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Indomethacin (CID 3715) - Compound BioActivity Data
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Filters: All Data » Active      
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BioActivity Outcomes:
Active(394)
 
 
Top Targets:
prostaglandin..(111)
 
 
p450(7)
 
 
NR LBD PPAR(6)
 
 
Aldo ket red(6)
 
 
NOS oxygenase..(3)
 
 
BioAssay Types:
Literature(351)
 
 
Confirmatory(5)
 
 
Summary(3)
 
 
Screening(2)
 
 
BioActivity Types:
IC50(279)
 
 
Potency(7)
 
 
Ki(6)
 
 
EC50(2)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 384    Data Row: 394   Total Pages: 8   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103163840]
EC50 0.00014Agonist activity at androgen receptor (unknown origin) expressed in HeLa cells co-expressing PSA-(ARE)4-Luc13 assessed as induction of DHT-induced luciferase activity after 20 mins by luciferase reporter gene assay [AID729242, Type: Literature]Androgen receptor [gi:113830]
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2
[SID103163840]
IC50 0.002In vitro inhibitory activity against human Prostaglandin G/H synthase 1 (COX-1) in U-937 cells [AID161480, Type: Literature]
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3
[SID103163840]
IC50 0.002In vitro inhibitory activity against Prostaglandin G/H synthase 1 in murine J774 cells [AID241917, Type: Literature]
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4
[SID103163840]
IC50 0.0029In vitro inhibitory effect on production of prostaglandin E2 (PGE2) in rat synovial cells. [AID228173, Type: Literature]
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5
[SID103163840]
IC50 0.003Inhibition of Prostaglandin G/H synthase 1 in U-937 cells from human histiocytic lymphoma [AID161499, Type: Literature]
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6
[SID103163840]
IC50 0.003Inhibition of arachidonic acid induced TXB2 generation in isolated human platelets (Prostaglandin G/H synthase 1 cell assay) [AID161503, Type: Literature]
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7
[SID103163840]
IC50 0.0036Concentration required to inhibit production of PGE-2 from THP-1 cells stimulated with A-23187 [AID209197, Type: Literature]
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8
[SID103163840]
IC50 0.0036Effect on production of eicosanoids from THP-1 cells stimulated with A-23187 using cellular assay on PGE-2, LTC-4 [AID209204, Type: Literature]
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9
[SID103163840]
IC50 0.004Inhibition of ovine COX1 [AID271286, Type: Literature]Prostaglandin G/H synthase 1 [gi:548481]
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10
[SID103163840]
IC50 0.0041Inhibition of bovine COX1 assessed as inhibition of calcium ionophore A23187-induced 12-hydroxyheptadecatrienoic acid formation by reverse-phase HPLC analysis [AID673509, Type: Literature]Prostaglandin G/H synthase 1 [gi:166897622]
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11
[SID103163840]
IC50 0.005Inhibition of COX1 assessed as TBX2 production in human whole blood [AID271283, Type: Literature]Prostaglandin G/H synthase 1 [gi:317373262]
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12
[SID103163840]
IC50 0.0059Inhibition of PGE-2 generation in LPS-stimulated human monocytes (Prostaglandin G/H synthase 2 cell assay) [AID162635, Type: Literature]
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13
[SID103163840]
IC50 0.006Inhibition of Prostaglandin G/H synthase 1 using whole cell assay [AID162009, Type: other]Prostaglandin G/H synthase 1 [gi:3914292]
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14
[SID103163840]
IC50 0.006In vitro inhibition of Prostaglandin G/H synthase 1 [AID162010, Type: other]
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15
[SID103163840]
IC50 0.006Inhibition of COX1 [AID313126, Type: Literature]
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16
[SID103163840]
IC50 0.006Inhibition of ovine COX1 after 5 mins [AID492859, Type: Literature]Prostaglandin G/H synthase 1 [gi:548481]
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17
[SID103163840]
IC50 0.006Inhibition of ovine COX-1 assessed as residual activity by measuring formation of 12-HHT from arachidonic acid by HPLC analysis [AID614601, Type: Literature]Prostaglandin G/H synthase 1 [gi:548481]
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18
[SID103163840]
IC50 0.0064IC50 value was determined against Prostaglandin G/H synthase 2 of J7744A.1 cell lines. [AID46861, Type: Literature]
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19
[SID103163840]
IC50 0.0064IC50 value against Prostaglandin G/H synthase 2 of murine J774A.1 cell line [AID46862, Type: Literature]
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20
[SID103163840]
IC50 0.0067Inhibition of ovine COX1 using arachidonic acid as substrate incubated for 1 min prior to substrate addition measured for 25 secs by TMPD-based chromogenic assay [AID695143, Type: Literature]Prostaglandin G/H synthase 1 [gi:548481]
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21
[SID103163840]
IC50 0.0082IC50 against Prostaglandin G/H synthase 1 from human platelet rich plasma [AID161471, Type: Literature]
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22
[SID103163840]
IC50 0.0082IC50 value against Prostaglandin G/H synthase 1 of human platelet rich plasma [AID161472, Type: Literature]
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23
[SID103163840]
IC50 0.009Inhibition of Prostaglandin G/H synthase 2 in 143.98.2 from human osteosarcoma cells [AID162636, Type: Literature]
