Data Row: 392   Total Pages: 8   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID92763369]
Potency 0.0116qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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2
[SID92763369]
Potency 0.0164qHTS for Inhibitors of TGF-b: Confirmation of Cherry Picks [AID720534, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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3
[SID92763369]
Potency 0.0164qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID92763369]
Potency 0.0366qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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5
[SID92763369]
Potency 0.0731qHTS for Inhibitors of TGF-b: Cytotox Counterscreen for Cherry Picks [AID720535, Type: confirmatory]
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6
[SID92763369]
Potency 0.2593qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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7
[SID92763369]
AC50_uM 0.26CEM21 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7013-03_Inhibitor_Dose_CherryPick_Activity [AID652042, Type: confirmatory]
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8
[SID92763369]
AC50_uM 0.26HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity [AID687027, Type: confirmatory]PAX8 [Homo sapiens] [gi:998701]
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9
[SID92763369]
AC50_uM 0.322HIV entry: Env-mediated Cell Fusion Measured in Cell-Based System Using Plate Reader - 7013-01_Inhibitor_Dose_CherryPick_Activity [AID652057, Type: confirmatory]
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10
[SID92763369]
Potency 0.3548qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS [AID720580, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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11
[SID92763369]
Potency 0.92qHTS for Inhibitors of TGF-b: CCL64 Cells Orthogonal Assay for Cherry Picks [AID720536, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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12
[SID92763369]
AC50_uM 2.04Cell fusion assay for clade C HIV-1ZM109 Env Measured in Cell-Based System Using Plate Reader - 7013-05_Inhibitor_Dose_CherryPick_Activity [AID652058, Type: confirmatory]
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13
[SID92763369]
AC50_uM 3.45HIV-1 Cell Fusion assay for clade B Env AD8 Measured in Cell-Based System Using Plate Reader - 7013-04_Inhibitor_Dose_CherryPick_Activity [AID652062, Type: confirmatory]
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14
[SID92763369]
AC50_uM 3.78Control Cell Fusion Counterscreen Assay Measured in Cell-Based System Using Plate Reader - 7013-02_Inhibitor_Dose_CherryPick_Activity [AID652040, Type: confirmatory]
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15
[SID92763369]
Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID588674, Type: screening]
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16
[SID92763369]
7011-01_Antagonist_SinglePoint_HTS_Activity [AID720647, Type: screening]
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17
[SID92763369]
HIV entry: Env-mediated Cell Fusion Measured in Cell-Based System Using Plate Reader - 7013-01_Inhibitor_SinglePoint_HTS_Activity [AID651610, Type: screening]
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18
[SID92763369]
Counterscreen for inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2): Luminescence-based cell-based high throughput assay to identify nonselective inhibitors of the Steroidogenic acute regulatory protein (StAR) promoter or luminescence assay artifacts [AID651611, Type: screening]
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19
[SID505150]
NCI human tumor cell line growth inhibition assay. Data for the DMS 273 Small Cell Lung cell line [AID61, Type: confirmatory]
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20
[SID505150]
NCI human tumor cell line growth inhibition assay. Data for the DMS 114 Small Cell Lung cell line [AID63, Type: confirmatory]
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21
[SID505150]
NCI human tumor cell line growth inhibition assay. Data for the HT29 Colon cell line [AID65, Type: confirmatory]
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22
[SID505150]
NCI human tumor cell line growth inhibition assay. Data for the COLO 205 Colon cell line [AID67, Type: confirmatory]
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23
[SID505150]
NCI human tumor cell line growth inhibition assay. Data for the DLD-1 Colon cell line [AID69, Type: confirmatory]
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24
[SID505150]
NCI human tumor cell line growth inhibition assay. Data for the HCT-15 Colon cell line [AID71, Type: confirmatory]
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25
[SID505150]
NCI human tumor cell line growth inhibition assay. Data for the KM12 Colon cell line [AID73, Type: confirmatory]
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26
[SID505150]
NCI human tumor cell line growth inhibition assay. Data for the KM20L2 Colon cell line [AID75, Type: confirmatory]
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27
[SID505150]
NCI human tumor cell line growth inhibition assay. Data for the HCC-2998 Colon cell line [AID77, Type: confirmatory]
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28
[SID505150]
NCI human tumor cell line growth inhibition assay. Data for the HCT-116 Colon cell line [AID79, Type: confirmatory]
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29
[SID505150]
NCI human tumor cell line growth inhibition assay. Data for the SW-620 Colon cell line [AID81, Type: confirmatory]
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30
[SID505150]
NCI human tumor cell line growth inhibition assay. Data for the OVCAR-3 Ovarian cell line [AID99, Type: confirmatory]
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31
[SID505150]
NCI human tumor cell line growth inhibition assay. Data for the IGROV1 Ovarian cell line [AID101, Type: confirmatory]
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32
[SID505150]
NCI human tumor cell line growth inhibition assay. Data for the SK-OV-3 Ovarian cell line [AID103, Type: confirmatory]
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33
[SID505150]
NCI human tumor cell line growth inhibition assay. Data for the OVCAR-4 Ovarian cell line [AID105, Type: confirmatory]
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34
[SID505150]
NCI human tumor cell line growth inhibition assay. Data for the OVCAR-5 Ovarian cell line [AID107, Type: confirmatory]
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35
[SID505150]
NCI human tumor cell line growth inhibition assay. Data for the OVCAR-8 Ovarian cell line [AID109, Type: confirmatory]
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36
[SID505150]
NCI human tumor cell line growth inhibition assay. Data for the RPMI-8226 Leukemia cell line [AID113, Type: confirmatory]
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37
[SID505150]
NCI human tumor cell line growth inhibition assay. Data for the SR Leukemia cell line [AID115, Type: confirmatory]
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38
[SID505150]
NCI human tumor cell line growth inhibition assay. Data for the CCRF-CEM Leukemia cell line [AID119, Type: confirmatory]
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39
[SID505150]
NCI human tumor cell line growth inhibition assay. Data for the K-562 Leukemia cell line [AID121, Type: confirmatory]
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40
[SID505150]
NCI human tumor cell line growth inhibition assay. Data for the MOLT-4 Leukemia cell line [AID123, Type: confirmatory]
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41
[SID505150]
NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line [AID125, Type: confirmatory]
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42
[SID505150]
NCI human tumor cell line growth inhibition assay. Data for the A498 Renal cell line [AID129, Type: confirmatory]
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43
[SID505150]
NCI human tumor cell line growth inhibition assay. Data for the CAKI-1 Renal cell line [AID131, Type: confirmatory]
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44
[SID505150]
NCI human tumor cell line growth inhibition assay. Data for the RXF 393 Renal cell line [AID133, Type: confirmatory]
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45
[SID505150]
NCI human tumor cell line growth inhibition assay. Data for the 786-0 Renal cell line [AID137, Type: confirmatory]
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46
[SID505150]
NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line [AID139, Type: confirmatory]
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47
[SID505150]
NCI human tumor cell line growth inhibition assay. Data for the TK-10 Renal cell line [AID141, Type: confirmatory]
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48
[SID505150]
NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line [AID143, Type: confirmatory]
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49
[SID505150]
NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line [AID145, Type: confirmatory]
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50
[SID92763369]
Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis: Fluroescence-based biochemical high throughput Glycerophosphate Dehydrogenase-Triosephosphate Isomerase (GDH-TPI) assay to identify assay artifacts [AID652141, Type: screening]
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