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Lidocaine (CID 3676) - Compound BioActivity Data
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BioActivity Outcomes:
Active(34)
 
 
Inactive(1288)
 
 
Inconclusive(50)
 
 
Unspecified(614)
 
 
Top Targets:
7TM GPCR Srx(47)
 
 
 
 
7TM GPCR Srsx(37)
 
 
 
p450(28)
 
 
 
 
Na trans asso..(28)
 
 
 
Tryp SPc(17)
 
 
 
BioAssay Types:
Confirmatory(714)
 
 
 
 
Screening(539)
 
 
 
Literature(460)
 
 
 
 
 
Summary(24)
 
 
 
BioActivity Types:
Potency(502)
 
 
 
 
IC50(196)
 
 
 
 
 
EC50(11)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1568    Data Row: 1986   Total Pages: 100   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103169867]
EC50 0.017Negative inotropic activity against potassium-induced contraction in guinea pig left atrium assessed as decrease in developed tension [AID491141, Type: Literature]
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2
[SID103169867]
EC50 0.017Negative inotropic activity in guinea pig left atria assessed as decrease of 1 Hz current-induced developed tension [AID655940, Type: Literature]
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3
[SID103169867]
EC50 0.017Negative inotropic activity assessed as decrease in developed tension in isolated guinea pig left atrium [AID275639, Type: Literature]
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4
[SID103169867]
IC50 2Modulation of human Nav1.4 in open-inactivated state assessed as inhibition of inward current after 4 mins by whole-cell electrophysiology [AID1069530, Type: Literature]Sodium channel protein type 4 subunit alpha [gi:292495096]
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5
[SID103169867]
IC50 10.5Modulation of human Nav1.3 in open-inactivated state assessed as inhibition of inward current after 4 mins by whole-cell electrophysiology [AID1069531, Type: Literature]Sodium channel protein type 3 subunit alpha [gi:25014054]
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6
[SID103169867]
IC50 29Modulation of human Nav1.7 in open-inactivated state assessed as inhibition of inward current after 4 mins by whole-cell electrophysiology [AID1069527, Type: Literature]Sodium channel protein type 9 subunit alpha [gi:327478559]
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7
[SID103169867]
Sodium channel alpha subunit blocker [AID742738, Type: Literature]Sodium channel protein type 9 subunit alpha [gi:327478559]
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8
[SID103169867]
Sodium channel alpha subunit blocker [AID742738, Type: Literature]Sodium channel protein type 9 subunit alpha [gi:327478559]
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9
[SID103169867]
Sodium channel alpha subunit blocker [AID742738, Type: Literature]Sodium channel protein type 4 subunit alpha [gi:292495096]
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10
[SID103169867]
Sodium channel alpha subunit blocker [AID742738, Type: Literature]Sodium channel protein type 4 subunit alpha [gi:292495096]
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11
[SID103169867]
Sodium channel alpha subunit blocker [AID742738, Type: Literature]Sodium channel protein type 7 subunit alpha [gi:296452902]
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12
[SID103169867]
Sodium channel alpha subunit blocker [AID742738, Type: Literature]Sodium channel protein type 7 subunit alpha [gi:296452902]
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13
[SID103169867]
Sodium channel alpha subunit blocker [AID742738, Type: Literature]Sodium channel protein type 11 subunit alpha [gi:124053649]
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14
[SID103169867]
Sodium channel alpha subunit blocker [AID742738, Type: Literature]Sodium channel protein type 11 subunit alpha [gi:124053649]
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15
[SID103169867]
Sodium channel alpha subunit blocker [AID742738, Type: Literature]Sodium channel protein type 10 subunit alpha [gi:205371821]
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16
[SID103169867]
Sodium channel alpha subunit blocker [AID742738, Type: Literature]Sodium channel protein type 10 subunit alpha [gi:205371821]
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17
[SID103169867]
Sodium channel alpha subunit blocker [AID742738, Type: Literature]Sodium channel protein type 5 subunit alpha [gi:215273881]
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18
[SID103169867]
Sodium channel alpha subunit blocker [AID742738, Type: Literature]Sodium channel protein type 5 subunit alpha [gi:215273881]
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19
[SID103169867]
Sodium channel alpha subunit blocker [AID742738, Type: Literature]Sodium channel protein type 8 subunit alpha [gi:34098756]
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20
[SID103169867]
Sodium channel alpha subunit blocker [AID742738, Type: Literature]Sodium channel protein type 8 subunit alpha [gi:34098756]
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