Ibuprofen (CID 3672) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(100)
 
 
Inactive(1200)
 
 
Inconclusive(66)
 
 
Unspecified(2148)
 
 
Top Targets:
prostaglandin..(60)
 
 
 
7TM GPCR Srx(48)
 
 
 
7TM GPCR Srsx(30)
 
 
 
GT1 Gtf like(19)
 
 
p450(18)
 
 
 
BioAssay Types:
Literature(668)
 
 
 
 
 
Screening(555)
 
 
 
 
Confirmatory(528)
 
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(400)
 
 
 
 
 
IC50(383)
 
 
 
 
 
EC50(11)
 
 
Ki(11)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 3141    Data Row: 3514   Total Pages: 71   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103459872]
Ki 0.0113Binding affinity to amyloid beta fibrils [AID618052, Type: Literature]
View
2
[SID103459872]
IC50 0.05Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay [AID426392, Type: Literature]Interleukin-8 [gi:124359]
View
3
[SID103459872]
IC50 0.05Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay [AID426392, Type: Literature]Interleukin-8 [gi:124359]
View
4
[SID103459872]
IC50 0.05Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay [AID426392, Type: Literature]Interleukin-8 [gi:124359]
View
5
[SID103174500]
IC50 0.1Inhibition activity against recombinant human Prostaglandin G/H synthase 2 [AID162632, Type: Literature]
View
6
[SID103459872]
IC50 0.11Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear cells [AID248424, Type: Literature]C-X-C chemokine receptor type 2 [gi:1352454]
View
7
[SID103174500]
IC50 0.212DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: other]Prostaglandin G/H synthase 1 [gi:317373262]
View
8
[SID103174500]
IC50 0.22Inhibition of PGE-2 production in 3T3 (murine fibroblast) cell culture. [AID160863, Type: Literature]
View
9
[SID103174500]
IC50 1.06Reverisible competitive inhibition of prostaglandin G/H synthase 1 [AID162150, Type: Literature]
View
10
[SID103174500]
IC50 1.1Inhibition of human COX2 by enzyme immunoassay [AID494635, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
View
11
[SID103174500]
IC50 1.1Inhibition of human recombinant COX2 by enzyme immuno assay [AID603429, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
View
12
[SID103174500]
IC50 1.1Inhibition of human recombinant COX2 [AID648862, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
View
13
[SID103174500]
IC50 1.1Inhibition of human recombinant COX2 by enzyme immunoassay [AID457929, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
View
14
[SID103174500]
IC50 1.1Inhibition of human recombinant COX2 by enzyme immuno assay [AID474248, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
View
15
[SID103174500]
IC50 1.1Inhibition of human recombinant COX2 by enzyme immunoassay [AID447529, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
View
16
[SID103174500]
IC50 1.1Inhibition of human recombinant COX-2 by enzyme immuno assay [AID443725, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
View
17
[SID103174500]
IC50 1.1Inhibition of bovine COX2 by enzyme immunoassay [AID393820, Type: Literature]Prostaglandin G/H synthase 2 [gi:3914301]
View
18
[SID103174500]
IC50 1.1Inhibition of ovine COX2 by enzyme immuno assay [AID368229, Type: Literature]Prostaglandin G/H synthase 2 [gi:3914304]
View
19
[SID103174500]
IC50 1.1Inhibition of ovine COX2 by enzyme immuno assay [AID288822, Type: Literature]Prostaglandin G/H synthase 2 [gi:3914304]
View
20
[SID103174500]
IC50 1.1Inhibition of ovine COX2 by enzyme immuno assay [AID344874, Type: Literature]Prostaglandin G/H synthase 2 [gi:3914304]
View
21
[SID103174500]
IC50 1.1Inhibition of ovine COX2 by enzyme immunoassay [AID352496, Type: Literature]Prostaglandin G/H synthase 2 [gi:3914304]
View
22
[SID103174500]
IC50 1.1In vitro inhibitory concentration against COX-2 enzyme [AID240796, Type: Literature]Prostaglandin G/H synthase 2 [gi:3914304]
View
23
[SID103174500]
IC50 1.1Inhibition of ovine COX2 by enzyme immuno assay [AID622556, Type: Literature]Prostaglandin G/H synthase 2 [gi:3914304]