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24
[SID103163840]
IC50 0.009In vitro inhibitory activity against human Prostaglandin G/H synthase 2 (COX-2) in 143982 cells [AID162489, Type: Literature]
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25
[SID103163840]
IC50 0.009In vitro inhibitory activity against Prostaglandin G/H synthase 2 in murine J774 cells [AID241918, Type: Literature]
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26
[SID103163840]
IC50 0.01Inhibition of COX2 [AID313125, Type: Literature]
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27
[SID103163840]
IC50 0.01Inhibition of human recombinant COX2 after 5 mins [AID492858, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
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28
[SID103163840]
IC50 0.01Inhibition of COX1 [AID403341, Type: Literature]
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29
[SID103163840]
IC50 0.01In vitro inhibition of Prostaglandin G/H synthase 2 [AID160598, Type: other]
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30
[SID103163840]
IC50 0.01Inhibition of Prostaglandin G/H synthase 2 [AID160597, Type: other]Prostaglandin G/H synthase 2 [gi:548484]
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31
[SID103163840]
IC50 0.01In vitro inhibitory activity against cyclooxygenase of human platelets was determined [AID160721, Type: Literature]
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32
[SID103163840]
IC50 0.01Inhibition of COX1 [AID642875, Type: other]
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33
[SID103163840]
IC50 0.01Inhibition of human recombinant COX-2 assessed as residual activity by measuring formation of 12-HHT from arachidonic acid by HPLC analysis [AID614602, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
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34
[SID103163840]
IC50 0.011Inhibitory activity against prostaglandin biosynthesis in stimulated chondrocyte cell culture [AID52139, Type: Literature]
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35
[SID103163840]
IC50 0.012Inhibition activity against recombinant human Prostaglandin G/H synthase 1 [AID161496, Type: Literature]
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36
[SID103163840]
IC50 0.0122IC50 against ovine Prostaglandin G/H synthase 1 [AID162015, Type: Literature]
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37
[SID103163840]
IC50 0.0122IC50 value against ovine Prostaglandin G/H synthase 1 [AID162016, Type: Literature]Prostaglandin G/H synthase 1 [gi:548481]
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38
[SID103163840]
IC50 0.015DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: other]Prostaglandin G/H synthase 1 [gi:317373262]
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39
[SID103163840]
IC50 0.017Inhibition of PGE-2 synthesis in bovine platelet suspension [AID213140, Type: Literature]Prostaglandin G/H synthase 2 [gi:3914301]
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40
[SID103163840]
IC50 0.017Inhibition of PGE-2 synthesis in bovine platelet suspension [AID213140, Type: Literature]Prostaglandin G/H synthase 1 [gi:166897622]
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41
[SID103163840]
IC50 0.018Tested in vitro for the ability to inhibit Prostaglandin G/H synthase 1 in chinese hamster ovary (CHO) cells [AID161676, Type: other]
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42
[SID103163840]
IC50 0.018In vitro inhibition of the production of PGE-2 in arachidonic acid stimulated chinese hamster ovary (CHO) cells transfected with human cyclooxygenase-1 [AID54534, Type: other]
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43
[SID103163840]
IC50 0.018In vitro inhibitory potency against human COX-1 in stably transfected chinese hamster ovary (CHO) cells [AID54540, Type: Literature]
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44
[SID103163840]
IC50 0.02Inhibition of COX-1 in U-937 (human lymphoma) cell microsomes. [AID54545, Type: Literature]
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45
[SID103163840]
IC50 0.02Inhibition of PGE-2 production in 3T3 (murine fibroblast) cell culture. [AID160863, Type: Literature]
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46
[SID103163840]
IC50 0.02Inhibition of Prostaglandin G/H synthase 1 was measured by the inhibition of PGE-2 produced by microsomes from U937 cells incubated in low concentration of arachidonic acid [AID161501, Type: Literature]
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47
[SID103163840]
IC50 0.02In vitro inhibitory activity against human whole cells Prostaglandin G/H synthase 1 [AID161485, Type: Literature]
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48
[SID103163840]
IC50 0.02Inhibition of COX1 (unknown origin)-mediated oxidation of N,N,N,Ntetramethyl-1,4-phenylenediamine using arachidonic acid as substrate by colorimetric assay [AID729252, Type: Literature]Prostaglandin G/H synthase 1 [gi:317373262]
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49
[SID103163840]
IC50 0.026In vitro inhibition of PGE-2 produced by arachidonic acid-stimulated CHO cells stably expressing human Prostaglandin G/H synthase 2 [AID162483, Type: Literature]
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50
[SID103163840]
IC50 0.026In vitro inhibition of the production of PGE-2 in arachidonic acid stimulated chinese hamster ovary (CHO) cells transfected with human cyclooxygenase-2 [AID54557, Type: other]
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