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idebenone (CID 3686) - Compound BioActivity Data
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BioActivity Outcomes:
Active(55)
 
 
Inactive(485)
 
 
Inconclusive(64)
 
 
Unspecified(362)
 
 
Top Targets:
7TM GPCR Srx(32)
 
 
 
 
7TM GPCR Srsx(27)
 
 
 
NR LBD PPAR(14)
 
 
 
 
p450(10)
 
 
 
 
NR LBD ER(9)
 
 
 
 
BioAssay Types:
Confirmatory(324)
 
 
 
 
 
Screening(248)
 
 
 
 
Literature(201)
 
 
 
 
 
Summary(24)
 
 
 
 
BioActivity Types:
Potency(180)
 
 
 
 
IC50(155)
 
 
 
 
EC50(12)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 843    Data Row: 966   Total Pages: 49   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103556242]
EC50 0.551Cytoprotective activity against BSO-induced cell death in human Friedreich's ataxia lymphocytes preincubated for 12 hrs prior to BSO-treatment measured after 48 hrs by luminescence assay [AID760292, Type: Literature]
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2
[SID103556242]
EC50 0.592Cytoprotective activity against BSO-induced human FRDA primary patient fibroblasts compound pretreated 12 hrs prior to BSO-induction measured after 48 hrs by calcein-AM-based cell viability assay [AID642426, Type: Literature]
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3
[SID103556242]
EC50 0.73Cytoprotection in diethyl maleate-treated human Friedreich's ataxia lymphocytes incubated for 17 hrs before diethyl maleate challenge by trypan blue dye exclusion method [AID703749, Type: Literature]
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4
[SID103556242]
IC50 0.8DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625247, Type: confirmatory]Cytochrome P450 2C19 [gi:60416369]
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5
[SID103556242]
EC50 0.85Cytoprotectant activity against L-buthionine-(S,R)-sulfoximine-induced cell death in Friedreich ataxia patient fibroblasts assessed as increase of cell viability [AID611404, Type: Literature]
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6
[SID103556242]
IC50 1.3Inhibition of NADH-induced lipid peroxidation in rat brain microsome [AID312786, Type: Literature]
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7
[SID103556242]
IC50 3DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625249, Type: confirmatory]Cytochrome P450 2D6 [gi:84028191]
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8
[SID26719872]
Potency 4.4563qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-biphosphate Aldolase In Complex With Phosphoglycolohydroxamate [gi:122920737]
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9
[SID144205417]
Potency 4.7318qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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10
[SID103556242]
IC50 5DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625248, Type: confirmatory]Cytochrome P450 2C9 [gi:6686268]
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11
[SID103556242]
IC50 5.8Inhibition of NADH-ubiquinone oxidoreductase activity in bovine heart submitochondrial particles using coenzyme Q1 as substrate after 5 mins by spectrophotometric analysis [AID738411, Type: Literature]
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12
[SID144205417]
Potency 5.9569qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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13
[SID103556242]
IC50 6Inhibition of NADH-ubiquinone oxidoreductase in bovine heart mitochondria after 5 mins by spectrophotometric analysis [AID754331, Type: Literature]
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14
[SID29216196]
Potency 6.012Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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15
[SID103556242]
IC50 7DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) [AID625251, Type: confirmatory]Cytochrome P450 3A4 [gi:116241312]
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16
[SID144205417]
Potency-Replicate_1 8.4127qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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17
[SID144205417]
Potency-Replicate_1 10.5909qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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18
[SID144205417]
Potency-Replicate_1 13.3332qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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19
[SID144205417]
Potency-Replicate_1 16.9301qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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20
[SID144205417]
Ratio Potency (uM) 18.8336qHTS assay for small molecule agonists of the p53 signaling pathway: Summary [AID720552, Type: summary]Cellular tumor antigen p53 [gi:269849759]
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