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ifenprodil (CID 3689) - Compound BioActivity Data
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BioActivity Outcomes:
Active(92)
 
 
Inactive(220)
 
 
Inconclusive(65)
 
 
Unspecified(24)
 
 
Top Targets:
PBP1 iGluR NM..(10)
 
 
 
NR LBD PPAR(8)
 
 
NR LBD AR(7)
 
 
 
NR LBD ER(7)
 
 
 
NR LBD VDR(7)
 
 
BioAssay Types:
Confirmatory(213)
 
 
 
 
Literature(136)
 
 
 
 
 
Summary(24)
 
 
 
Screening(23)
 
 
BioActivity Types:
Potency(227)
 
 
 
 
IC50(25)
 
 
 
 
Ki(19)
 
 
EC50(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 291    Data Row: 401   Total Pages: 21   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID124960908]
IC50 0.00073Neuroprotective activity in human SH-SY5Y cells assessed as protection against NMDA-induced cell death after 6 hrs by MTS assay [AID707048, Type: Literature]
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2
[SID124960908]
Ki 0.002Displacement of [3H](+)-pentazocine from sigma1 receptor in rat liver membrane by liquid scintillation counting [AID427337, Type: Literature]Sigma non-opioid intracellular receptor 1 [gi:81882051]
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3
[SID124960908]
Ki 0.002Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membrane without cerebellum [AID348122, Type: Literature]Sigma non-opioid intracellular receptor 1 [gi:81862796]
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4
[SID124960908]
Ki 0.0023Displacement of [3H]-DTG from sigma 2-type opioid receptor in rat liver membrane in presence of (+)-pentazocine [AID348123, Type: Literature]
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5
[SID124960908]
Ki 0.00271Inhibition of [3H]-emopamil binding to Sterol delta 8-delta 7 isomerase in guinea pig liver membrane [AID205913, Type: Literature]3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase [gi:18202586]
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6
[SID124960908]
IC50 0.0039Compound was tested for the binding affinity against sigma receptor by using [3H]-+3PPP as radioligand [AID229210, Type: Literature]
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7
[SID124960908]
Ki 0.0047Displacement of [3H](+/-)-emopamil from delta8-delta7 sterol isomerase (SI) site in guinea pig liver membranes [AID256860, Type: Literature]3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase [gi:18202586]
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8
[SID124960908]
Ki 0.0049Inhibition of [3H]- ifenprodil binding against Sigma opioid receptor type 2 from rat brain [AID204312, Type: Literature]Sigma non-opioid intracellular receptor 1 [gi:81882051]
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9
[SID124960908]
Ki 0.01Displacement of [3H]ifenprodil from human recombinant NR1-1a/NR2B receptor expressed in mouse L(tk-) cells after 120 mins by scintillation counting [AID538755, Type: Literature]Glutamate receptor ionotropic, NMDA 2B [gi:14548162]
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10
[SID124960908]
Ki 0.01Displacement of [3H]ifenprodil from human recombinant NR1-1a/NR2B receptor expressed in mouse L(tk-) cells after 120 mins by scintillation counting [AID538755, Type: Literature]Glutamate receptor ionotropic, NMDA 1 [gi:548377]
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11
[SID124960908]
Ki 0.0102Displacement of [3H](+/-)-emopamil from EBP in Dunkin guinea pig liver membrane by radioreceptor binding assay [AID437518, Type: Literature]3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase [gi:18202586]
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12
[SID124960908]
Ki 0.011Displacement of [3H]ifenprodil from rat brain membrane NR2B receptor [AID332028, Type: Literature]Glutamate receptor ionotropic, NMDA 2B [gi:548372]
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13
[SID124960908]
Ki 0.015Displacement of [3H]-emopamil from delta(8)-delta(7) sterol isomerase in guinea pig liver membranes [AID634764, Type: Literature]3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase [gi:18202586]
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14
[SID124960908]
Ki 0.0164Displacement of [3H](-)-(S)-emopamil from EBP in guinea pig liver membrane [AID348121, Type: Literature]3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase [gi:18202586]
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15
[SID124960908]
Ki 0.0198Displacement of [3H]emopamil from Delta-(8)-Delta-(7) sterol isomerase in guinea pig liver membrane [AID297869, Type: Literature]3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase [gi:18202586]
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16
[SID124960908]
Ki 0.02Displacement of [3H]ifenprodil from NR2B receptor in rat cortical synaptic membranes [AID526573, Type: Literature]Glutamate receptor ionotropic, NMDA 2B [gi:548372]
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17
[SID124960908]
IC50 0.02Displacement of [3H]ifenprodil from NMDA receptor GluN2B subunit in Wistar rat cerebral cortex after 120 mins [AID709978, Type: Literature]Glutamate receptor ionotropic, NMDA 2B [gi:548372]
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18
[SID124960908]
IC50 0.0205Displacement of [3H]ifenprodil from NMDA NR2B receptor in Wistar rat cerebral cortex membrane [AID392779, Type: Literature]Glutamate receptor ionotropic, NMDA 2B [gi:548372]
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19
[SID124960908]
Ki 0.0258Antiproliferative activity against human PC3 cells expressing EBP after 48 hrs by MTT assay [AID348124, Type: Literature]
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20
[SID124960908]
Ki 0.029Displacement of [3H]Ifenprodil from NMDAR-2B in Sprague-Dawley rat frontal cortex homogenates after 2 hrs by liquid scintillation counting [AID707052, Type: Literature]Glutamate receptor ionotropic, NMDA 2B [gi:548372]
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