Bookmark and Share
Imipramine (CID 3696) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(165)
 
 
Inactive(361)
 
 
Inconclusive(123)
 
 
Unspecified(1503)
 
 
Top Targets:
p450(28)
 
 
 
 
7tm 4(23)
 
 
 
 
GT1 Gtf like(14)
 
 
SLC6sbd SERT(10)
 
 
MFS(10)
 
 
 
BioAssay Types:
Literature(668)
 
 
 
 
 
Confirmatory(354)
 
 
 
 
Summary(24)
 
 
 
Screening(11)
 
 
BioActivity Types:
Potency(319)
 
 
 
 
IC50(110)
 
 
 
 
 
Ki(29)
 
 
 
EC50(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1939    Data Row: 2152   Total Pages: 108   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103164240]
IC50 6e-05Compound tested for its inhibitory activity against Histamine H1 receptor [AID87513, Type: Literature]
View
2
[SID103164240]
Ki 0.00077Displacement of [3H]imipramine from human 5HT transporter [AID612016, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
View
3
[SID103164240]
IC50 0.0011Binding affinity to human 5-HT transporter by radioligand displacement assay [AID751835, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
View
4
[SID103164240]
IC50 0.0017Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain [AID91721, Type: Literature]
View
5
[SID103164240]
IC50 0.002Binding affinity to human serotonin 5-HT transporter by radioligand displacement assay [AID752199, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
View
6
[SID103164240]
IC50 0.0035Binding affinity to SERT (unknown origin) by radioligand binding assay [AID1054118, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
View
7
[SID103164240]
IC50 0.0044Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA [AID255079, Type: Literature]Adenosine receptor A3 [gi:1351831]
View
8
[SID103164240]
Ki 0.005Binding affinity to Serotonin transporter using [3H]-paroxetine as radioligand in stably transfected NIH3T3 cells [AID204217, Type: Literature]
View
9
[SID103164240]
Ki 0.005Binding affinity towards Serotonin transporter using [3H]paroxetine as radioligand [AID204880, Type: Literature]
View
10
[SID103164240]
IC50 0.0068Displacement of [3H]imipramin from human recombinant SERT over-expressed in HEK293 cells [AID773434, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
View
11
[SID103164240]
IC50 0.0069Displacement of radiolabeled imipramine from human SERT [AID346472, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
View
12
[SID103164240]
IC50 0.0073Inhibition of human 5-HT transporter [AID566273, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
View
13
[SID103164240]
Ki 0.00757Inhibition of [3H]serotonin reuptake at serotonin transporter [AID431484, Type: Literature]
View
14
[SID103164240]
IC50 0.008Inhibition of [3H]5HT uptake at human SERT expressed in HEK293 cells [AID351887, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
View
15
[SID103164240]
Ki 0.012Inhibition of uptake of tritiated norepinephrine (NE) in rat synaptosomes [AID196062, Type: Literature]
View
16
[SID103164240]
Ki 0.012Tested in vitro for norepinephrine (NE) neuronal uptake inhibition [AID134216, Type: Literature]
View
17
[SID103164240]
Ki 0.012Binding affinity against imipramine receptor was determined in homogenized rat cortex tissue using [3H]-imipramine as radioligand [AID91833, Type: Literature]
View
18
[SID103164240]
Ki 0.016Binding affinity to Norepinephrine transporter using [3H]-nisoxatine as radioligand in stably transfected NIH3T3 cells [AID145696, Type: Literature]
View
19
[SID103164240]
Ki 0.016Binding affinity towards Norepinephrine transporter using [3H]nisoxitine as radioligand [AID145895, Type: Literature]
View
20
[SID103164240]
Ki 0.0203Displacement of [3H]citalopram from serotonin transporter [AID338160, Type: Literature]
View