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idebenone (CID 3686) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(45)
 
 
Inactive(461)
 
 
Inconclusive(71)
 
 
Unspecified(176)
 
 
Top Targets:
7TM GPCR Srx(33)
 
 
 
 
7TM GPCR Srsx(27)
 
 
 
NR LBD PPAR(14)
 
 
 
p450(10)
 
 
 
 
NR LBD ER(9)
 
 
 
 
BioAssay Types:
Screening(247)
 
 
 
 
Confirmatory(207)
 
 
 
 
Literature(125)
 
 
 
 
 
Summary(24)
 
 
 
 
BioActivity Types:
Potency(179)
 
 
 
 
IC50(154)
 
 
 
 
EC50(11)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 636    Data Row: 753   Total Pages: 16   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103556242]
EC50 0.592Cytoprotective activity against BSO-induced human FRDA primary patient fibroblasts compound pretreated 12 hrs prior to BSO-induction measured after 48 hrs by calcein-AM-based cell viability assay [AID642426, Type: Literature]
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2
[SID103556242]
EC50 0.73Cytoprotection in diethyl maleate-treated human Friedreich's ataxia lymphocytes incubated for 17 hrs before diethyl maleate challenge by trypan blue dye exclusion method [AID703749, Type: Literature]
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3
[SID103556242]
IC50 0.8DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625247, Type: other]Cytochrome P450 2C19 [gi:60416369]
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4
[SID103556242]
EC50 0.85Cytoprotectant activity against L-buthionine-(S,R)-sulfoximine-induced cell death in Friedreich ataxia patient fibroblasts assessed as increase of cell viability [AID611404, Type: Literature]
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5
[SID103556242]
IC50 1.3Inhibition of NADH-induced lipid peroxidation in rat brain microsome [AID312786, Type: Literature]
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6
[SID103556242]
IC50 3DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625249, Type: other]Cytochrome P450 2D6 [gi:84028191]
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7
[SID26719872]
Potency 4.4563qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-biphosphate Aldolase In Complex With Phosphoglycolohydroxamate [gi:122920737]
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8
[SID144205417]
Potency 4.7318qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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9
[SID103556242]
IC50 5DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625248, Type: other]Cytochrome P450 2C9 [gi:6686268]
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10
[SID103556242]
IC50 5.8Inhibition of NADH-ubiquinone oxidoreductase activity in bovine heart submitochondrial particles using coenzyme Q1 as substrate after 5 mins by spectrophotometric analysis [AID738411, Type: Literature]
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11
[SID144205417]
Potency 5.9569qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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12
[SID29216196]
Potency 6.012Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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13
[SID103556242]
IC50 7DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) [AID625251, Type: other]Cytochrome P450 3A4 [gi:116241312]
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14
[SID144205417]
Potency-Replicate_1 8.4127qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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15
[SID144205417]
Potency-Replicate_1 10.5909qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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16
[SID144205417]
Potency-Replicate_1 13.3332qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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17
[SID144205417]
Potency-Replicate_1 18.8336qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743042, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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18
[SID144205417]
Potency-Replicate_1 18.8336qHTS assay for small molecule agonists of the p53 signaling pathway [AID651631, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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19
[SID144205417]
Ratio Potency (uM) 18.8336qHTS assay for small molecule agonists of the p53 signaling pathway: Summary [AID720552, Type: summary]Cellular tumor antigen p53 [gi:269849759]
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20
[SID170465611]
Potency-Replicate_1 23.7083qHTS assay to identify small molecule agonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743224, Type: confirmatory]
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21
[SID144205417]
AR Potency (uM) 23.7101qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line: Summary [AID743054, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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22
[SID170465611]
Potency-Replicate_1 23.9145qHTS assay to identify small molecule antagonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743225, Type: confirmatory]
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23
[SID144205417]
Potency-Replicate_1 26.6032qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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24
[SID170465611]
