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Imipramine (CID 3696) - Compound BioActivity Data
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BioActivity Outcomes:
Active(154)
 
 
Inactive(348)
 
 
Inconclusive(131)
 
 
Unspecified(1807)
 
 
Top Targets:
p450(28)
 
 
 
 
GT1 Gtf like(14)
 
 
7TM GPCR Srx(13)
 
 
 
 
MFS(10)
 
 
 
NR LBD GR(8)
 
 
 
BioAssay Types:
Literature(615)
 
 
 
 
 
Confirmatory(349)
 
 
 
 
Summary(24)
 
 
 
Screening(11)
 
 
BioActivity Types:
Potency(317)
 
 
 
 
IC50(103)
 
 
 
 
 
Ki(29)
 
 
 
EC50(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2228    Data Row: 2440   Total Pages: 49   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103164240]
IC50 6e-05Compound tested for its inhibitory activity against Histamine H1 receptor [AID87513, Type: Literature]
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2
[SID103164240]
Ki 0.00077Displacement of [3H]imipramine from human 5HT transporter [AID612016, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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3
[SID103164240]
IC50 0.0017Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain [AID91721, Type: Literature]
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4
[SID103164240]
IC50 0.0044Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA [AID255079, Type: Literature]Adenosine receptor A3 [gi:1351831]
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5
[SID103164240]
Ki 0.005Binding affinity to Serotonin transporter using [3H]-paroxetine as radioligand in stably transfected NIH3T3 cells [AID204217, Type: Literature]
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6
[SID103164240]
Ki 0.005Binding affinity towards Serotonin transporter using [3H]paroxetine as radioligand [AID204880, Type: Literature]
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7
[SID103164240]
IC50 0.0069Displacement of radiolabeled imipramine from human SERT [AID346472, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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8
[SID103164240]
IC50 0.0073Inhibition of human 5-HT transporter [AID566273, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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9
[SID103164240]
Ki 0.00757Inhibition of [3H]serotonin reuptake at serotonin transporter [AID431484, Type: Literature]
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10
[SID103164240]
IC50 0.008Inhibition of [3H]5HT uptake at human SERT expressed in HEK293 cells [AID351887, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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11
[SID103164240]
Ki 0.012Inhibition of uptake of tritiated norepinephrine (NE) in rat synaptosomes [AID196062, Type: Literature]
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12
[SID103164240]
Ki 0.012Binding affinity against imipramine receptor was determined in homogenized rat cortex tissue using [3H]-imipramine as radioligand [AID91833, Type: Literature]
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13
[SID103164240]
Ki 0.012Tested in vitro for norepinephrine (NE) neuronal uptake inhibition [AID134216, Type: Literature]
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14
[SID103164240]
Ki 0.016Binding affinity to Norepinephrine transporter using [3H]-nisoxatine as radioligand in stably transfected NIH3T3 cells [AID145696, Type: Literature]
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15
[SID103164240]
Ki 0.016Binding affinity towards Norepinephrine transporter using [3H]nisoxitine as radioligand [AID145895, Type: Literature]
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16
[SID103164240]
Ki 0.0203Displacement of [3H]citalopram from serotonin transporter [AID338160, Type: Literature]
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17
[SID103164240]
Ki 0.023Binding affinity towards 5-hydroxytryptamine 2 receptor [AID5241, Type: Literature]
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18
[SID103164240]
IC50 0.027Inhibition of Norepinephrine uptake from rat diencephalon-midbrain [AID179941, Type: Literature]
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19
[SID103164240]
IC50 0.029Inhibition of human SERT expressed in HEK293-MSR cells by 5-HT uptake assay [AID729797, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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20
[SID103164240]
IC50 0.03Inhibition of [3H]norepinephrine uptake into rat brain synaptosomes in vitro;Values ranges from : 0.01-0.07 [AID196031, Type: Literature]
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21
[SID103164240]
IC50 0.03Binding affinity towards histamine receptor by inhibiting specific binding of [3H]-mepyramine (3 nM) in vitro to membranes of rat brain without cerebellum [AID90053, Type: Literature]
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22
[SID103164240]
IC50 0.04In vitro inhibition of norepinephrine (NE) uptake in synaptosomal preparation of rat brain [AID196022, Type: Literature]
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23
[SID103164240]
Ki 0.0418Inhibition the uptake of tritiated serotonin (5-HT) by the serotonin transporter SERT in rat synaptosomes [AID196063, Type: Literature]
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24
[SID103164240]
Ki 0.042Tested in vitro for serotonin(5-HT) neuronal uptake inhibition [AID134217, Type: Literature]
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25
[SID103164240]
IC50 0.044Compound was tested for its inhibitory activity against 5-hydroxytryptamine receptor [AID6418, Type: Literature]5-hydroxytryptamine receptor 5A [gi:543729]
