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Indomethacin (CID 3715) - Compound BioActivity Data
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BioActivity Outcomes:
Active(431)
 
 
Inactive(1776)
 
 
Inconclusive(243)
 
 
Unspecified(4531)
 
 
Top Targets:
prostaglandin..(225)
 
 
 
 
7TM GPCR Srx(51)
 
 
 
 
NR LBD PPAR(44)
 
 
 
 
 
p450(44)
 
 
 
 
 
7TM GPCR Srsx(39)
 
 
 
BioAssay Types:
Literature(2088)
 
 
 
 
 
Confirmatory(1235)
 
 
 
 
 
Screening(644)
 
 
 
 
Summary(73)
 
 
 
 
BioActivity Types:
Potency(951)
 
 
 
 
 
IC50(572)
 
 
 
 
 
Ki(25)
 
 
 
 
EC50(16)
 
 
 
 
 
Kd(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 6184    Data Row: 6981   Total Pages: 350   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103163840]
EC50 0.00014Agonist activity at androgen receptor (unknown origin) expressed in HeLa cells co-expressing PSA-(ARE)4-Luc13 assessed as induction of DHT-induced luciferase activity after 20 mins by luciferase reporter gene assay [AID729242, Type: Literature]Androgen receptor [gi:113830]
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2
[SID103163840]
IC50 0.002In vitro inhibitory activity against Prostaglandin G/H synthase 1 in murine J774 cells [AID241917, Type: Literature]
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3
[SID103163840]
IC50 0.002In vitro inhibitory activity against human Prostaglandin G/H synthase 1 (COX-1) in U-937 cells [AID161480, Type: Literature]
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4
[SID103163840]
IC50 0.0029In vitro inhibitory effect on production of prostaglandin E2 (PGE2) in rat synovial cells. [AID228173, Type: Literature]
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5
[SID103163840]
IC50 0.003Inhibition of Prostaglandin G/H synthase 1 in U-937 cells from human histiocytic lymphoma [AID161499, Type: Literature]
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6
[SID103163840]
IC50 0.003Inhibition of arachidonic acid induced TXB2 generation in isolated human platelets (Prostaglandin G/H synthase 1 cell assay) [AID161503, Type: Literature]
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7
[SID103163840]
IC50 0.0036Concentration required to inhibit production of PGE-2 from THP-1 cells stimulated with A-23187 [AID209197, Type: Literature]
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8
[SID103163840]
IC50 0.0036Effect on production of eicosanoids from THP-1 cells stimulated with A-23187 using cellular assay on PGE-2, LTC-4 [AID209204, Type: Literature]
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9
[SID103163840]
IC50 0.004Inhibition of ovine COX1 [AID271286, Type: Literature]Prostaglandin G/H synthase 1 [gi:548481]
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10
[SID103163840]
IC50 0.0041Inhibition of bovine COX1 assessed as inhibition of calcium ionophore A23187-induced 12-hydroxyheptadecatrienoic acid formation by reverse-phase HPLC analysis [AID673509, Type: Literature]Prostaglandin G/H synthase 1 [gi:166897622]
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11
[SID103163840]
IC50 0.005Inhibition of COX1 assessed as TBX2 production in human whole blood [AID271283, Type: Literature]Prostaglandin G/H synthase 1 [gi:317373262]
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12
[SID103163840]
IC50 0.0059Inhibition of PGE-2 generation in LPS-stimulated human monocytes (Prostaglandin G/H synthase 2 cell assay) [AID162635, Type: Literature]
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13
[SID103163840]
IC50 0.006In vitro inhibition of Prostaglandin G/H synthase 1 [AID162010, Type: confirmatory]
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14
[SID103163840]
IC50 0.006Inhibition of ovine COX-1 assessed as residual activity by measuring formation of 12-HHT from arachidonic acid by HPLC analysis [AID614601, Type: Literature]Prostaglandin G/H synthase 1 [gi:548481]
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15
[SID103163840]
IC50 0.006Inhibition of ovine COX1 after 5 mins [AID492859, Type: Literature]Prostaglandin G/H synthase 1 [gi:548481]
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16
[SID103163840]
IC50 0.006Inhibition of COX1 [AID313126, Type: Literature]
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17
[SID103163840]
IC50 0.006Inhibition of Prostaglandin G/H synthase 1 using whole cell assay [AID162009, Type: confirmatory]Prostaglandin G/H synthase 1 [gi:3914292]
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18
[SID103163840]
IC50 0.0064IC50 value was determined against Prostaglandin G/H synthase 2 of J7744A.1 cell lines. [AID46861, Type: Literature]
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19
[SID103163840]
IC50 0.0064IC50 value against Prostaglandin G/H synthase 2 of murine J774A.1 cell line [AID46862, Type: Literature]
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20
[SID103163840]
IC50 0.0067Inhibition of ovine COX1 using arachidonic acid as substrate incubated for 1 min prior to substrate addition measured for 25 secs by TMPD-based chromogenic assay [AID695143, Type: Literature]Prostaglandin G/H synthase 1 [gi:548481]
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