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indole-3-carbinol (CID 3712) - Compound BioActivity Data
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BioActivity Outcomes:
Active(25)
 
 
Inactive(690)
 
 
Inconclusive(62)
 
 
Unspecified(12)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
7TM GPCR Srsx(17)
 
 
NR LBD PPAR(13)
 
 
 
 
NR LBD AR(9)
 
 
 
NR LBD TR(9)
 
 
 
 
BioAssay Types:
Confirmatory(383)
 
 
 
 
 
Screening(335)
 
 
 
 
Summary(24)
 
 
 
 
Literature(15)
 
 
 
 
BioActivity Types:
Potency(349)
 
 
 
 
 
IC50(13)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 694    Data Row: 789   Total Pages: 16   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144214016]
Potency-Replicate_1 1.9331qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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2
[SID144214016]
Potency-Replicate_1 4.3647qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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3
[SID144214016]
AhR Potency (uM) 6.99184qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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4
[SID144214016]
Potency-Replicate_1 12.2998qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway [AID743191, Type: confirmatory]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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5
[SID57260065]
Potency 12.5893qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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6
[SID144214016]
Potency 17.2289qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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7
[SID144214016]
Ratio Potency (uM) 18.7806qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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8
[SID144214016]
Potency-Replicate_1 24.3365qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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9
[SID103398990]
Km 29Apparent Michaelis constant (Km) against Arylsulfotransferase (AST IV) [AID39219, Type: Literature]
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10
[SID144214016]
Potency-Replicate_1 30.6379qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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11
[SID144214016]
Potency 31.6228qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID720533, Type: confirmatory]
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12
[SID144214016]
Potency 31.6228qHTS for Inhibitors of binding or entry into cells for Marburg Virus [AID720532, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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13
[SID144214016]
Potency 38.5708qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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14
[SID144214016]
Ratio Potency (uM) 43.6621qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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15
[SID144214016]
Potency-Replicate_1 48.5577qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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16
[SID144214016]
Potency-Replicate_1 54.4827qHTS assay to identify aromatase inhibitors [AID743083, Type: confirmatory]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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17
[SID144214016]
Potency-Replicate_1 54.4827qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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18
[SID144214016]
Potency-Replicate_1 54.4827qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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19
[SID17388972]
Potency 66.8242qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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20
[SID144214016]
Potency-Replicate_1 68.5896qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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21
[SID57260065]
Luminescence-based primary cell-based high throughput screening assay to identify activators of the Aryl Hydrocarbon Receptor (AHR) [AID2796, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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22
[SID57260065]
Luminescence-based cell-based primary high throughput screening assay to identify activators of the DAF-12 from the parasite H. contortus (hcDAF-12) [AID652067, Type: screening]Protein DAF-12, isoform a [Caenorhabditis elegans] [gi:71987181]
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23
[SID144214016]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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24
[SID144214016]
qHTS assay to identify aromatase inhibitors: Summary [AID743139, Type: summary]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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25
[SID144214016]
qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway: Summary [AID743199, Type: summary]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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26
[SID103398990]
IC50 309Antiproliferative activity against human 1321N1 cells assessed as inhibition of cell growth after 48 hrs by MTS assay [AID738621, Type: Literature]
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27
[SID103398990]
IC50 526Antiproliferative activity against human U87MG cells assessed as inhibition of cell growth after 48 hrs by MTS assay [AID738620, Type: Literature]
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28
[SID17388972]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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29
[SID103398990]
TP_TRANSPORTER: Branched DNA assay in vivo SD rat, liver [AID679334, Type: other]Multidrug resistance protein 1 [gi:1170902]
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30
[SID103398990]
TP_TRANSPORTER: Branched DNA assay in vivo SD rat, kidney [AID678992, Type: other]Canalicular multispecific organic anion transporter 1 [gi:3219824]
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31
[SID103398990]
Maximal velocity (Vmax) against Arylsulfotransferase (AST IV) [AID39220, Type: Literature]
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32
[SID103398990]
Ratio of kcat/Km determined for catalytic efficiency in sulfonation against AST IV [AID229377, Type: Literature]
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33
[SID103398990]
TP_TRANSPORTER: Northern blot in vivo SD rat, liver [AID679494, Type: other]Solute carrier organic anion transporter family member 1A4 [gi:3914190]
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34
[SID103398990]
TP_TRANSPORTER: Western in vivo SD rat, liver [AID682136, Type: other]Solute carrier organic anion transporter family member 1A4 [gi:3914190]
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35
[SID57260065]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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36
[SID103398990]
Inhibition of electric eel AChE at 2 mg/ml by Ellman's method [AID697852, Type: Literature]Acetylcholinesterase [gi:14916521]
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37
[SID103398990]
Inhibition of horse BChE at 2 mg/ml by Ellman's method [AID697853, Type: Literature]Cholinesterase [gi:21362409]
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38
[SID57260065]
Potency 25.1189qHTS Assay to Find Inhibitors of Pin1 [AID504891, Type: confirmatory]peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [Homo sapiens] [gi:5453898]
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39
[SID57260065]
Potency 35.4813qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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40
[SID144214016]
Potency-Replicate_1 61.1306qHTS assay to identify small molecule agonists of the thyroid receptor (TR) signaling pathway [AID743066, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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41
[SID57260065]
Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors of ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (ASAP1) [AID624377, Type: screening]arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 2 [Homo sapiens] [gi:351542238]
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42
[SID57260065]
Mycobacterium tuberculosis BioA enzyme inhibitor Measured in Biochemical System Using Plate Reader - 2163-01_Inhibitor_SinglePoint_HTS_Activity [AID602481, Type: screening]bioA [Mycobacterium tuberculosis UT205] [gi:378544807]
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43
[SID144214016]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the glucocorticoid receptor (GR) signaling pathway: Summary [AID720719, Type: summary]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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44
[SID57260065]
C-LANA FP assay Measured in Biochemical System Using Plate Reader - 2117-01_Inhibitor_SinglePoint_HTS_Activity [AID504423, Type: screening]LANA [Human herpesvirus 8] [gi:312275222]
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45
[SID17388972]
Potency qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2) [AID881, Type: confirmatory]Arachidonate 15-lipoxygenase B [gi:317373425]
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46
[SID57260065]
Potency qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen [AID720709, Type: confirmatory]Rap guanine nucleotide exchange factor 3 [gi:317373593]
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47
[SID57260065]
Potency qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen [AID720707, Type: confirmatory]Rap guanine nucleotide exchange factor 3 [gi:317373593]
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48
[SID17388972]
Potency qHTS assay for small molecule agonists of retinoid X receptor alpha signaling [AID588544, Type: confirmatory]retinoid X nuclear receptor alpha [Homo sapiens] [gi:325495497]
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49
[SID17388972]
Potency qHTS assay for small molecule antagonists of retinoid X receptor alpha signaling [AID588546, Type: confirmatory]retinoid X nuclear receptor alpha [Homo sapiens] [gi:325495497]
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50
[SID17388972]
Potency qHTS assay for small molecule antagonists of farnesoid X receptor signaling [AID588526, Type: confirmatory]farnesoid X nuclear receptor [Homo sapiens] [gi:325495553]
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