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26
[SID103164240]
IC50 0.044Compound was tested for its inhibitory activity against 5-hydroxytryptamine receptor [AID6418, Type: Literature]5-hydroxytryptamine receptor 5B [gi:543730]
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27
[SID103164240]
IC50 0.044Compound was tested for its inhibitory activity against 5-hydroxytryptamine receptor [AID6418, Type: Literature]5-hydroxytryptamine receptor 7 [gi:461440]
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28
[SID103164240]
IC50 0.044Compound was tested for its inhibitory activity against 5-hydroxytryptamine receptor [AID6418, Type: Literature]5-hydroxytryptamine receptor 6 [gi:1168221]
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29
[SID103164240]
IC50 0.044Compound was tested for its inhibitory activity against 5-hydroxytryptamine receptor [AID6418, Type: Literature]5-hydroxytryptamine receptor 3A [gi:1168223]
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30
[SID103164240]
IC50 0.044Compound was tested for its inhibitory activity against 5-hydroxytryptamine receptor [AID6418, Type: Literature]5-hydroxytryptamine receptor 1F [gi:398968]
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31
[SID103164240]
IC50 0.044Compound was tested for its inhibitory activity against 5-hydroxytryptamine receptor [AID6418, Type: Literature]5-hydroxytryptamine receptor 2B [gi:398970]
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32
[SID103164240]
IC50 0.044Compound was tested for its inhibitory activity against 5-hydroxytryptamine receptor [AID6418, Type: Literature]5-hydroxytryptamine receptor 2A [gi:112808]
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33
[SID103164240]
IC50 0.044Compound was tested for its inhibitory activity against 5-hydroxytryptamine receptor [AID6418, Type: Literature]5-hydroxytryptamine receptor 1A [gi:112812]
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34
[SID103164240]
IC50 0.044Compound was tested for its inhibitory activity against 5-hydroxytryptamine receptor [AID6418, Type: Literature]5-hydroxytryptamine receptor 1B [gi:112815]
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35
[SID103164240]
IC50 0.044Compound was tested for its inhibitory activity against 5-hydroxytryptamine receptor [AID6418, Type: Literature]5-hydroxytryptamine receptor 2C [gi:112817]
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36
[SID103164240]
IC50 0.044Compound was tested for its inhibitory activity against 5-hydroxytryptamine receptor [AID6418, Type: Literature]5-hydroxytryptamine receptor 1D [gi:112820]
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37
[SID103164240]
IC50 0.044Compound was tested for its inhibitory activity against 5-hydroxytryptamine receptor [AID6418, Type: Literature]5-hydroxytryptamine receptor 4 [gi:2494928]
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38
[SID103164240]
IC50 0.044Compound was tested for its inhibitory activity against 5-hydroxytryptamine receptor [AID6418, Type: Literature]5-hydroxytryptamine receptor 3B [gi:81868595]
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39
[SID103164240]
IC50 0.046Compound was tested for its inhibitory activity against Noradrenaline receptor [AID147591, Type: Literature]
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40
[SID103164240]
Ki 0.046In vitro binding affinity at Alpha-1 adrenergic receptor by radioligand binding assay using [3H]prazosin [AID35284, Type: other]
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41
[SID103164240]
IC50 0.06Inhibition of norepinephrine uptake in synaptosomal preparation fro rat hypothalamus, using [3H]norepinephrine [AID179973, Type: Literature]
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42
[SID103164240]
Ki 0.065Binding affinity against Muscarinic acetylcholine receptor was determined in homogenized rat cortex tissue using [3H]N-methylscopolamine as radioligand [AID142220, Type: Literature]
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43
[SID103164240]
IC50 0.074Inhibition of [3H]norepinephrine uptake at human NET expressed in HEK293 cells [AID351894, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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44
[SID103164240]
IC50 0.085Inhibitory activity against uptake of [3H]norepinephrine into rat brain synaptosomes. [AID180151, Type: Literature]
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45
[SID103164240]
Ki 0.094Binding affinity towards 5-hydroxytryptamine 2A receptor using [3H]ketanserin [AID5355, Type: Literature]
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46
[SID103164240]
IC50 0.105Concentration required for its norepinephrine reuptake inhibitory activity in synoptosomal rat hypothalamic preparations [AID179398, Type: other]
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47
[SID103164240]
IC50 0.12Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes [AID180133, Type: Literature]
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48
[SID103164240]
IC50 0.13Inhibition of [3H]dopamine uptake into rat brain synaptosomes in vitro;Values ranges from : 0.09-0.18 [AID196028, Type: Literature]
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49
[SID103164240]
Ki 0.16Displacement of [3H]ketanserin from 5-hydroxytryptamine 2A receptor expressed NIH3T3 cells [AID5444, Type: Literature]
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50
[SID103164240]
Ki 0.16Binding affinity to 5-hydroxytryptamine 2C receptor using [3H]Mesulergine as radioligand in stably transfected NIH3T3 cells [AID5679, Type: Literature]
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