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BioActivity Data for Compound Ibuprofen (CID 3672)

BioActivity Outcomes:
Active(111)
 
 
Inactive(1628)
 
 
Inconclusive(109)
 
 
Unspecified(2393)
 
 
Top Targets:
7tm 4(88)
 
 
 
prostaglandin..(53)
 
 
 
 
NR LBD PPAR(36)
 
 
 
 
NR LBD ER(29)
 
 
 
 
 
NR LBD AR(24)
 
 
 
 
BioAssay Types:
Confirmatory(930)
 
 
 
 
 
Literature(797)
 
 
 
 
 
Screening(641)
 
 
 
 
Summary(79)
 
 
 
 
BioAssay Categories:
In vitro(174)
 
 
 
 
 
In vivo(1622)
 
 
 
Biochemical(429)
 
 
 
 
Toxicity(1716)
 
 
 
 
ADME(174)
 
 
 
Cell-based(300)
 
 
 
 
 
Organism-base..(16)
 
 
 
BioActivity Types:
Potency(728)
 
 
 
 
 
IC50(284)
 
 
 
 
 
EC50(11)
 
 
Ki(10)
 
 
 
AC50(6)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 3697    Data Row: 4241   Total Pages: 213   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103174500]
IC50 0.1Inhibition activity against recombinant human Prostaglandin G/H synthase 2 [AID162632, Type: Literature]
View
2
[SID103174500]
IC50 0.212DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: confirmatory]Prostaglandin G/H synthase 1 [gi:317373262]
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3
[SID103174500]
IC50 0.22Inhibition of PGE-2 production in 3T3 (murine fibroblast) cell culture. [AID160863, Type: Literature]
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4
[SID103174500]
IC50 0.29Inhibition of COX-1 in human washed platelet assessed as inhibition of 0.5 uM arachidonic acid-induced TXB2 formation incubated for 25 mins prior to arachidonic acid challenge measured after 30 mins by radioimmunoassay [AID747932, Type: Literature]Prostaglandin G/H synthase 1 [gi:317373262]
View
5
[SID103174500]
IC50 0.86Inhibition of COX-2 in mouse RAW264.7 cells assessed as decrease in LPS-induced PGE2 production treated prior to LPS challenge by enzyme immunoassay [AID1125683, Type: Literature]Prostaglandin G/H synthase 2 [gi:548483]
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6
[SID103174500]
IC50 1.06Reversible competitive inhibition of prostaglandin G/H synthase 1 [AID162150, Type: Literature]Prostaglandin G/H synthase 1 [gi:754286265]
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7
[SID103174500]
IC50 1.1Inhibition of bovine COX2 by enzyme immunoassay [AID393820, Type: Literature]Prostaglandin G/H synthase 2 [gi:3914301]
View
8
[SID103174500]
IC50 1.1Inhibition of ovine COX2 by enzyme immuno assay [AID288822, Type: Literature]Prostaglandin G/H synthase 2 [gi:3914304]
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9
[SID103174500]
IC50 1.1Inhibition of ovine COX2 by enzyme immuno assay [AID344874, Type: Literature]Prostaglandin G/H synthase 2 [gi:3914304]
View
10
[SID103174500]
IC50 1.1Inhibition of ovine COX2 by enzyme immunoassay [AID352496, Type: Literature]Prostaglandin G/H synthase 2 [gi:3914304]
View
11
[SID103174500]
IC50 1.1Inhibition of ovine COX2 by enzyme immuno assay [AID368229, Type: Literature]Prostaglandin G/H synthase 2 [gi:3914304]
View
12
[SID103174500]
IC50 1.1In vitro inhibitory concentration against COX-2 enzyme [AID240796, Type: Literature]Prostaglandin G/H synthase 2 [gi:3914304]
View
13
[SID103174500]
IC50 1.1Inhibition of ovine COX2 by enzyme immuno assay [AID461113, Type: Literature]Prostaglandin G/H synthase 2 [gi:3914304]
View
14
[SID103174500]
IC50 1.1Inhibition of ovine COX2 by enzyme immuno assay [AID622556, Type: Literature]Prostaglandin G/H synthase 2 [gi:3914304]
View
15
[SID103174500]
IC50 1.1Inhibition of human recombinant COX2 by enzyme immuno assay [AID603429, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
View
16
[SID103174500]
IC50 1.1Inhibition of human COX2 by enzyme immunoassay [AID494635, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
View
17
[SID103174500]
IC50 1.1Inhibition of human recombinant COX2 by enzyme immuno assay [AID474248, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
View
18
[SID103174500]
IC50 1.1Inhibition of human recombinant COX2 by enzyme immunoassay [AID457929, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
View
19
[SID103174500]
IC50 1.1Inhibition of human recombinant COX2 [AID648862, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
View
20
[SID103174500]
IC50 1.1Inhibition of human recombinant COX2 [AID724444, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
View