Potency-Replicate_1 29.847qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743211, Type: confirmatory]
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25
[SID144205417]
Potency-Replicate_1 29.8493qHTS assay to identify aromatase inhibitors [AID743083, Type: confirmatory]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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26
[SID144205417]
Potency-Replicate_1 29.8493qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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27
[SID144205417]
Potency-Replicate_1 29.8493qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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28
[SID103556242]
IC50 31.5Inhibition of Fe2+-induced lipid peroxidation in rat brain homogenate [AID312787, Type: Literature]
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29
[SID103556242]
IC50 36Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay [AID729236, Type: Literature]
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30
[SID29216196]
Potency 44.6684Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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31
[SID26719872]
Potency 50.1187qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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32
[SID26719872]
EC50 uHTS luminescence assay for the identification of compounds that inhibit NOD1 [AID1578, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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33
[SID103060386]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human cholinergic receptor, muscarinic 5 (CHRM5) [AID624040, Type: screening]muscarinic acetylcholine receptor M5 [Homo sapiens] [gi:7108336]
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34
[SID26719872]
qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Coupling assay counterscreen [AID2472, Type: screening]glyceraldehyde-3-phosphate dehydrogenase isoform 1 [Homo sapiens] [gi:7669492]
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35
[SID26719872]
uHTS Identification of Diaphorase Inhibitors and Chemcical Oxidizers: Counter Screen for Diaphorase-based Primary Assays [AID1217, Type: screening]Dihydrolipoamide dehydrogenase [Homo sapiens] [gi:17391426]
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36
[SID26719872]
uHTS of Mcl-1/Noxa interaction inhibitors [AID1022, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
View
37
[SID26719872]
IC50 HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. [AID1209, Type: confirmatory]MPI protein [Homo sapiens] [gi:16878311]
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38
[SID26719872]
IC50 HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay using a high concentration of mannose 6-phosphate [AID1220, Type: confirmatory]MPI protein [Homo sapiens] [gi:16878311]
View
39
[SID26719872]
Luminescence-based primary biochemical high throughput screening assay to identify inhibitors of the Heat Shock Protein 90 (HSP90) [AID1789, Type: screening]HSP90AA1 protein [Homo sapiens] [gi:83318444]
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40
[SID103060386]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human cholinergic receptor, muscarinic 4 (CHRM4) [AID624125, Type: screening]muscarinic acetylcholine receptor M4 [Homo sapiens] [gi:52426748]
View
41
[SID103556242]
Inhibition of diethyl maleate-induced ROS production in human CCRF-CEM cells at 0.25 to 2.5 uM incubated for 16 hrs by DCFH-DA dye staining based FACS method [AID703756, Type: Literature]
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42
[SID103556242]
Solubility of the compound in 0.1 M phosphate buffer at 600 uM at pH 7.4 after 24 hrs by LC/MS/MS analysis [AID539464, Type: Literature]
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43
[SID103556242]
Solubility of the compound in water [AID539470, Type: Literature]
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44
[SID26719872]
Counter Screen for Glucose-6-Phosphate Dehydrogenase-based Primary Assay [AID1020, Type: screening]glucose-6-phosphate dehydrogenase [Leuconostoc mesenteroides] [gi:149631]
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45
[SID26719872]
Antagonist of Human D 1 Dopamine Receptor: qHTS [AID504652, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
View
46
[SID103556242]
IC50 70Inhibition of tPMET complex in human mitochondrial gene-knockout HL60 cells after 30 mins by WST-1/mPMS reduction assay [AID729237, Type: Literature]
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47
[SID103556242]
IC50 77Inhibition of tPMET complex in human HL60 cells after 30 mins by WST-1/mPMS reduction assay [AID729238, Type: Literature]
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48
[SID103556242]
GI50 98Growth inhibition of human FRDA primary patient fibroblasts after 48 hrs by calcein-AM-based cell viability assay [AID642427, Type: Literature]
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49
[SID103556242]
IC50 200Antiproliferative activity against human mitochondrial gene-knockout HL60 cells after 48 hrs by MTT assay [AID729235, Type: Literature]
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50
[SID103556242]
IC50 DRUGMATRIX: Estrogen ERbeta radioligand binding (ligand: [3H] Estradiol) [AID625259, Type: other]Estrogen receptor beta [gi:6166154]
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