View
24
[SID103174500]
IC50 1.1Inhibition of ovine COX2 by enzyme immuno assay [AID461113, Type: Literature]Prostaglandin G/H synthase 2 [gi:3914304]
View
25
[SID103174500]
Ki 1.12202Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr [AID360149, Type: Literature]Solute carrier family 22 member 20 [gi:56404586]
View
26
[SID103174500]
IC50 1.35Inhibition of human COX2 expressed in baculovirus system [AID664057, Type: Literature]
View
27
[SID103174500]
IC50 1.4Inhibition of human recombinant COX-2 [AID587449, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
View
28
[SID103174500]
IC50 2Inhibition of Prostaglandin G/H synthase in intact RBL-1 cell line [AID161005, Type: Literature]
View
29
[SID103174500]
IC50 2.9Inhibition of bovine COX-1 by enzyme immuno assay [AID443726, Type: Literature]Prostaglandin G/H synthase 1 [gi:166897622]
View
30
[SID103174500]
IC50 2.9Inhibition of ovine COX1 [AID648861, Type: Literature]Prostaglandin G/H synthase 1 [gi:548481]
View
31
[SID103174500]
IC50 2.9Inhibition of ovine COX1 by enzyme immuno assay [AID603428, Type: Literature]Prostaglandin G/H synthase 1 [gi:548481]
View
32
[SID103174500]
IC50 2.9Inhibition of ovine COX1 by enzyme immuno assay [AID622474, Type: Literature]Prostaglandin G/H synthase 1 [gi:548481]
View
33
[SID103174500]
IC50 2.9Inhibition of bovine COX1 by enzyme immunoassay [AID393818, Type: Literature]Prostaglandin G/H synthase 1 [gi:166897622]
View
34
[SID103174500]
IC50 2.9Inhibition of ovine COX1 by enzyme immuno assay [AID461111, Type: Literature]Prostaglandin G/H synthase 1 [gi:548481]
View
35
[SID103174500]
IC50 2.9Inhibition of ovine COX1 by enzyme immunoassay [AID457928, Type: Literature]Prostaglandin G/H synthase 1 [gi:548481]
View
36
[SID103174500]
IC50 2.9Inhibition of ovine COX1 by enzyme immuno assay [AID474247, Type: Literature]Prostaglandin G/H synthase 1 [gi:548481]
View
37
[SID103174500]
IC50 2.9In vitro inhibitory concentration against COX-1 enzyme [AID240795, Type: Literature]Prostaglandin G/H synthase 1 [gi:548481]
View
38
[SID103174500]
IC50 2.9Inhibition of ovine COX1 by enzyme immunoassay [AID447528, Type: Literature]Prostaglandin G/H synthase 1 [gi:548481]
View
39
[SID103174500]
IC50 2.9Inhibition of ovine COX1 by enzyme immuno assay [AID288821, Type: Literature]Prostaglandin G/H synthase 1 [gi:548481]
View
40
[SID103174500]
IC50 2.9Inhibition of ovine COX1 by enzyme immunoassay [AID352495, Type: Literature]Prostaglandin G/H synthase 1 [gi:548481]
View
41
[SID103174500]
IC50 2.9Inhibition of ovine COX1 by enzyme immuno assay [AID344873, Type: Literature]Prostaglandin G/H synthase 1 [gi:548481]
View
42
[SID103174500]
IC50 2.9Inhibition of ovine COX1 by enzyme immuno assay [AID368225, Type: Literature]Prostaglandin G/H synthase 1 [gi:548481]
View
43
[SID103174500]
IC50 2.9Inhibition of sheep COX1 by enzyme immunoassay [AID494634, Type: Literature]Prostaglandin G/H synthase 1 [gi:548481]
View
44
[SID103174500]
IC50 3Binding affinity to bovine serum albumin [AID323982, Type: Literature]Serum albumin [gi:1351907]
View
45
[SID103174500]
IC50 3Binding affinity to bovine serum albumin [AID323982, Type: Literature]Serum albumin [gi:1351907]
View
46
[SID103174500]
IC50 3Inhibition of Prostaglandin G/H synthase 1 (COX-1). [AID161680, Type: Literature]Prostaglandin G/H synthase 1 [gi:317373262]
View
47
[SID103174500]
IC50 3Inhibitory activity against prostaglandin G/H synthase 1 (COX-1) [AID161655, Type: Literature]
View
48
[SID103174500]
IC50 3Concentration (in uM) to inhibit 50% of Prostaglandin G/H synthase 1 (COX-1) and is expressed in IC50. [AID161679, Type: Literature]
View
49
[SID103174500]
IC50 4Inhibition of ovine COX-1 [AID587448, Type: Literature]Prostaglandin G/H synthase 1 [gi:548481]
View
50
[SID103174500]
Ki 4.67735Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hr [AID360150, Type: Literature]Solute carrier family 22 member 6 [gi:81901833]
View